{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,2]],"date-time":"2026-07-02T23:37:09Z","timestamp":1783035429914,"version":"3.54.6"},"reference-count":76,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T00:00:00Z","timestamp":1600041600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>A series of new benzofuryl \u03b1-azole ketones was synthesized and reduced by asymmetric transfer hydrogenation (ATH). Novel benzofuryl \u03b2-amino alcohols bearing an imidazolyl and triazolyl substituents were obtained with excellent enantioselectivity (96\u201399%). The absolute configuration (R) of the products was confirmed by means of electronic circular dichroism (ECD) spectroscopy supported by theoretical calculations. Selected benzofuryl \u03b1-azole ketones were also successfully asymmetrically bioreduced by fungi of Saccharomyces cerevisiae and Aureobasidium pullulans species. Racemic and chiral \u03b2-amino alcohols, as well as benzofuryl \u03b1-amino and \u03b1-bromo ketones were evaluated for their antibacterial and antifungal activities. From among the synthesized \u03b2-amino alcohols, the highest antimicrobial activity was found for (R)-1-(3,5-dimethylbenzofuran-2-yl)-2-(1H-imidazol-1-yl)ethan-1-ol against S. aureus ATCC 25923 (MIC = 64, MBC = 96 \u03bcg mL\u22121) and (R)-1-(3,5-dimethylbenzofuran-2-yl)-2-(1H-1,2,4-triazol-1-yl)ethan-1-ol against yeasts of M. furfur DSM 6170 (MIC = MBC = 64 \u03bcg mL\u22121). In turn, from among the tested ketones, 1-(benzofuran-2-yl)-2-bromoethanones (1\u20134) were found to be the most active against M. furfur DSM 6170 (MIC = MBC = 1.5 \u03bcg mL\u22121) (MIC\u2014minimal inhibitory concentration, MBC\u2014minimal biocidal concentration).<\/jats:p>","DOI":"10.3390\/ma13184080","type":"journal-article","created":{"date-parts":[[2020,9,14]],"date-time":"2020-09-14T09:04:53Z","timestamp":1600074293000},"page":"4080","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":7,"title":["Synthesis, Absolute Configuration, Antibacterial, and Antifungal Activities of Novel Benzofuryl \u03b2-Amino Alcohols"],"prefix":"10.3390","volume":"13","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-2015-7510","authenticated-orcid":false,"given":"Agnieszka","family":"Tafelska-Kaczmarek","sequence":"first","affiliation":[{"name":"Department of Organic Chemistry, Faculty of Chemistry, Nicolaus Copernicus University in Toru\u0144, 7 Gagarin Street, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Renata","family":"Ko\u0142odziejska","sequence":"additional","affiliation":[{"name":"Department of Medical Biology and Biochemistry, Faculty of Medicine, Nicolaus Copernicus University in Toru\u0144, Collegium Medicum in Bydgoszcz, 24 Kar\u0142owicz Street, 85-092 Bydgoszcz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7830-4560","authenticated-orcid":false,"given":"Marcin","family":"Kwit","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, 8 Uniwersytetu Pozna\u0144skiego Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bartosz","family":"Stasiak","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, Adam Mickiewicz University, 8 Uniwersytetu Pozna\u0144skiego Street, 61-614 Pozna\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Magdalena","family":"Wypij","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University in Toru\u0144, 1 Lwowska Street, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9154-8191","authenticated-orcid":false,"given":"Patrycja","family":"Goli\u0144ska","sequence":"additional","affiliation":[{"name":"Department of Microbiology, Faculty of Biology and Veterinary Sciences, Nicolaus Copernicus University in Toru\u0144, 1 Lwowska Street, 87-100 Toru\u0144, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"483","DOI":"10.1016\/j.ejmech.2014.11.039","article-title":"Bioactive benzofuran derivatives: A review","volume":"97","author":"Shamsuzzaman","year":"2015","journal-title":"Eur. 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