{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,9]],"date-time":"2026-01-09T00:50:05Z","timestamp":1767919805275,"version":"3.49.0"},"reference-count":60,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,1,28]],"date-time":"2018-01-28T00:00:00Z","timestamp":1517097600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Serum albumin has been identified as an endogenous protein that is integral to early bone regeneration. We hypothesized that albumin addition to allografts may result in better bone remodeling than what can be achieved with anorganic xenografts. Sinus elevations were performed at 32 sites of 18 patients with the lateral window technique. Sites either received filling with an anorganic bovine bone mineral (ABBM, BioOss, Geistlich, CH) or albumin impregnated allograft (BoneAlbumin, OrthoSera, AT). After 6-months patients received dental implants and 16 bone core biopsy samples were obtained from the ABBM filled, and 16 from the BoneAlbumin augmented sites. The biopsies were examined by histomorphometry and \u00b5CT. Percentage of the residual graft in the BoneAlbumin group was 0\u201312.7%, median 5.4% vs. ABBM 6.3\u201335.9%, median 16.9%, p &lt; 0.05. Results of the \u00b5CT analysis showed that the microarchitecture of the augmented bone in the BoneAlbumin group resembles that of the native maxilla in morphometric parameters Trabecular Pattern Factor and Connectivity. Our data show that while ABBM successfully integrates into the newly formed bone tissue as persisting particles, BoneAlbumin is underway towards complete remodeling with new bone closely resembling that of the intact maxilla.<\/jats:p>","DOI":"10.3390\/ma11020202","type":"journal-article","created":{"date-parts":[[2018,1,29]],"date-time":"2018-01-29T07:46:20Z","timestamp":1517211980000},"page":"202","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Microarchitecture of the Augmented Bone Following Sinus Elevation with an Albumin Impregnated Demineralized Freeze-Dried Bone Allograft (BoneAlbumin) versus Anorganic Bovine Bone Mineral: A Randomized Prospective Clinical, Histomorphometric, and Micro-Computed Tomography Study"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0728-7027","authenticated-orcid":false,"given":"Kivovics","family":"M\u00e1rton","sequence":"first","affiliation":[{"name":"Department of Community Dentistry, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szab\u00f3","family":"Tam\u00e1s","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostics, Semmelweis University, Szentkir\u00e1lyi utca 47, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"N\u00e9meth","family":"Orsolya","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Czink\u00f3czky","family":"B\u00e9la","sequence":"additional","affiliation":[{"name":"Department of Community Dentistry, Semmelweis University, Szentkir\u00e1lyi utca 40, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"D\u0151ri","family":"Ferenc","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, Szentkir\u00e1lyi utca 47, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nagy","family":"P\u00e9ter","sequence":"additional","affiliation":[{"name":"Department of Pathology and Experimental Cancer Research, Semmelweis University, \u00dcll\u0151i \u00fat 26, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Dob\u00f3-Nagy","family":"Csaba","sequence":"additional","affiliation":[{"name":"Department of Oral Diagnostics, Semmelweis University, Szentkir\u00e1lyi utca 47, 1088 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cs\u00f6nge","family":"Lajos","sequence":"additional","affiliation":[{"name":"Petz Alad\u00e1r County Hospital, West Hungarian Regional Tissue Bank, Vasv\u00e1ri P\u00e1l u. 2\u20134, 9024 Gy\u0151r, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Lacza","family":"Zsombor","sequence":"additional","affiliation":[{"name":"Institute of Clinical Experimental Research, Semmelweis University, T\u0171zolt\u00f3 u. 37\u201347, 1094 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Mijiritsky","family":"Eitan","sequence":"additional","affiliation":[{"name":"Department of Oral Rehabilitation, Tel Aviv University, Ramat Aviv, Tel Aviv 6997801, Israel"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Szab\u00f3","family":"Gy\u00f6rgy","sequence":"additional","affiliation":[{"name":"Department of Oro-Maxillofacial Surgery and Stomatology, Semmelweis University, M\u00e1ria utca 52, 1085 Budapest, Hungary"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2018,1,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.dental.2010.10.017","article-title":"Deproteinized bovine bone in periodontal and implant surgery","volume":"27","author":"Baldini","year":"2011","journal-title":"Dent. 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