{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,13]],"date-time":"2026-10-13T09:27:59Z","timestamp":1791883679518,"version":"4.3.4"},"reference-count":35,"publisher":"MDPI AG","issue":"13","license":[{"start":{"date-parts":[[2020,7,1]],"date-time":"2020-07-01T00:00:00Z","timestamp":1593561600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/100008061","name":"Fundaci\u00f3n Mutua Madrile\u00f1a","doi-asserted-by":"publisher","award":["04078\/001"],"award-info":[{"award-number":["04078\/001"]}],"id":[{"id":"10.13039\/100008061","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100003329","name":"Ministerio de Econom\u00eda y Competitividad","doi-asserted-by":"publisher","award":["BES-2014-069007"],"award-info":[{"award-number":["BES-2014-069007"]}],"id":[{"id":"10.13039\/501100003329","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The aim of this study was to evaluate the effectiveness of a moxifloxacin-loaded organic\u2013inorganic sol-gel (A50) by locally preventing the catheter-related bloodstream infection (CRBSI) provoked by Staphylococcus epidermidis (S. epidermidis) and the effect resulting from its hydrolytic degradation on coagulation by using a rabbit in-vivo model. A50 coating can completely inhibit growth and would locally prevent CRBSI provoked by S. epidermidis. None of the coagulation blood parameters showed a significant difference constant over time between the control catheter group and the A50-coated catheter group, despite the visible silica release resulting from physiological A50 sol-gel degradation detected in serum at least during the first week. At pathological level, foreign body reaction was present in both of types of catheter, and it was characterized by the presence of macrophages and foreign body giant cell. However, this reaction was different in each group: the A50-coated catheter group showed a higher inflammation with histiocytes, which were forming granuloma-like aggregates with an amorphous crystalline material inside, accompanied by other inflammatory cells such as plasma cells, lymphocytes and mast cells. In conclusion, A50 coating a venous catheter showed excellent bactericidal anti-biofilm response since it completely inhibited S. epidermidis biofilm development and, far from showing procoagulant effects, showed slightly anticoagulant effects.<\/jats:p>","DOI":"10.3390\/ma13132946","type":"journal-article","created":{"date-parts":[[2020,7,2]],"date-time":"2020-07-02T02:44:25Z","timestamp":1593657865000},"page":"2946","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["A New Antibiotic-Loaded Sol-Gel can Prevent Bacterial Intravenous Catheter-Related Infections"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-4002-1944","authenticated-orcid":false,"given":"John Jairo","family":"Aguilera-Correa","sequence":"first","affiliation":[{"name":"Clinical Microbiology Department, IIS-Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rosa","family":"Vidal-Laso","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy, IIS- Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rafael Alfredo","family":"Carias-C\u00e1lix","sequence":"additional","affiliation":[{"name":"Pathology Department, Fundacion Jimenez Diaz University Hospital, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Beatriz","family":"Toirac","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, University Carlos III, 28911 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Amaya","family":"Garc\u00eda-Casas","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, University Carlos III, 28911 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Diego","family":"Velasco-Rodr\u00edguez","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy, IIS- Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Pilar","family":"Llamas-Sillero","sequence":"additional","affiliation":[{"name":"Hematology and Hemotherapy, IIS- Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9861-2309","authenticated-orcid":false,"given":"Antonia","family":"Jim\u00e9nez-Morales","sequence":"additional","affiliation":[{"name":"Materials Science and Engineering Department, University Carlos III, 28911 Madrid, Spain"},{"name":"\u00c1lvaro Alonso Barba Technological Institute of Chemistry and Materials, Carlos III University, 28911 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8971-3167","authenticated-orcid":false,"given":"Jaime","family":"Esteban","sequence":"additional","affiliation":[{"name":"Clinical Microbiology Department, IIS-Fundacion Jimenez Diaz, UAM, 28040 Madrid, Spain"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,7,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"530","DOI":"10.1002\/jhm.2389","article-title":"International prevalence of the use of peripheral intravenous catheters","volume":"10","author":"Alexandrou","year":"2015","journal-title":"J. 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