{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,1]],"date-time":"2026-10-01T04:02:29Z","timestamp":1790827349863,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T00:00:00Z","timestamp":1561939200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100002347","name":"Bundesministerium f\u00fcr Bildung und Forschung","doi-asserted-by":"publisher","award":["13EZ1208A\/B"],"award-info":[{"award-number":["13EZ1208A\/B"]}],"id":[{"id":"10.13039\/501100002347","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001659","name":"Deutsche Forschungsgemeinschaft","doi-asserted-by":"publisher","award":["INST 105022\/58-1 FUGG"],"award-info":[{"award-number":["INST 105022\/58-1 FUGG"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Magnesium phosphate cements (MPC) have been demonstrated to have a superior bone regeneration capacity due to their good solubility under in vivo conditions. While in the past only aqueous MPC pastes have been applied, the current study describes the fabrication and in vitro\/in vivo testing of an oil-based calcium doped magnesium phosphate (CaMgP) cement paste. Premixed oil-based pastes with CaMgP chemistry combine the advantages of conventional MPC such as high mechanical strength and good resorbability with a prolonged shelf-life and an easier clinical handling. The pastes set in an aqueous environment and predominantly form struvite and achieve a compressive strength of ~8\u201310 MPa after setting. The implantation into a drill-hole defect at the distal femoral condyle of New Zealand white rabbits over a course of 6 and 12 weeks demonstrated good biocompatibility of the materials without the formation of soft connective tissue or any signs of inflammation. In contrast to a hydroxyapatite forming reference paste, the premixed CaMgP pastes showed subsequent degradation and bony regeneration. The CaMgP cement pastes presented herein are promising bone replacement materials with excellent material properties for an improved and facilitated clinical application.<\/jats:p>","DOI":"10.3390\/ma12132119","type":"journal-article","created":{"date-parts":[[2019,7,1]],"date-time":"2019-07-01T10:54:47Z","timestamp":1561978487000},"page":"2119","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":44,"title":["Development and Bone Regeneration Capacity of Premixed Magnesium Phosphate Cement Pastes"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-8459-4392","authenticated-orcid":false,"given":"Andrea","family":"Ewald","sequence":"first","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Dorothea","family":"Kreczy","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Theresa","family":"Br\u00fcckner","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Gbureck","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melanie","family":"Bengel","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Hoess","sequence":"additional","affiliation":[{"name":"INNOTERE GmbH, Meissner Strasse 191, 01445 Radebeul, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Berthold","family":"Nies","sequence":"additional","affiliation":[{"name":"INNOTERE GmbH, Meissner Strasse 191, 01445 Radebeul, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Julia","family":"Bator","sequence":"additional","affiliation":[{"name":"Department for Functional Materials in Medicine and Dentistry, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Uwe","family":"Klammert","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Andreas","family":"Fuchs","sequence":"additional","affiliation":[{"name":"Department of Oral &amp; Maxillofacial Plastic Surgery, University Hospital W\u00fcrzburg, Pleicherwall 2, 97070 W\u00fcrzburg, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2019,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"429","DOI":"10.1007\/s10856-010-4220-4","article-title":"Formation and properties of magnesium-ammonium-phosphate hexahydrate biocements in the Ca-Mg-PO4 system","volume":"22","author":"Vorndran","year":"2011","journal-title":"J. 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