{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T23:49:05Z","timestamp":1790984945939,"version":"4.1.0"},"reference-count":31,"publisher":"MDPI AG","issue":"10","license":[{"start":{"date-parts":[[2018,9,27]],"date-time":"2018-09-27T00:00:00Z","timestamp":1538006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001665","name":"Agence Nationale de la Recherche","doi-asserted-by":"publisher","award":["ANR-10-LABX-33"],"award-info":[{"award-number":["ANR-10-LABX-33"]}],"id":[{"id":"10.13039\/501100001665","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Among cardiovascular diseases, atherosclerosis remains the first cause of death in the United States of America and Europe, as it leads to myocardial infarction or stroke. The high prevalence of heart diseases is due to the difficulty in diagnosing atherosclerosis, since it can develop for decades before symptoms occur, and to the complexity of the treatment since targets are also important components of the host defenses. The antidiabetics thiazolidinediones, among which is rosiglitazone (RSG), have demonstrated anti-atherosclerotic effect in animal models, and are therefore promising candidates for the improvement of atherosclerosis management. Nevertheless, their administration is hindered by the insurgence of severe side effects. To overcome this limitation, rosiglitazone has been encapsulated into polymeric nanoparticles, which permit efficient delivery to its nuclear target, and selective delivery to the site of action, allowing the reduction of unwanted effects. In the present work, we describe nanoparticle formulation using polylactic acid (PLA) coupled to polyethylene glycol (PEG), their characterization, and their behavior on RAW264.7 macrophages, an important target in atherosclerosis treatment. RSG nanocarriers showed no toxicity on cells at all concentrations tested, an anti-inflammatory effect in a dose-dependent manner, up to 5 times more efficient than the free molecule, and an increased RSG uptake which is consistent with the effect shown. These biodegradable nanoparticles represent a valid tool to be further investigated for the treatment of atherosclerosis.<\/jats:p>","DOI":"10.3390\/ma11101845","type":"journal-article","created":{"date-parts":[[2018,9,28]],"date-time":"2018-09-28T02:54:54Z","timestamp":1538103294000},"page":"1845","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["PLA-PEG Nanoparticles Improve the Anti-Inflammatory Effect of Rosiglitazone on Macrophages by Enhancing Drug Uptake Compared to Free Rosiglitazone"],"prefix":"10.3390","volume":"11","author":[{"given":"Giovanna","family":"Giacalone","sequence":"first","affiliation":[{"name":"Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, 92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2095-2626","authenticated-orcid":false,"given":"Nicolas","family":"Tsapis","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, 92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ludivine","family":"Mousnier","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, 92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"H\u00e9l\u00e8ne","family":"Chacun","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, 92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3194-961X","authenticated-orcid":false,"given":"Elias","family":"Fattal","sequence":"additional","affiliation":[{"name":"Institut Galien Paris-Sud, CNRS, Univ. Paris-Sud, Universit\u00e9 Paris-Saclay, 92296 Ch\u00e2tenay-Malabry, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1755","DOI":"10.1136\/heartjnl-2014-307099","article-title":"The vulnerable atherosclerotic plaque: In vivo identification and potential therapeutic avenues","volume":"101","author":"Adamson","year":"2015","journal-title":"Heart"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"2H","DOI":"10.1016\/j.amjcard.2006.03.002","article-title":"From vulnerable plaque to vulnerable patient\u2014Part iii: Executive summary of the screening for heart attack prevention and education (shape) task force report","volume":"98","author":"Naghavi","year":"2006","journal-title":"Am. J. 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