{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,11]],"date-time":"2025-11-11T13:35:10Z","timestamp":1762868110967,"version":"build-2065373602"},"reference-count":78,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T00:00:00Z","timestamp":1583193600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Two-phase implants must be exposed to the external environment after the period of osteointegration has elapsed. For this purpose, a healing abutment is placed passing through the mucosa while forming the emergence profile. The continuous connection and disconnection can lead to an alteration in the tissue maturation, both because of the contact of bacterial plaque and because of the mechanical trauma that involves its manipulation, manifesting with different degrees of erythema or bleeding. To assess whether this epithelium disruption can be counteracted, a blinded study design was developed on 150 unitary implant patients divided into three groups (n = 50), applying chlorhexidine (group 1), ultraviolet C (UV-C) at a wavelength of 254 nm (group 2)and no treatment as a control group (group 3), during each of the disconnections and connections during the prosthodontic treatment (1 time per week for four weeks). All groups showed a better epithelium aspect at the end of the evaluation. Although there were no statistically significant differences in the degree of inflammation, the UV-C treated group had the lowest plaque accumulation, and the highest was for the chlorhexidine-treated group.<\/jats:p>","DOI":"10.3390\/ma13051124","type":"journal-article","created":{"date-parts":[[2020,3,3]],"date-time":"2020-03-03T13:06:23Z","timestamp":1583240783000},"page":"1124","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Control of Peri-Implant Mucous Inflammation by Using Chlorhexidine or Ultraviolet C Radiation for Cleaning Healing Abutments. Double-Blind Randomized Clinical Trial"],"prefix":"10.3390","volume":"13","author":[{"given":"Arturo","family":"Sanchez-Perez","sequence":"first","affiliation":[{"name":"D.D.S., Department of Periodontology, Medicine and Dentistry Faculty, Murcia University, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6679-9431","authenticated-orcid":false,"given":"Ana I.","family":"Nicolas-Silvente","sequence":"additional","affiliation":[{"name":"D.D.S., Department of Restorative Dentistry, Medicine and Dentistry Faculty, Murcia University, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Carmen","family":"Sanchez-Matas","sequence":"additional","affiliation":[{"name":"D.D.S., Virgen del Rocio Hospital, 41013 Sevilla, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Elena","family":"Cascales-Pina","sequence":"additional","affiliation":[{"name":"D.D.S., Department of Periodontology, Medicine and Dentistry Faculty, Murcia University, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vanesa","family":"Macia-Manresa","sequence":"additional","affiliation":[{"name":"D.D.S., Department of Periodontology, Medicine and Dentistry Faculty, Murcia University, 30008 Murcia, Spain"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7745-5957","authenticated-orcid":false,"given":"Georgios E.","family":"Romanos","sequence":"additional","affiliation":[{"name":"D.D.S., Department of Periodontology, School of Dental Medicine, Stony Brook University, Stony Brook, NY 11794-8712, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,3,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1034\/j.1600-0501.1991.020206.x","article-title":"The Soft TissueBarrier at Implants and Teeth","volume":"2","author":"Berglundh","year":"1991","journal-title":"Clin. Oral Implants Res."