{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,17]],"date-time":"2026-10-17T05:29:11Z","timestamp":1792214951859,"version":"4.4.0"},"reference-count":97,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T00:00:00Z","timestamp":1628726400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>In this review, we describe the application of thermosensitive hydrogels composed of poloxamer in medicine, especially for oral cavities. Thermosensitive hydrogels remain fluid at room temperature; at body temperature, they become more viscous gels. In this manner, the gelling system can remain localized for considerable durations and control and prolong drug release. The chemical structure of the poloxamer triblock copolymer leads to an amphiphilic aqueous solution and an active surface. Moreover, the poloxamer can gel by forming micelles in an aqueous solution, depending on its critical micelle concentration and critical micelle temperature. Owing to its controlled-release effect, a thermosensitive gel based on poloxamer 407 (P407) is used to deliver drugs with different characteristics. As demonstrated in studies on poloxamer formulations, an increase in gelling viscosity decreases the drug release rate and gel dissolution time to the extent that it prolongs the drug\u2019s duration of action in disease treatment. This property is used for drug delivery and different therapeutic applications. Its unique route of administration, for many oral diseases, is advantageous over traditional routes of administration, such as direct application and systemic treatment. In conclusion, thermosensitive gels based on poloxamers are suitable and have great potential for oral disease treatment.<\/jats:p>","DOI":"10.3390\/ma14164522","type":"journal-article","created":{"date-parts":[[2021,8,12]],"date-time":"2021-08-12T10:54:41Z","timestamp":1628765681000},"page":"4522","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":131,"title":["An Overview on Thermosensitive Oral Gel Based on Poloxamer 407"],"prefix":"10.3390","volume":"14","author":[{"given":"Yabing","family":"Chen","sequence":"first","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jeong-Ho","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mingyue","family":"Meng","sequence":"additional","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Naiyu","family":"Cui","sequence":"additional","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chun-Yu","family":"Dai","sequence":"additional","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6355-8656","authenticated-orcid":false,"given":"Qi","family":"Jia","sequence":"additional","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eui-Seok","family":"Lee","sequence":"additional","affiliation":[{"name":"Department of Oral and Maxillofacial Surgery, Graduate School of Clinical Dentistry, Korea University, Seoul 08308, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2514-2633","authenticated-orcid":false,"given":"Heng-Bo","family":"Jiang","sequence":"additional","affiliation":[{"name":"Stomatological Materials Laboratory, School of Stomatology, Shandong First Medical University & Shandong Academy of Medical Sciences, Tai\u2019an 271016, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,12]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Giuliano, E., Paolino, D., Fresta, M., and Cosco, D. (2018). Mucosal Applications of Poloxamer 407-Based Hydrogels: An Overview. Pharmaceutics, 10.","DOI":"10.3390\/pharmaceutics10030159"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"409","DOI":"10.1016\/j.ejpb.2004.03.019","article-title":"In situ-forming hydrogels\u2014Review of temperature-sensitive systems","volume":"58","author":"Leroux","year":"2004","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.actbio.2020.04.028","article-title":"Poloxamer: A versatile tri-block copolymer for biomedical applications","volume":"110","author":"Zarrintaj","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Russo, E., and Villa, C. (2019). Poloxamer Hydrogels for Biomedical Applications. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11120671"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"412","DOI":"10.1016\/S0167-7799(00)01485-2","article-title":"Poloxamers and poloxamines in nanoparticle engineering and experimental medicine","volume":"18","author":"Moghimi","year":"2000","journal-title":"Trends Biotechnol."