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This process is transcriptionally regulated by key factors including PPAR\u03b3 and C\/EBP\u03b2, alongside FABP4 during lipogenesis. However, it is now well established that a significant portion of this regulation is also mediated by small non-coding RNAs (miRNAs) and long non-coding RNAs (lncRNAs), which post-transcriptionally modulate gene expression. This study aimed to identify key miRNAs involved in adipogenesis and to determine how Aloe-emodin, a molecule with potent anti-inflammatory properties known to modulate adipocyte differentiation, alters their expression. Using an integrative approach combining 3T3-L1 cell culture, RNA-seq, and qPCR analyses, this study demonstrates that Aloe-emodin can upregulate transcription factors (PPAR\u03b3 and C\/EBP\u03b2) as well as miR-143 and miR-155, suggesting its potential as a modulator of adipogenic gene or miRNA expression in this exploratory setting.<\/jats:p>","DOI":"10.3390\/life16091552","type":"journal-article","created":{"date-parts":[[2026,9,16]],"date-time":"2026-09-16T13:50:27Z","timestamp":1789566627000},"page":"1552","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":0,"title":["Aloe-Emodin Modifies Adipogenic Genes and the Expression of miR-143 and miR-155 in 3T3-L1 Cells"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4525-7734","authenticated-orcid":false,"given":"Carlos Uriel","family":"Torres-Estrella","sequence":"first","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Gen\u00e9tica de Enfermedades Metab\u00f3licas, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7009-0465","authenticated-orcid":false,"given":"Jose Luis","family":"Acosta-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Centro Interdisciplinario de Investigaci\u00f3n para el Desarrollo Integral Regional, Boulevard Juan de Dios B\u00e1tiz Paredes, Guasave 81049, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4627-5213","authenticated-orcid":false,"given":"Julio Jes\u00fas","family":"Garcia-Coste","sequence":"additional","affiliation":[{"name":"Laboratorio de Investigaci\u00f3n en Gen\u00e9tica de Enfermedades Metab\u00f3licas, Escuela Superior de Medicina, Instituto Polit\u00e9cnico Nacional, Mexico City 11340, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"},{"role":"formal-analysis","vocabulary":"credit"},{"role":"data-curation","vocabulary":"credit"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6556-1632","authenticated-orcid":false,"given":"Fausto","family":"S\u00e1nchez-Mu\u00f1oz","sequence":"additional","affiliation":[{"name":"Departamento de Fisiolog\u00eda, Instituto Nacional de Cardiolog\u00eda, Juan Badiano No. 1, Col. 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