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"177","DOI":"10.4317\/medoral.19329","article-title":"Soft Tissue Cell Adhesion to Titanium Abutments after Different Cleaning Procedures: Preliminary Results of a Randomized Clinical Trial","volume":"19","author":"Canullo","year":"2014","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1372","DOI":"10.1902\/jop.2001.72.10.1372","article-title":"Influence of the Size of the Microgap on Crestal Bone Changes around Titanium Implants. A Histometric Evaluation of Unloaded Non-Submerged Implants in the Canine Mandible","volume":"72","author":"Hermann","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1902\/jop.1997.68.2.186","article-title":"Biologic Width Around Titanium Implants. A Histometric Analysis of the Implanto-Gingival Junction Around Unloaded and Loaded Nonsubmerged Implants in the Canine Mandible","volume":"68","author":"Cochran","year":"1997","journal-title":"J. Periodontol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1117","DOI":"10.1902\/jop.1997.68.11.1117","article-title":"Crestal Bone Changes around Titanium Implants. A Radiographic Evaluation of Unloaded Nonsubmerged and Submerged Implants in the Canine Mandible","volume":"68","author":"Hermann","year":"1997","journal-title":"J. Periodontol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1111","DOI":"10.1902\/jop.2002.73.10.1111","article-title":"Influence of the Size of the Microgap on Crestal Bone Levels in Non-Submerged Dental Implants: A Radiographic Study in the Canine Mandible","volume":"73","author":"King","year":"2002","journal-title":"J. Periodontol."},{"key":"ref_7","first-page":"363","article-title":"Tissue preservation strategies for fostering long-term soft and hard tissue stability","volume":"35","author":"Romanos","year":"2015","journal-title":"Int. J. Perio. Rest. Dent."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1111\/cid.12084","article-title":"Long-term results after subcrestal or crestal placement of delayed loaded implants","volume":"17","author":"Romanos","year":"2015","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"473","DOI":"10.1177\/154405910608500515","article-title":"Peri-Implant Inflammation Defined by the Implant-Abutment Interface","volume":"85","author":"Broggini","year":"2006","journal-title":"J. Dent. Res."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"232","DOI":"10.1177\/154405910308200316","article-title":"Persistent Acute Inflammation at the Implant-Abutment Interface","volume":"82","author":"Broggini","year":"2003","journal-title":"J. Dent. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"165","DOI":"10.1111\/j.1600-0501.2005.01210.x","article-title":"Tissue Alterations at Implant-Supported Single-Tooth Replacements: A 1-Year Prospective Clinical Study","volume":"17","author":"Cardaropoli","year":"2006","journal-title":"Clin. Oral Implants Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"606","DOI":"10.1111\/j.1600-0501.2012.02499.x","article-title":"Microscopical and Chemical Surface Characterization of the Gingival Portion and Connection of an Internal Hexagon Abutment before and after Different Technical Stages of Preparation","volume":"24","author":"Canullo","year":"2013","journal-title":"Clin. Oral Implants Res."},{"key":"ref_13","first-page":"292","article-title":"Microbial Leakage at the Implant\/Abutment Connection Due to Implant Insertion Maneuvers: Cross-Sectional Study 5 Years Post Loading in Healthy Patients","volume":"41","author":"Rossetti","year":"2014","journal-title":"J. Oral Implantol."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"239","DOI":"10.1034\/j.1600-0501.1994.050407.x","article-title":"Microbial Penetration along the Implant Components of the Br\u00e5nemark System. An in Vitro Study","volume":"5","author":"Quirynen","year":"1994","journal-title":"Clin. Oral Implants Res."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"1412","DOI":"10.1902\/jop.2000.71.9.1412","article-title":"Crestal Bone Changes around Titanium Implants. A Histometric Evaluation of Unloaded Non-Submerged and Submerged Implants in the Canine Mandible","volume":"71","author":"Hermann","year":"2000","journal-title":"J. Periodontol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1177\/08959374990130010501","article-title":"Clinical Experience with One-Stage, Non-Submerged Dental Implants","volume":"13","author":"Buser","year":"1999","journal-title":"Adv. Dent. Res."},{"key":"ref_17","first-page":"654","article-title":"Prevention of Bacterial Leakage into and from Prefabricated Screw-Retained Crowns on Implants in vitro","volume":"14","author":"Besimo","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1146","DOI":"10.1902\/jop.2000.72.9.1146","article-title":"Fluids and Microbial Penetration in the Internal Part of Cement-Retained Versus Screw-Retained Implant-Abutment Connections","volume":"72","author":"Piattelli","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1652","DOI":"10.1902\/jop.2001.72.12.1652","article-title":"Internal Contamination of a 2-Component Implant System After Occlusal Loading and Provisionally Luted Reconstruction With or Without a Washer Device","volume":"72","author":"Rimondini","year":"2001","journal-title":"J. Periodontol."