{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,25]],"date-time":"2026-09-25T02:46:47Z","timestamp":1790304407082,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T00:00:00Z","timestamp":1496793600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["MAT2013-48426-C2-2-R"],"award-info":[{"award-number":["MAT2013-48426-C2-2-R"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Detailed information about graft material characteristic is crucial to evaluate their clinical outcomes. The present study evaluates the physico-chemical characteristics of two xenografts manufactured on an industrial scale deproteinized at different temperatures (non-sintered and sintered) in accordance with a protocol previously used in sinus lift procedures. It compares how the physico-chemical properties influence the material\u2019s performance in vivo by a histomorphometric study in retrieved bone biopsies following maxillary sinus augmentation in 10 clinical cases. An X-ray diffraction analysis revealed the typical structure of hydroxyapatite (HA) for both materials. Both xenografts were porous and exhibited intraparticle pores. Strong differences were observed in terms of porosity, crystallinity, and calcium\/phosphate. Histomorphometric measurements on the bone biopsies showed statistically significant differences. The physic-chemical assessment of both xenografts, made in accordance with the protocol developed on an industrial scale, confirmed that these products present excellent biocompatibilitity, with similar characteristics to natural bone. The sintered HA xenografts exhibited greater osteoconductivity, but were not completely resorbable (30.80 \u00b1 0.88% residual material). The non-sintered HA xenografts induced about 25.92 \u00b1 1.61% of new bone and a high level of degradation after six months of implantation. Differences in the physico-chemical characteristics found between the two HA xenografts determined a different behavior for this material.<\/jats:p>","DOI":"10.3390\/ma10060623","type":"journal-article","created":{"date-parts":[[2017,6,7]],"date-time":"2017-06-07T10:01:20Z","timestamp":1496829680000},"page":"623","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Comparison of Two Xenograft Materials Used in Sinus Lift Procedures: Material Characterization and In Vivo Behavior"],"prefix":"10.3390","volume":"10","author":[{"given":"Mar\u00eda","family":"Ram\u00edrez Fern\u00e1ndez","sequence":"first","affiliation":[{"name":"C\u00e1tedra Internacional de Investigaci\u00f3n en Odontolog\u00eda, Universidad Cat\u00f3lica San Antonio de Murcia, Avda. Jer\u00f3nimos, 135, 30107 Guadalupe, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7704-7577","authenticated-orcid":false,"given":"Patricia","family":"Maz\u00f3n","sequence":"additional","affiliation":[{"name":"Departamento de Materiales, \u00d3ptica y Tecnologia Electr\u00f3nica, Universidad Miguel Hern\u00e1ndez, Avda. Universidad s\/n, 03202-Elche, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5863-9101","authenticated-orcid":false,"given":"Sergio","family":"Gehrke","sequence":"additional","affiliation":[{"name":"Biotecnos Research Center, Rua Dr. Bonazo n\u00b0 57, 97015-001-Santa Maria (RS), Brazil"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4067-2253","authenticated-orcid":false,"given":"Jose","family":"Calvo-Guirado","sequence":"additional","affiliation":[{"name":"C\u00e1tedra Internacional de Investigaci\u00f3n en Odontolog\u00eda, Universidad Cat\u00f3lica San Antonio de Murcia, Avda. Jer\u00f3nimos, 135, 30107 Guadalupe, Murcia, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9316-4407","authenticated-orcid":false,"given":"Piedad","family":"De Aza","sequence":"additional","affiliation":[{"name":"Instituto de Bioingenieria, Universidad Miguel Hernandez, Avda. Ferrocarril s\/n. 03202-Elche, Alicante, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2017,6,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"78","DOI":"10.1016\/j.jdent.2014.08.006","article-title":"Long-term survival rate of implants placed in conjunction with 246 sinus floor elevation procedures: Results of a 15-year retrospective study","volume":"43","author":"Beretta","year":"2015","journal-title":"J. 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Oral Implants Res."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/10\/6\/623\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T18:38:17Z","timestamp":1760207897000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/10\/6\/623"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2017,6,7]]},"references-count":52,"journal-issue":{"issue":"6","published-online":{"date-parts":[[2017,6]]}},"alternative-id":["ma10060623"],"URL":"https:\/\/doi.org\/10.3390\/ma10060623","relation":{"has-preprint":[{"id-type":"doi","id":"10.20944\/preprints201703.0226.v1","asserted-by":"object"}]},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2017,6,7]]}}}