{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,26]],"date-time":"2026-08-26T06:33:01Z","timestamp":1787725981456,"version":"build-2784847793"},"reference-count":56,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T00:00:00Z","timestamp":1529971200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100013704","name":"CONACYT","doi-asserted-by":"publisher","award":["256063"],"award-info":[{"award-number":["256063"]}],"id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100013704","name":"CONACYT","doi-asserted-by":"publisher","award":["271182"],"award-info":[{"award-number":["271182"]}],"id":[{"id":"10.13039\/501100013704","id-type":"DOI","asserted-by":"publisher"}]},{"name":"PRODEP","award":["DSA\/103.5\/15\/11048"],"award-info":[{"award-number":["DSA\/103.5\/15\/11048"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Vaccinology faces the challenge of developing improved immunization approaches that are able to induce long-term immunity with the desired Th profile according to the pathology. In this context, new vehicles for efficient antigen delivery that exert adjuvant effects play a critical role in addressing this goal. Herein, mesoporous silicon particles (PSiP) were assessed as carriers for a peptide-based vaccine targeting the receptor for advanced glycation end products (RAGE), which is a relevant receptor in Alzheimer\u00b4s disease and other diseases. A RAGE peptide was adsorbed onto PSiP (PSiP vaccine) and administered to BALB\/c mice, leading to immune responses that were similar in magnitude to those induced by the soluble peptide. However, the response induced by PSiP lasted for a significantly longer period when compared with the behavior of the group immunized with the peptide alone. Therefore, PSiP are proposed as carriers to enhance immune memory, which is critical in vaccination. This study opens interesting perspectives related to the application of PSiP in vaccinology.<\/jats:p>","DOI":"10.3390\/ma11071083","type":"journal-article","created":{"date-parts":[[2018,6,26]],"date-time":"2018-06-26T10:40:50Z","timestamp":1530009650000},"page":"1083","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Mesoporous Silicon Particles Favor the Induction of Long-Lived Humoral Responses in Mice to a Peptide-Based Vaccine"],"prefix":"10.3390","volume":"11","author":[{"given":"Gabriela","family":"Navarro-Tovar","sequence":"first","affiliation":[{"name":"Laboratorio de Biofarmac\u00e9uticos Recombinantes, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"},{"name":"Secci\u00f3n de Biotecnolog\u00eda, Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas 2\u00aa. Secci\u00f3n, San Luis Potos\u00ed 78210, Mexico"},{"name":"Consejo Nacional de Ciencia y Tecnolog\u00eda, CONACyT, Av. Insurgentes Sur 1582, Col. Cr\u00e9dito Constructor, Del. Benito Juarez, Ciudad de Mexico 03940, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Denisse","family":"Rocha-Garc\u00eda","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Biotecnolog\u00eda, Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas 2\u00aa. Secci\u00f3n, San Luis Potos\u00ed 78210, Mexico"},{"name":"Laboratorio de Biopol\u00edmeros y Nanoestructuras, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potosi, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alejandra","family":"Wong-Arce","sequence":"additional","affiliation":[{"name":"Laboratorio de Biofarmac\u00e9uticos Recombinantes, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"},{"name":"Secci\u00f3n de Biotecnolog\u00eda, Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas 2\u00aa. Secci\u00f3n, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gabriela","family":"Palestino","sequence":"additional","affiliation":[{"name":"Secci\u00f3n de Biotecnolog\u00eda, Centro de Investigaci\u00f3n en Ciencias de la Salud y Biomedicina, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Sierra Leona 550, Lomas 2\u00aa. Secci\u00f3n, San Luis Potos\u00ed 78210, Mexico"},{"name":"Laboratorio de Biopol\u00edmeros y Nanoestructuras, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potosi, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sergio","family":"Rosales-Mendoza","sequence":"additional","affiliation":[{"name":"Laboratorio de Biofarmac\u00e9uticos Recombinantes, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potos\u00ed, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"},{"name":"Laboratorio de Biopol\u00edmeros y Nanoestructuras, Facultad de Ciencias Qu\u00edmicas, Universidad Aut\u00f3noma de San Luis Potosi, Av. Dr. Manuel Nava 6, San Luis Potos\u00ed 78210, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,6,26]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1597","DOI":"10.1038\/nm.3409","article-title":"Key Roles of Adjuvants in Modern Vaccines","volume":"19","author":"Reed","year":"2013","journal-title":"Nat. Med."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.bcp.2016.05.001","article-title":"Vaccine Technologies: From Whole Organisms to Rationally Designed Protein Assemblies","volume":"120","author":"Karch","year":"2016","journal-title":"Biochem. 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