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"1078","DOI":"10.1111\/clr.12217","article-title":"Microleakage of the Prosthetic Abutment\/Implant Interface with Internal and External Connection: In Vitro Study","volume":"25","year":"2014","journal-title":"Clin. Oral Implants Res."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"360","DOI":"10.1111\/cid.12589","article-title":"Bacterial Microleakage at the Abutment-Implant Interface, in Vitro Study","volume":"20","author":"Larrucea","year":"2018","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"80S","DOI":"10.1177\/0022034513519800","article-title":"Prosthetic Abutment Height Is a Key Factor in Peri-Implant Marginal Bone Loss","volume":"93","author":"Monje","year":"2014","journal-title":"J. Dent. Res."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"204","DOI":"10.1034\/j.1600-0501.1999.100303.x","article-title":"Chemical Treatment of Machined Titanium Surfaces. An in vitro Study","volume":"10","author":"Krozer","year":"1999","journal-title":"Clin. Oral Implants Res."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"64","DOI":"10.1097\/ID.0000000000000018","article-title":"Effect of Chlorhexidine in Preventing Plaque Biofilm on Healing Abutment: A Crossover Controlled Study","volume":"23","author":"Bressan","year":"2014","journal-title":"Implant Dent."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1034\/j.1600-0501.1993.040103.x","article-title":"The Soft Tissue Response to Titanium Abutments Retrieved from Humans and Reimplanted in Rats. A Light Microscopic Study","volume":"4","author":"Sennerby","year":"1993","journal-title":"Clin. Oral Implants Res."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"738","DOI":"10.1016\/S0278-2391(96)90694-1","article-title":"Effects of Multiple Sterilization on Surface Characteristics and in Vitro Biologic Responses to Titanium","volume":"54","author":"Vezeau","year":"1996","journal-title":"J. Oral Maxillofac. Surg."},{"key":"ref_27","first-page":"360","article-title":"Characterization of Sterilized CP Titanium Implant Surfaces","volume":"5","author":"Keller","year":"1990","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"236","DOI":"10.1097\/00008505-200009030-00009","article-title":"Reuse of Healing Abutments: An in Vitro Model of Plasma Cleaning and Common Sterilization Techniques","volume":"9","author":"Vezeau","year":"2000","journal-title":"Implant Dent."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1002\/jab.770060102","article-title":"Effectiveness of Cleaning Surgical Implants: Quantitative Analysis of Contaminant Removal","volume":"6","author":"Rowland","year":"1995","journal-title":"J. Appl. Biomater. Off. J. Soc. Biomater."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"311","DOI":"10.1034\/j.1600-0501.1996.070402.x","article-title":"Initial Attachment of Human Gingival Fibroblast-like Cells in vitro to Titanium Surfaces Pretreated with Saliva and Serum","volume":"7","author":"Zentner","year":"1996","journal-title":"Clin. Oral Implants Res."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"7","DOI":"10.1111\/j.1600-0757.1998.tb00119.x","article-title":"Titanium\u2014The Material of Choice?","volume":"17","author":"Steinemann","year":"1998","journal-title":"Periodontology"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1097\/00008505-200204000-00018","article-title":"Crestal Bone Loss around Submerged and Exposed Unloaded Dental Implants: A Radiographic and Microbiological Descriptive Study","volume":"11","author":"Barboza","year":"2002","journal-title":"Implant Dent."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"55","DOI":"10.1111\/j.1600-0501.2006.01367.x","article-title":"The Effect of Material Characteristics, of Surface Topography and of Implant Components and Connections on Soft Tissue Integration: A Literature Review","volume":"2","author":"Rompen","year":"2006","journal-title":"Clin. Oral Implants Res."