{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,1]],"date-time":"2026-05-01T10:28:32Z","timestamp":1777631312412,"version":"3.51.4"},"reference-count":64,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T00:00:00Z","timestamp":1594339200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"This work was supported by a grant of the Romanian Ministery of Research and Innovation, CCCDI \u2013 UEFISCDI","award":["project number PN-III-P1-1.2-PCCDI-2017-0239 \/ 60PCCDI 2018 , within PNCDI III"],"award-info":[{"award-number":["project number PN-III-P1-1.2-PCCDI-2017-0239 \/ 60PCCDI 2018 , within PNCDI III"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>In recent years, biodegradable Mg-based materials have been increasingly studied to be used in the medical industry and beyond. A way to improve biodegradability rate in sync with the healing process of the natural human bone is to alloy Mg with other biocompatible elements. The aim of this research was to improve biodegradability rate and biocompatibility of Mg-0.5Ca alloy through addition of Y in 0.5\/1.0\/1.5\/2.0\/3.0wt.%. To characterize the chemical composition and microstructure of experimental Mg alloys, scanning electron microscopy (SEM), energy-dispersive spectroscopy (EDS), light microscopy (LM), and X-ray diffraction (XRD) were used. The linear polarization resistance (LPR) method was used to calculate corrosion rate as a measure of biodegradability rate. The cytocompatibility was evaluated by MTT assay (3-(4,5-dimethylthiazole-2-yl)-2,5-diphenyltetrazolium bromide) and fluorescence microscopy. Depending on chemical composition, the dendritic \u03b1-Mg solid solution, as well as lamellar Mg2Ca and Mg24Y5 intermetallic compounds were found. The lower biodegradability rates were found for Mg-0.5Ca-2.0Y and Mg-0.5Ca-3.0Y which have correlated with values of cell viability. The addition of 2\u20133 wt.%Y in the Mg-0.5Ca alloy improved both the biodegradability rate and cytocompatibility behavior.<\/jats:p>","DOI":"10.3390\/ma13143082","type":"journal-article","created":{"date-parts":[[2020,7,10]],"date-time":"2020-07-10T09:25:28Z","timestamp":1594373128000},"page":"3082","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":13,"title":["Electrochemical Analysis and In Vitro Assay of Mg-0.5Ca-xY Biodegradable Alloys"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-3523","authenticated-orcid":false,"given":"Bogdan","family":"Istrate","sequence":"first","affiliation":[{"name":"Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3878-9129","authenticated-orcid":false,"given":"Corneliu","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-8130","authenticated-orcid":false,"given":"Stefan","family":"Lupescu","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Romeu","family":"Chelariu","sequence":"additional","affiliation":[{"name":"Faculty of Material Science and Engineering Department, Gheorghe Asachi University of Iasi, 41 DimitrieMangeron str., 700050 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria Daniela","family":"Vlad","sequence":"additional","affiliation":[{"name":"Faculty of Medical Bioengineering, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy from Iasi, 9-13 Kog\u0103lniceanu Str, 700454 Iasi, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3593-9400","authenticated-orcid":false,"given":"Petric\u0103","family":"Vizureanu","sequence":"additional","affiliation":[{"name":"Faculty of Material Science and Engineering Department, Gheorghe Asachi University of Iasi, 41 DimitrieMangeron str., 700050 Iasi, Romania"},{"name":"Romanian Inventors Forum, Sf. P. 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