{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,27]],"date-time":"2026-10-27T10:05:15Z","timestamp":1793095515515,"version":"4.5.0"},"reference-count":27,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2019,10,24]],"date-time":"2019-10-24T00:00:00Z","timestamp":1571875200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Women in Science and Engineering, Eindhoven University of Technology","award":["WISE-2014-1004081"],"award-info":[{"award-number":["WISE-2014-1004081"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Bioactive glass (BAG) granules (S53P4) have shown good clinical results in one-stage treatment of osteomyelitis. During this treatment, a cortical window is created, and infected bone is debrided, which results in large defects that affect the mechanical properties of the bone. This study aimed to evaluate the role of BAG granules in load-bearing bone defect grafting. First, the influence of the geometry of the cortical window on the bone bending stiffness and estimated failure moments was evaluated using micro finite element analysis (\u00b5FE). This resulted in significant differences between the variations in width and length. In addition, \u00b5FE analysis showed that BAG granules contribute to bearing loads in simulated compression of a tibia with a defect grafted with BAG and a BAG and bone morsel mixture. These mixtures potentially can unload the cortical bone that is weakened by a large defect directly after the operation by up to approximately 25%, but only in case of optimal load transfer through the mixture.<\/jats:p>","DOI":"10.3390\/ma12213481","type":"journal-article","created":{"date-parts":[[2019,10,25]],"date-time":"2019-10-25T04:41:27Z","timestamp":1571978487000},"page":"3481","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Implantation of Bioactive Glass Granules Can Contribute the Load-Bearing Capacity of Bones Weakened by Large Cortical Defects"],"prefix":"10.3390","volume":"12","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0162-490X","authenticated-orcid":false,"given":"Nicole A. P.","family":"van Gestel","sequence":"first","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"},{"name":"Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Floor","family":"Gabriels","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0973-572X","authenticated-orcid":false,"given":"Jan A. P.","family":"Geurts","sequence":"additional","affiliation":[{"name":"Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, PO Box 5800, 6229 HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0850-1999","authenticated-orcid":false,"given":"Dennis J. W.","family":"Hulsen","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"},{"name":"Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, PO Box 5800, 6229 HX Maastricht, The Netherlands"},{"name":"MICT Department, Jeroen Bosch Ziekenhuis, P.O. Box 90153, 5200 ME \u2019s-Hertogenbosch, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7662-3990","authenticated-orcid":false,"given":"Caroline E.","family":"Wyers","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands"},{"name":"Department of Internal Medicine, NUTRIM School for Translational Research in Metabolism, Maastricht UMC+, PO Box 5800, 6229 HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Joop P.","family":"van de Bergh","sequence":"additional","affiliation":[{"name":"Department of Internal Medicine, VieCuri Medical Center, Tegelseweg 210, 5912 BL Venlo, The Netherlands"},{"name":"Department of Internal Medicine, NUTRIM School for Translational Research in Metabolism, Maastricht UMC+, PO Box 5800, 6229 HX Maastricht, The Netherlands"},{"name":"Biomedical Research Institute, Hasselt University, Agoralaan Building D, 3590 Diepenbeek, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7372-4072","authenticated-orcid":false,"given":"Keita","family":"Ito","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"},{"name":"Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sandra","family":"Hofmann","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"},{"name":"Institute for Complex Molecular Systems, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jacobus J.","family":"Arts","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. Box 513, 5600 MB Eindhoven, The Netherlands"},{"name":"Department of Orthopaedic Surgery, Research School CAPHRI, Maastricht University Medical Centre, PO Box 5800, 6229 HX Maastricht, The Netherlands"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bert","family":"van Rietbergen","sequence":"additional","affiliation":[{"name":"Orthopaedic Biomechanics, Department of Biomedical Engineering, Eindhoven University of Technology, P.O. 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Med."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"S53","DOI":"10.1016\/j.actbio.2015.07.019","article-title":"Reprint of: Review of bioactive glass: From Hench to hybrids","volume":"23","author":"Jones","year":"2015","journal-title":"Acta Biomater."},{"key":"ref_4","first-page":"1","article-title":"Clinical Applications of S53P4 Bioactive Glass in Bone Healing and Osteomyelitic Treatment: A Literature Review","volume":"2015","author":"Geurts","year":"2015","journal-title":"Biomed Res. Int."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1007\/s10856-007-3143-1","article-title":"Bactericidal effects of bioactive glasses on clinically important aerobic bacteria","volume":"19","author":"Munukka","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"547","DOI":"10.1007\/s10856-007-3018-5","article-title":"Antibacterial effect of bioactive glasses on clinically important anaerobic bacteria in vitro","volume":"19","author":"Vaahtio","year":"2008","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"475","DOI":"10.1002\/jbm.a.32564","article-title":"Antibacterial effects and dissolution behavior of six bioactive glasses","volume":"93","author":"Zhang","year":"2010","journal-title":"J. Biomed. Mater. Res.