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"General Assembly of the World Medical Association (2014). World Medical Association Declaration of Helsinki: Ethical Principles for Medical Research Involving Human Subjects. J. Am. Coll. Dent., 81, 14\u201318.","DOI":"10.1515\/jwiet-2014-0117"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1111\/j.1399-302X.1987.tb00298.x","article-title":"The microbiota associated with successful or failing osseointegrated titanium implants","volume":"2","author":"Mombelli","year":"1987","journal-title":"Oral Microbiol. Immunol."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"570","DOI":"10.1136\/bmj.313.7057.570","article-title":"Better Reporting of Randomised Controlled Trials: The CONSORT Statement","volume":"313","author":"Altman","year":"1996","journal-title":"BMJ"},{"key":"ref_37","first-page":"169","article-title":"The Influence of Titanium Abutment Surface Roughness on Plaque Accumulation and Gingivitis: Short-Term Observations","volume":"11","author":"Quirynen","year":"1996","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"158","DOI":"10.1034\/j.1600-0501.1993.040307.x","article-title":"Bacterial Colonization of the Internal Part of Two-Stage Implants. An in vivo Study","volume":"4","author":"Quirynen","year":"1993","journal-title":"Clin. Oral Implants Res."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1034\/j.1600-0501.1996.070201.x","article-title":"Bacterial Colonization on Internal Surfaces of Br\u00e5nemark System Implant Components","volume":"7","author":"Persson","year":"1996","journal-title":"Clin. Oral Implants Res."},{"key":"ref_40","first-page":"527","article-title":"Microbial Leakage and Marginal Fit of the Implant-Abutment Interface","volume":"12","author":"Jansen","year":"1997","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"403","DOI":"10.1046\/j.1365-2842.1998.00261.x","article-title":"Bacterial Leakage into and from Prefabricated Screw-Retained Implant-Borne Crowns in vitro","volume":"25","author":"Guindy","year":"1998","journal-title":"J. Oral Rehabil."},{"key":"ref_42","first-page":"94","article-title":"Microleakage at the Abutment-Implant Interface of Osseointegrated Implants: A Comparative Study","volume":"14","author":"Gross","year":"1999","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1111\/j.1600-0757.1998.tb00124.x","article-title":"The Diagnosis and Treatment of Peri-Implantitis","volume":"17","author":"Mombelli","year":"1998","journal-title":"Periodontology"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1034\/j.1600-0501.1990.010101.x","article-title":"Microbiological Features of Stable Osseointegrated Implants Used as Abutments for Overdentures","volume":"1","author":"Mombelli","year":"1990","journal-title":"Clin. Oral Implants Res."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"1466","DOI":"10.1902\/jop.2010.100061","article-title":"Bacterial adhesion on commercially pure titanium and anatase-coated titanium healing screws: An in vivo human study","volume":"81","author":"Scarano","year":"2010","journal-title":"J. Periodontol."},{"key":"ref_46","first-page":"S142","article-title":"Bactercline\u00ae coated implants: Clinical results up to 1 year after loading from a controlled clinical trial","volume":"9","author":"Carinci","year":"2012","journal-title":"Dent. Res. J."},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"677","DOI":"10.1563\/AAID-JOI-D-11-00167","article-title":"Evaluation of Microgap Size and Microbial Leakage in the Connection Area of 4 Abutments with Straumann (ITI) Implant","volume":"38","author":"Rismanchian","year":"2012","journal-title":"J. Oral Implantol."},{"key":"ref_48","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1111\/j.1600-051X.1979.tb02185.x","article-title":"The Angular Bone Defect and Its Relationship to Trauma from Occlusion and Downgrowth of Subgingival Plaque","volume":"6","author":"Waerhaug","year":"1979","journal-title":"J. Clin. Periodontol."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"26","DOI":"10.1111\/j.1600-0765.1979.tb00215.x","article-title":"Ultrastructural Studies of Inflammation Induced in Rats by Injection of Antigen-Antibody Precipitates. Changes in Palatal Bone and Periosteum to a Single Exposure","volume":"14","author":"Garant","year":"1979","journal-title":"J. Periodontal Res."