{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,21]],"date-time":"2026-09-21T20:41:56Z","timestamp":1790023316044,"version":"4.0.1"},"reference-count":53,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,9,27]],"date-time":"2020-09-27T00:00:00Z","timestamp":1601164800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Aim: This systematic review and meta-analysis aims to assess the additive effect of leukocyte and platelet-rich fibrin (L-PRF) on coronally advanced flap (CAF) procedures in root coverage of Miller\u2019s class I and II gingival recession defects. Review methodology: A comprehensive search in MEDLINE (PubMed), Scopus and CENTRAL (the Cochrane Central Register of Controlled Trials), along with an additional hand search, provided eight randomized clinical trials to be included in this review. A total of 167 patients with 470 gingival recession defects were analyzed. A meta-analysis was carried out to assess the change in gingival thickness (GT), width of keratinized gingiva (WKG), root coverage percentage (%RC), clinical attachment level (CAL) and recession depth (RD) at all follow-ups between CAF alone and CAF + L-PRF groups for all included studies. A subgroup analysis was carried out based on recession type (single\/multiple). Results: Overall, a significant improvement in GT, CAL and RD was found when treated with CAF + L-PRF. There was a trend for a positive effect in terms of an increase in WKG when using L-PRF, especially in the treatment of single recession, though significance was not achieved (p = 0.08 overall). The results of heterogeneity among the subgroups were varied and were found to be greater than 91.3% for GT and 32.8% for WKG. Conclusion: L-PRF when used in addition to CAF showed favorable results for the treatment of class I and II gingival recession defects.<\/jats:p>","DOI":"10.3390\/ma13194314","type":"journal-article","created":{"date-parts":[[2020,9,28]],"date-time":"2020-09-28T08:02:58Z","timestamp":1601280178000},"page":"4314","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":21,"title":["Additive Effect of Platelet Rich Fibrin with Coronally Advanced Flap Procedure in Root Coverage of Miller\u2019s Class I and II Recession Defects\u2014A PRISMA Compliant Systematic Review and Meta-Analysis"],"prefix":"10.3390","volume":"13","author":[{"given":"Saurav","family":"Panda","sequence":"first","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"},{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 degli Studi di Milano, 20122 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5648-4281","authenticated-orcid":false,"given":"Anurag","family":"Satpathy","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7832-3406","authenticated-orcid":false,"given":"Abhaya","family":"Chandra Das","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Manoj","family":"Kumar","sequence":"additional","affiliation":[{"name":"Department of Periodontics and Oral Implantology, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8680-2172","authenticated-orcid":false,"given":"Lora","family":"Mishra","sequence":"additional","affiliation":[{"name":"Department of Conservative Dentistry and Endodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1088-2265","authenticated-orcid":false,"given":"Swati","family":"Gupta","sequence":"additional","affiliation":[{"name":"Private Practice, Gainesville, FL 32603, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gunjan","family":"Srivastava","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Institute of Dental Sciences, Siksha \u2018O\u2019 Anusandhan University, Bhubaneswar 751003, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6110-4298","authenticated-orcid":false,"given":"Monika","family":"Lukomska-Szymanska","sequence":"additional","affiliation":[{"name":"Department of General Dentistry, Medical University of Lodz, 92-213 Lodz, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7866-5024","authenticated-orcid":false,"given":"Silvio","family":"Taschieri","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 degli Studi di Milano, 20122 Milano, Italy"},{"name":"Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, 20161 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7144-0984","authenticated-orcid":false,"given":"Massimo","family":"Del Fabbro","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Surgical and Dental Sciences, Universit\u00e0 degli Studi di Milano, 20122 Milano, Italy"},{"name":"Dental Clinic, IRCCS Istituto Ortopedico Galeazzi, 20161 Milano, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2020,9,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"18","DOI":"10.1590\/2177-6709.21.3.018-029.oin","article-title":"Gingival recession: Its causes and types, and the importance of orthodontic treatment","volume":"21","author":"Jati","year":"2016","journal-title":"Dent. 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Rep."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/13\/19\/4314\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T10:14:16Z","timestamp":1760177656000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/13\/19\/4314"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2020,9,27]]},"references-count":53,"journal-issue":{"issue":"19","published-online":{"date-parts":[[2020,10]]}},"alternative-id":["ma13194314"],"URL":"https:\/\/doi.org\/10.3390\/ma13194314","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2020,9,27]]}}}