{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T16:12:39Z","timestamp":1790179959315,"version":"4.1.0"},"reference-count":32,"publisher":"MDPI AG","issue":"2","license":[{"start":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T00:00:00Z","timestamp":1519257600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Particle-induced periprosthetic osteolysis and subsequent aseptic implant loosening are a major cause of compromising the long-term results of total joint replacements. To date, no implant has been able to mirror radically the tribological factors (friction\/lubrication\/wear) of in vivo tribological pairings. Carbon-Fibre Reinforced SiC-Composites (C\/SiSiC), a material primarily developed for brake technology, has the opportunity to fulfil this requirement. Until now, the material itself has not been used in medicine. The aim of this investigation was to test the suitability of C\/SiSiC ceramics as a new material for bearing couples in endoprosthetics. After the preparation of the composites flexural strength was determined as well as the Young\u2019s-modulus and the coefficient of friction. To investigate in vitro biological properties, MG 63 and primary human osteoblasts were cultured on C\/SiSiC composites. To review the proliferation, the cytotoxicity standardized tests were used. The cell morphology was observed by light microscopy, ESEM, confocal and 3D-laserscanning microscopy. C\/SiSiC possesses a high resistance to wear. Cells exhibited no significant alterations in morphology. Vitality was not impaired by contact with the ceramic composite. There was no higher cytotoxicity to observe. Regarding these results, C\/SiSiC ceramics seem to be biologically and mechanically appropriate for orthopaedic applications.<\/jats:p>","DOI":"10.3390\/ma11020316","type":"journal-article","created":{"date-parts":[[2018,2,22]],"date-time":"2018-02-22T07:05:41Z","timestamp":1519283141000},"page":"316","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Carbon-Fibre-Reinforced SiC Composite (C\/SiSiC) as an Alternative Material for Endoprosthesis: Fabrication, Mechanical and In-Vitro Biological Properties"],"prefix":"10.3390","volume":"11","author":[{"given":"Aline","family":"Reichert","sequence":"first","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6643-6358","authenticated-orcid":false,"given":"Michael","family":"Seidenstuecker","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rainer","family":"Gadow","sequence":"additional","affiliation":[{"name":"Institute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart; Allmandring 7b, 70569 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hermann","family":"Mayr","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Norbert","family":"Suedkamp","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8369-077X","authenticated-orcid":false,"given":"Sergio","family":"Latorre","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Partick","family":"Weichand","sequence":"additional","affiliation":[{"name":"Institute for Manufacturing Technologies of Ceramic Components and Composites, University of Stuttgart; Allmandring 7b, 70569 Stuttgart, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Anke","family":"Bernstein","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Trauma Surgery, Medical Center\u2014Albert-Ludwigs-University of Freiburg, Faculty of Medicine, Albert-Ludwigs-University of Freiburg, Hugstetter Stra\u00dfe 55, 79106 Freiburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,2,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2434","DOI":"10.1016\/j.actbio.2012.03.029","article-title":"What\u2019s next? 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