{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,8]],"date-time":"2026-05-08T18:44:33Z","timestamp":1778265873406,"version":"3.51.4"},"reference-count":54,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2021,6,13]],"date-time":"2021-06-13T00:00:00Z","timestamp":1623542400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Bialystok University of Technology and financed from the funds for Science, Ministry of Science and Higher Education of Poland.","award":["WZ\/WB-IIS\/5\/2020"],"award-info":[{"award-number":["WZ\/WB-IIS\/5\/2020"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Dacarbazine (DAC) 5-(3,3-dimethyl-1-triazenyl)imidazole-4-carboxamide is an imidazole-carboxamide derivative that is structurally related to purines. DAC belongs to the triazene compounds, which are a group of alkylating agents with antitumor and mutagenic properties. DAC is a non-cell cycle specific drug, active in all phases of the cellular cycle. In the frame of this work the 3d metal complexes (cobalt and copper) with dacarbazine were synthesized. Their spectroscopic properties by the use of FT-IR, FT-Raman, and 1HNMR were studied. The structures of dacarbazine and its complexes with copper(II) and cobalt(II) were calculated using DFT methods. The effect of metals on the electronic charge distribution of dacarbazine was discussed on the basis of calculated NBO atomic charges. The reactivity of metal complexes in relation to ligand alone was estimated on the basis of calculated energy of HOMO and LUMO orbitals. The aromaticity of the imidazole ring in dacarbazine and the complexes were compared (on the basis of calculated geometric indices of aromaticity). Thermal stability of the investigated 3d-metal complexes with dacarbazine and the products of their thermal decomposition were analyzed.<\/jats:p>","DOI":"10.3390\/ma14123274","type":"journal-article","created":{"date-parts":[[2021,6,14]],"date-time":"2021-06-14T22:25:46Z","timestamp":1623709546000},"page":"3274","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Synthesis, Spectroscopic, and Theoretical Study of Copper and Cobalt Complexes with Dacarbazine"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-6348","authenticated-orcid":false,"given":"Grzegorz","family":"\u015awiderski","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska Street 45E, 15-351 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ryszard","family":"\u0141a\u017any","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Bialystok, Ciolkowskiego Street 1K, 15-245 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Micha\u0142","family":"Sienkiewicz","sequence":"additional","affiliation":[{"name":"Faculty of Chemistry, University of Bialystok, Ciolkowskiego Street 1K, 15-245 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-9891","authenticated-orcid":false,"given":"Monika","family":"Kalinowska","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska Street 45E, 15-351 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7034-9126","authenticated-orcid":false,"given":"Renata","family":"\u015awis\u0142ocka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska Street 45E, 15-351 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ali Osman","family":"Acar","sequence":"additional","affiliation":[{"name":"Material Science and Nanotechnology Engineering, TOBB University of Economics and Technology, 06-560 Ankara, Turkey"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8387-7961","authenticated-orcid":false,"given":"Aleksandra","family":"Golonko","sequence":"additional","affiliation":[{"name":"Institute of Agricultural and Food Biotechnology, Department of Microbiology, Rakowiecka 36, 02-532 Warsaw, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marzena","family":"Matejczyk","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska Street 45E, 15-351 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"W\u0142odzimierz","family":"Lewandowski","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Bialystok University of Technology, Wiejska Street 45E, 15-351 Bialystok, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,6,13]]},"reference":[{"key":"ref_1","first-page":"21","article-title":"Dacarbazine-based chemotherapy for metastatic melanoma: Thirty-year experience overview","volume":"19","author":"Serrone","year":"2000","journal-title":"J. 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