{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,31]],"date-time":"2026-08-31T18:23:59Z","timestamp":1788200639760,"version":"build-2803163510"},"reference-count":35,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2018,12,13]],"date-time":"2018-12-13T00:00:00Z","timestamp":1544659200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100007709","name":"Fondo de Cooperaci\u00f3n Internacional en Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["278278"],"award-info":[{"award-number":["278278"]}],"id":[{"id":"10.13039\/501100007709","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003141","name":"Consejo Nacional de Ciencia y Tecnolog\u00eda","doi-asserted-by":"publisher","award":["242634"],"award-info":[{"award-number":["242634"]}],"id":[{"id":"10.13039\/501100003141","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100000308","name":"British Council","doi-asserted-by":"publisher","award":["278278"],"award-info":[{"award-number":["278278"]}],"id":[{"id":"10.13039\/501100000308","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>In this work, we assess the effects of sterilization in materials manufactured using additive manufacturing by employing a sterilization technique used in the food industry. To estimate the feasibility of the hydrostatic high-pressure (HHP) sterilization of biomedical devices, we have evaluated the mechanical properties of specimens produced by commercial 3D printers. Evaluations of the potential advantages and drawbacks of Fused Deposition Modeling (FDM), Digital Light Processing (DLP) technology, and Stereolithography (SLA) were considered for this study due to their widespread availability. Changes in mechanical properties due to the proposed sterilization technique were compared to values derived from the standardized autoclaving methodology. Enhancement of the mechanical properties of samples treated with Hydrostatic high-pressure processing enhanced mechanical properties, with a 30.30% increase in the tensile modulus and a 26.36% increase in the ultimate tensile strength. While traditional autoclaving was shown to systematically reduce the mechanical properties of the materials employed and damages and deformation on the surfaces were observed, HHP offered an alternative for sterilization without employing heat. These results suggest that while forgoing high-temperature for sanitization, HHP processing can be employed to take advantage of the flexibility of additive manufacturing technologies for manufacturing implants, instruments, and other devices.<\/jats:p>","DOI":"10.3390\/ma11122540","type":"journal-article","created":{"date-parts":[[2018,12,14]],"date-time":"2018-12-14T03:58:17Z","timestamp":1544759897000},"page":"2540","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":29,"title":["Hydrostatic High-Pressure Post-Processing of Specimens Fabricated by DLP, SLA, and FDM: An Alternative for the Sterilization of Polymer-Based Biomedical Devices"],"prefix":"10.3390","volume":"11","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9463-6688","authenticated-orcid":false,"given":"Jos\u00e9 A. Robles","family":"Linares-Alvelais","sequence":"first","affiliation":[{"name":"Department of Mechanical Engineering and Advanced Materials, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico"},{"name":"Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca 66629, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"J. Obedt","family":"Figueroa-Cavazos","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Advanced Materials, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"C.","family":"Chuck-Hernandez","sequence":"additional","affiliation":[{"name":"Centro de Biotecnolog\u00eda FEMSA, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0782-1974","authenticated-orcid":false,"given":"Hector R.","family":"Siller","sequence":"additional","affiliation":[{"name":"Department of Engineering Technology, University of North Texas, 3940 N. Elm. St., Denton, TX 76207, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2289-4239","authenticated-orcid":false,"given":"Ciro A.","family":"Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Advanced Materials, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico"},{"name":"Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca 66629, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7475-8138","authenticated-orcid":false,"given":"J. Israel","family":"Mart\u00ednez-L\u00f3pez","sequence":"additional","affiliation":[{"name":"Department of Mechanical Engineering and Advanced Materials, Tecnologico de Monterrey, Monterrey 64849, NL, Mexico"},{"name":"Laboratorio Nacional de Manufactura Aditiva y Digital (MADiT), Apodaca 66629, NL, Mexico"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2018,12,13]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1007\/s10529-015-1975-1","article-title":"Three-dimensional bioprinting in tissue engineering and regenerative medicine","volume":"38","author":"Gao","year":"2016","journal-title":"Biotechnol. Lett."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Bose, S., Ke, D., Sahasrabudhe, H., and Bandyopadhyay, A. (2017). Additive Manufacturing of Biomaterials. Prog. Mater. 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