{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T09:08:13Z","timestamp":1789117693880,"version":"build-2803163510"},"reference-count":15,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T00:00:00Z","timestamp":1789084800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Life"],"abstract":"<jats:p>Background: Renal cell carcinoma (RCC) arising in a kidney allograft is a rare but challenging condition, requiring a careful balance between oncologic control and preservation of graft function. Minimally invasive nephron-sparing approaches may represent a valuable treatment option in selected recipients. Case Presentation: We report the case of a 59-year-old kidney transplant recipient diagnosed with papillary RCC in the renal allograft during routine imaging follow-up. The patient underwent CT-guided percutaneous cryoablation, combined with conversion of immunosuppressive therapy to an mTOR inhibitor-based regimen. The procedure was completed successfully without complications, and graft function was preserved. At 3-year follow-up, no evidence of local recurrence or distant metastasis was detected, with stable renal function maintained throughout the observation period. Conclusions: This case highlights the feasibility and effectiveness of percutaneous cryoablation as a nephron-sparing treatment for RCC arising in a renal allograft. In carefully selected high-risk transplant recipients, this approach may provide durable oncologic control while preserving graft function.<\/jats:p>","DOI":"10.3390\/life16091513","type":"journal-article","created":{"date-parts":[[2026,9,11]],"date-time":"2026-09-11T08:17:42Z","timestamp":1789114662000},"page":"1513","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Papillary Renal Cell Carcinoma in a Functioning Kidney Allograft: A Graft-Preserving Strategy with Cryoablation and mTORi Conversion"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0009-0004-9744-1482","authenticated-orcid":false,"given":"Nicola","family":"Schiavone","sequence":"first","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2648-6021","authenticated-orcid":false,"given":"Dario","family":"Troise","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"},{"name":"Division of Renal Medicine and Baxter Novum, Department of Clinical Science, Intervention and Technology, Karolinska Instituted, 141 52 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7425-1166","authenticated-orcid":false,"given":"Marco","family":"Finati","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5547-8747","authenticated-orcid":false,"given":"Anna","family":"Ricapito","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Oscar","family":"Selvaggio","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Mercuri","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Martina Pia","family":"Miracapillo","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Luciana Antonia","family":"Cirolla","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ugo Giovanni","family":"Falagario","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"},{"name":"Urology Unit, Department of Molecular Medicine and Surgery, Solna, Karolinska Institutet, 141 52 Stockholm, Sweden"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Francesca","family":"Sanguedolce","sequence":"additional","affiliation":[{"name":"Department of Pathology, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Barbara","family":"Infante","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giuseppe","family":"Carrieri","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giovanni","family":"Stallone","sequence":"additional","affiliation":[{"name":"Nephrology, Dialysis and Transplantation Unit, Advanced Research Center on Kidney Aging (A.R.K.A.), Department of Medical and Surgical Sciences, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gaetano Valerio","family":"Palella","sequence":"additional","affiliation":[{"name":"Department of Urology and Renal Transplantation, University of Foggia, 71122 Foggia, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2026,9,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Trushkin, R.N., Isaev, T.K., Medvedev, P.E., Shcheglov, N.E., Variasin, V.V., Lysenko, M.A., Dmitriev, I.V., Balkarov, A.G., and Kesaeva, L.A. 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