-Part A"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1007\/5584_2016_156","article-title":"Antibacterial Bioactive Glass, S53P4, for Chronic Bone Infections\u2014A Multinational Study","volume":"971","author":"Lindfors","year":"2017","journal-title":"Adv. Exp. Med. Biol."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"518","DOI":"10.3109\/17453679808997790","article-title":"Osteomyelitis treated with gentamicin-PMMA beads","volume":"69","author":"Walenkamp","year":"1998","journal-title":"Acta Orthop. Scand."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"S82","DOI":"10.1016\/j.injury.2011.06.189","article-title":"Bone graft substitutes in active or suspected infection. Contra-indicated or not?","volume":"42","author":"Geurts","year":"2011","journal-title":"Injury"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"1121","DOI":"10.1016\/j.jbiomech.2016.02.047","article-title":"Mechanical behaviour of Bioactive Glass granules and morselized cancellous bone allograft in load bearing defects","volume":"49","author":"Hulsen","year":"2016","journal-title":"J. Biomech."},{"key":"ref_12","first-page":"832","article-title":"A survey of micro-finite element analysis for clinical assessment of bone strength: The first decade","volume":"48","author":"Ito","year":"2014","journal-title":"J. Biomech."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"27","DOI":"10.1016\/S0021-9290(03)00257-4","article-title":"Comparison of the elastic and yield properties of human femoral trabecular and cortical bone tissue","volume":"37","author":"Bayraktar","year":"2004","journal-title":"J. Biomech."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"573","DOI":"10.1016\/j.bone.2008.11.015","article-title":"The influence of boundary conditions and loading mode on high-resolution finite element-computed trabecular tissue properties","volume":"44","author":"Bevill","year":"2009","journal-title":"Bone"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"842","DOI":"10.1016\/S8756-3282(02)00736-6","article-title":"Estimation of distal radius failure load with micro-finite element analysis models based on three-dimensional peripheral quantitative computed tomography images","volume":"30","author":"Pistoia","year":"2002","journal-title":"Bone"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1203","DOI":"10.1016\/j.bone.2008.01.017","article-title":"Bone strength at the distal radius can be estimated from high-resolution peripheral quantitative computed tomography and the finite element method","volume":"42","author":"MacNeil","year":"2008","journal-title":"Bone"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"127","DOI":"10.1243\/0954411981533908","article-title":"Mechanical properties of bioactive glasses, glass-ceramics and composites","volume":"212","author":"Thompson","year":"1998","journal-title":"Proc. Inst. Mech. Eng. Part H"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1007\/s11657-014-0183-2","article-title":"Bone microarchitecture and strength of the radius and tibia in a reference population of young adults: an HR-pQCT study","volume":"9","author":"Burt","year":"2014","journal-title":"Arch. Osteoporos."},{"key":"ref_19","unstructured":"Fox, J. (2017). Using the R Commander: A Point-and-Click Interface for R, Chapman and Hall\/CRC Press."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1","DOI":"10.18637\/jss.v014.i09","article-title":"The R Commander: A Basic Statistics Graphical User Interface to R","volume":"14","author":"Fox","year":"2005","journal-title":"J. Stat. Softw."},{"key":"ref_21","unstructured":"Fox, J., and Bouchet-Valat, M. (2019, May 08). Rcmdr: R Commander 2019. Available online: https:\/\/cran.r-project.org\/web\/packages\/Rcmdr\/index.html."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"59","DOI":"10.1055\/s-0029-1214158","article-title":"Osteomyelitis of the long bones","volume":"23","author":"Calhoun","year":"2009","journal-title":"Semin. Plast. Surg."},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Dym, C.L., and Shames, I.H. (2013). Solid Mechanics, Springer New York. Augmented.","DOI":"10.1007\/978-1-4614-6034-3"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"954","DOI":"10.1002\/jor.23721","article-title":"Patient-specific in silico models can quantify primary implant stability in elderly human bone","volume":"36","author":"Steiner","year":"2017","journal-title":"J. Orthop. Res."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"157","DOI":"10.1016\/j.compbiomed.2018.03.012","article-title":"Micro finite element analysis of dental implants under different loading conditions","volume":"96","author":"Wolff","year":"2018","journal-title":"Comput. Biol. Med."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s00223-013-9798-3","article-title":"Precision of High-Resolution Peripheral Quantitative Computed Tomography Measurement Variables: Influence of Gender, Examination Site, and Age","volume":"94","author":"Paggiosi","year":"2014","journal-title":"Calcif. Tissue Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"94","DOI":"10.1007\/s10856-019-6295-x","article-title":"Resorption of the calcium phosphate layer on S53P4 bioactive glass by osteoclasts","volume":"30","author":"Schuiringa","year":"2019","journal-title":"J. Mater. Sci. Mater. Med."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/12\/21\/3481\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T13:29:01Z","timestamp":1760189341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/12\/21\/3481"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2019,10,24]]},"references-count":27,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2019,11]]}},"alternative-id":["ma12213481"],"URL":"https:\/\/doi.org\/10.3390\/ma12213481","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2019,10,24]]}}}