},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"391","DOI":"10.1902\/jop.2003.74.3.391","article-title":"The Contribution of Interleukin-1 and Tumor Necrosis Factor to Periodontal Tissue Destruction","volume":"74","author":"Graves","year":"2003","journal-title":"J. Periodontol."},{"key":"ref_51","doi-asserted-by":"crossref","first-page":"568","DOI":"10.1111\/j.1600-051X.1997.tb00230.x","article-title":"The Mucosal Barrier Following Abutment Dis\/Reconnection. An Experimental Study in Dogs","volume":"24","author":"Abrahamsson","year":"1997","journal-title":"J. Clin. Periodontol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"807","DOI":"10.11607\/jomi.3022","article-title":"The Effect of Healing Abutment Reconnection and Disconnection on Soft and Hard Peri-Implant Tissues: A Short-Term Randomized Controlled Clinical Trial","volume":"28","author":"Koutouzis","year":"2013","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"152","DOI":"10.1111\/prd.12289","article-title":"Implant-abutment Connection as Contributing Factor to Peri-implant Diseases","volume":"81","author":"Koutouzis","year":"2019","journal-title":"Periodontology"},{"key":"ref_54","first-page":"83","article-title":"The Impact of the Type and Configuration of Abutments and Their (Repeated) Removal on the Attachment Level and Marginal Bone","volume":"5","author":"Rompen","year":"2012","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_55","first-page":"373","article-title":"The Influence of Repeated Abutment Changes on Peri-Implant Tissue Stability: 3-Year Post-Loading Results from a Multicentre Randomised Controlled Trial","volume":"10","author":"Bressan","year":"2017","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"814","DOI":"10.1111\/cid.12651","article-title":"The Micromechanical Behavior of Implant-Abutment Connections under a Dynamic Load Protocol","volume":"20","author":"Zipprich","year":"2018","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"20","DOI":"10.1034\/j.1600-0501.1996.070103.x","article-title":"Radiographical and Histological Characteristics of Submerged and Nonsubmerged Titanium Implants. An Experimental Study in the Labrador Dog","volume":"7","author":"Ericsson","year":"1996","journal-title":"Clin. Oral Implants Res."},{"key":"ref_58","first-page":"81","article-title":"Intra-Osseous Anchorage of Dental Prostheses. I. Experimental Studies","volume":"3","author":"Adell","year":"1969","journal-title":"Scand. J. Plast. Reconstr. Surg."},{"key":"ref_59","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1902\/jop.1992.63.3.225","article-title":"Soft Tissue Reactions to Non-Submerged Unloaded Titanium Implants in Beagle Dogs","volume":"63","author":"Buser","year":"1992","journal-title":"J. Periodontol."},{"key":"ref_60","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1034\/j.1600-0501.2001.120502.x","article-title":"Connective Tissue Orientation around Dental Implants in a Canine Model","volume":"12","author":"Comut","year":"2001","journal-title":"Clin. Oral Implants Res."},{"key":"ref_61","doi-asserted-by":"crossref","first-page":"635","DOI":"10.1111\/j.1600-0501.2008.01543.x-i2","article-title":"The Mucosal Barrier at Implant Abutments of Different Materials","volume":"19","author":"Welander","year":"2008","journal-title":"Clin. Oral Implants Res."},{"key":"ref_62","doi-asserted-by":"crossref","first-page":"721","DOI":"10.1111\/j.1600-051X.1998.tb02513.x","article-title":"The Mucosal Attachment at Different Abutments. An Experimental Study in Dogs","volume":"25","author":"Abrahamsson","year":"1998","journal-title":"J. Clin. Periodontol."},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"448","DOI":"10.1034\/j.1600-051X.2002.290510.x","article-title":"The Mucosal Attachment to Titanium Implants with Different Surface Characteristics: An Experimental Study in Dogs","volume":"29","author":"Abrahamsson","year":"2002","journal-title":"J. Clin. Periodontol."