{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T22:39:17Z","timestamp":1778279957407,"version":"3.51.4"},"reference-count":41,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T00:00:00Z","timestamp":1601683200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Federation State Task N 075-00947-20-00","award":["075-00947-20-00"],"award-info":[{"award-number":["075-00947-20-00"]}]},{"name":"Subsidy allocated to Kazan Federal University for the state assignment","award":["0671-2020-0051"],"award-info":[{"award-number":["0671-2020-0051"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Bioactive manganese (Mn)-doped ceramic coatings for intraosseous titanium (Ti) implants are developed. Arc plasma deposition procedure is used for coatings preparation. X-ray Diffraction, Scanning Electron Microscopy-Energy Dispersive X-ray Spectroscopy, and Electron Paramagnetic Resonance (EPR) methods are applied for coatings characterization. The coatings are homogeneous, composed of the main phase \u03b1-tricalcium phosphate (\u03b1-TCP) (about 67%) and the minor phase hydroxyapatite (about 33%), and the Mn content is 2.3 wt%. EPR spectroscopy demonstrates that the Mn ions are incorporated in the TCP structure and are present in the coating in Mn2+ and Mn3+ oxidation states, being aggregated in clusters. The wetting contact angle of the deposited coatings is suitable for cells\u2019 adhesion and proliferation. In vitro soaking in physiological solution for 90 days leads to a drastic change in phase composition; the transformation into calcium carbonate and octacalcium phosphate takes place, and no more Mn is present. The absence of antibacterial activity against Escherichia coli, Enterococcus faecalis, and Pseudomonas aeruginosa bacteria strains is observed. A study of the metabolic activity of mouse fibroblasts of the NCTC L929 cell line on the coatings using the MTT (dye compound 3-(4,5-Dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide) test demonstrates that there is no toxic effect on the cell culture. Moreover, the coating material supports the adhesion and proliferation of the cells. A good adhesion, spreading, and proliferative activity of the human tooth postnatal dental pulp stem cells (DPSC) is demonstrated. The developed coatings are promising for implant application in orthopedics and dentistry.<\/jats:p>","DOI":"10.3390\/ma13194411","type":"journal-article","created":{"date-parts":[[2020,10,3]],"date-time":"2020-10-03T07:22:16Z","timestamp":1601709736000},"page":"4411","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":43,"title":["In Vitro Properties of Manganese-Substituted Tricalcium Phosphate Coatings for Titanium Biomedical Implants Deposited by Arc Plasma"],"prefix":"10.3390","volume":"13","author":[{"given":"Inna V.","family":"Fadeeva","sequence":"first","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Vasilii I.","family":"Kalita","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5747-6411","authenticated-orcid":false,"given":"Dmitry I.","family":"Komlev","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5771-1888","authenticated-orcid":false,"given":"Alexei A.","family":"Radiuk","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7554-3294","authenticated-orcid":false,"given":"Alexander S.","family":"Fomin","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina A.","family":"Davidova","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics of Russian Academy of Sciences, Institutskaya 3, Puschino, 142290 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6053-2621","authenticated-orcid":false,"given":"Nadezhda K.","family":"Fursova","sequence":"additional","affiliation":[{"name":"Federal Budget Institution of Science State Scientific Center of Applied Microbiology and Biotechnology, 24 block A, Obolensk, Serpukhov, 142279 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7601-6314","authenticated-orcid":false,"given":"Fadis F.","family":"Murzakhanov","sequence":"additional","affiliation":[{"name":"Institute of Physics, Kazan Federal University, Kremlevskaya 18, 420008 Kazan, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2179-2823","authenticated-orcid":false,"given":"Marat R.","family":"Gafurov","sequence":"additional","affiliation":[{"name":"Institute of Physics, Kazan Federal University, Kremlevskaya 18, 420008 Kazan, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marco","family":"Fosca","sequence":"additional","affiliation":[{"name":"Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0112-3494","authenticated-orcid":false,"given":"Iulian V.","family":"Antoniac","sequence":"additional","affiliation":[{"name":"Faculty of Materials Science and Engineering, Politehnica University of Bucharest, 313 Splaiul Independentei, District 6, 060042 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Sergey M.","family":"Barinov","sequence":"additional","affiliation":[{"name":"A.A. Baikov Institute of Metallurgy and Material Science Russian Academy of Sciences, Leninsky, 49, 119334 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-1853","authenticated-orcid":false,"given":"Julietta V.","family":"Rau","sequence":"additional","affiliation":[{"name":"Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere 100, 00133 Rome, Italy"},{"name":"Department of Analytical, Physical and Colloid Chemistry, Institute of Pharmacy, Sechenov First Moscow State Medical University, Trubetskaya 8, Build. 2, 119991 Moscow, Russian"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2020,10,3]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1002\/art.23525","article-title":"Changes in surgical loads and economic burden of hip and knee replacements in the US: 1997\u20132004","volume":"59","author":"Kim","year":"2008","journal-title":"Arthritis Rheum."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.1086\/374554","article-title":"Prosthetic joint infections: Bane of orthopedists, challenge for infectious disease specialists","volume":"36","author":"Lentino","year":"2003","journal-title":"Clin. 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