},{"key":"ref_64","first-page":"449","article-title":"Influence of Abutment Material on Stability of Peri-Implant Tissues: A Systematic Review","volume":"23","author":"Linkevicius","year":"2008","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"44","DOI":"10.1111\/j.1708-8208.2005.tb00074.x","article-title":"Periimplant Soft Tissue Barrier at Experimental One-Piece Mini-Implants with Different Surface Topography in Humans: A Light-Microscopic Overview and Histometric Analysis","volume":"7","author":"Glauser","year":"2005","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"613","DOI":"10.1902\/jop.2010.100415","article-title":"Bacterial Colonization of the Implant\u2013Abutment Interface Using an in vitro Dynamic Loading Model","volume":"82","author":"Koutouzis","year":"2011","journal-title":"J. Periodontol."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"971","DOI":"10.1111\/j.1600-051X.1996.tb00520.x","article-title":"Dimension of the Periimplant Mucosa. Biological Width Revisited","volume":"23","author":"Berglundh","year":"1996","journal-title":"J. Clin. Periodontol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"218","DOI":"10.1034\/j.1600-0501.1998.090402.x","article-title":"Evaluation of Postsurgical Crestal Bone Levels Adjacent to Non-Submerged Dental Implants","volume":"9","author":"Huber","year":"1998","journal-title":"Clin. Oral Implants Res."},{"key":"ref_69","first-page":"285","article-title":"Immediate Positioning of a Definitive Abutment versus Repeated Abutment Replacements in Post-Extractive Implants: 3-Year Follow-up of a Randomised Multicentre Clinical Trial","volume":"3","author":"Canullo","year":"2010","journal-title":"Eur. J. Oral Implantol."},{"key":"ref_70","first-page":"1","article-title":"Chlorhexidine mouthrinse as an adjunctive treatment for gingival health","volume":"3","author":"James","year":"2017","journal-title":"Cochrane Database Syst. Rev."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"1419","DOI":"10.1902\/jop.2008.070660","article-title":"Internal Decontamination of Dental Implants: An in Vivo Randomized Microbiologic 6-Month Trial on the Effects of a Chlorhexidine Gel","volume":"79","author":"Paolantonio","year":"2008","journal-title":"J. Periodontol."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"5326340","DOI":"10.1155\/2018\/5326340","article-title":"Peri-Implant Bone Resorption during Healing Abutment Placement: The Effect of a 0.20% Chlorhexidine Gel vs. Placebo\u2014A Randomized Double Blind Controlled Human Study","volume":"2018","author":"Sinjari","year":"2018","journal-title":"Biomed. Res. Int."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1111\/cid.12270","article-title":"Bacterial Composition at the Implant-Abutment Connection under Loading in Vivo","volume":"18","author":"Romanos","year":"2016","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"884","DOI":"10.1111\/cid.12065","article-title":"Immediately loaded platform-switched implants in the anterior mandible with fixed prostheses: A randomized, split-mouth, masked prospective trial","volume":"16","author":"Romanos","year":"2014","journal-title":"Clin. Implant Dent. Relat. Res."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"809","DOI":"10.1902\/jop.2016.150684","article-title":"Antimicrobial Agents Used in the Treatment of Peri-Implantitis Alter the Physicochemistry and Cytocompatibility of Titanium Surfaces","volume":"87","author":"Kotsakis","year":"2016","journal-title":"J. Periodontol."},{"key":"ref_76","first-page":"49","article-title":"Ultraviolet Light Treatment for the Restoration of Age-Related Degradation of Titanium Bioactivity","volume":"25","author":"Hori","year":"2010","journal-title":"Int. J. Oral Maxillofac. Implants"},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"2717","DOI":"10.1016\/j.biomaterials.2009.12.024","article-title":"Enhancement of Osteoblast Adhesion to UV-Photofunctionalized Titanium via an Electrostatic Mechanism","volume":"31","author":"Iwasa","year":"2010","journal-title":"Biomaterials"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"57","DOI":"10.11607\/jomi.2638","article-title":"The Effect of Ultraviolet-C Irradiation via a Bactericidal Ultraviolet Sterilizer on an Anodized Titanium Implant: A Study in Rabbits","volume":"28","author":"Park","year":"2013","journal-title":"Int. J. Oral Maxillofac. 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