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"2103","DOI":"10.1208\/s12249-018-1010-7","article-title":"Thermosensitive Poloxamer 407\/Poly(Acrylic Acid) Hydrogels with Potential Application as Injectable Drug Delivery System","volume":"19","author":"Boonlai","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"199","DOI":"10.1016\/j.ejpb.2008.04.025","article-title":"A novel poloxamers\/hyaluronic acid in situ forming hydrogel for drug delivery: Rheological, mucoadhesive and in vitro release properties","volume":"70","author":"Mayol","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"105125","DOI":"10.1016\/j.ejps.2019.105125","article-title":"Development and characterization of mucoadhesive-thermoresponsive gels for the treatment of oral mucosa diseases","volume":"142","author":"Pagano","year":"2020","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"101","DOI":"10.4103\/jphi.JPHI_26_17","article-title":"Thermoreversible in situ gel for subgingival delivery of simvastatin for treatment of periodontal disease","volume":"7","author":"Rajendran","year":"2017","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"434","DOI":"10.1007\/s13346-018-0488-6","article-title":"Investigation on solution-to-gel characteristic of thermosensitive and mucoadhesive biopolymers for the development of moxifloxacin-loaded sustained release periodontal in situ gels","volume":"9","author":"Sheshala","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"190","DOI":"10.1016\/j.jobcr.2019.04.001","article-title":"Development of Moxifloxacin Hydrochloride loaded in-situ gel for the treatment of periodontitis: In-vitro drug release study and antibacterial activity","volume":"9","author":"Swain","year":"2019","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2709","DOI":"10.1007\/s11095-006-9104-4","article-title":"A review of poloxamer 407 pharmaceutical and pharmacological characteristics","volume":"23","author":"Dumortier","year":"2006","journal-title":"Pharm. Res."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"1017","DOI":"10.1007\/s13346-019-00639-w","article-title":"Chlorpheniramine maleate containing chitosan-based nanoparticle-loaded thermosensitive in situ gel for management in allergic rhinitis","volume":"9","author":"Kumar","year":"2019","journal-title":"Drug Deliv. Transl. Res."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.jconrel.2007.05.009","article-title":"Poly(N-isopropylacrylamide)-chitosan as thermosensitive in situ gel-forming system for ocular drug delivery","volume":"120","author":"Cao","year":"2007","journal-title":"J. Control. Release"},{"key":"ref_15","doi-asserted-by":"crossref","unstructured":"Zambanini, T., Borges, R., de Souza, A.C.S., Justo, G.Z., Machado, J., de Araujo, D.R., and Marchi, J. (2021). Holmium-Containing Bioactive Glasses Dispersed in Poloxamer 407 Hydrogel as a Theragenerative Composite for Bone Cancer Treatment. Materials, 14.","DOI":"10.3390\/ma14061459"},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"245","DOI":"10.1016\/j.carbpol.2016.02.059","article-title":"Modified chitosan thermosensitive hydrogel enables sustained and efficient anti-tumor therapy via intratumoral injection","volume":"144","author":"Jiang","year":"2016","journal-title":"Carbohydr. Polym."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2304","DOI":"10.3762\/bjnano.10.222","article-title":"Design of a nanostructured mucoadhesive system containing curcumin for buccal application: From physicochemical to biological aspects","volume":"10","author":"Ferreira","year":"2019","journal-title":"Beilstein J. Nanotechnol."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"153","DOI":"10.1007\/s10856-015-5493-4","article-title":"Pluronic F-127 hydrogel as a promising scaffold for encapsulation of dental-derived mesenchymal stem cells","volume":"26","author":"Diniz","year":"2015","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"1857","DOI":"10.1080\/03639045.2018.1504059","article-title":"Formulation and in vitro evaluation of a thermoreversible mucoadhesive nasal gel of itopride hydrochloride","volume":"44","author":"Marzouk","year":"2018","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"115","DOI":"10.1016\/j.ejps.2007.06.004","article-title":"Effect of hydroxypropyl beta-cyclodextrin on the self-assembling and thermogelation properties of Poloxamer 407","volume":"32","author":"Bonacucina","year":"2007","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"46","DOI":"10.1016\/j.chemphyslip.2018.05.008","article-title":"On the prediction of critical micelle concentration for sugar-based non-ionic surfactants","volume":"214","author":"Baghban","year":"2018","journal-title":"Chem. Phys. Lipids"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"2175","DOI":"10.1021\/acs.langmuir.6b00039","article-title":"Temperature Effect on Micelle Formation: Molecular Thermodynamic Model Revisited","volume":"32","author":"Khoshnood","year":"2016","journal-title":"Langmuir"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"426","DOI":"10.1016\/j.colsurfb.2019.05.016","article-title":"Poloxamer-407 thickened lipid colloidal system of agomelatine for brain targeting: Characterization, brain pharmacokinetic study and behavioral study on Wistar rats","volume":"181","author":"Ahmed","year":"2019","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"2414","DOI":"10.1021\/ma00087a009","article-title":"Micellization of Poly(ethylene oxide)-Poly(propylene oxide)-Poly(ethylene oxide) Triblock Copolymers in Aqueous Solutions: Thermodynamics of Copolymer Association","volume":"27","author":"Alexandridis","year":"1994","journal-title":"Macromolecules"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"317","DOI":"10.1016\/j.ijpharm.2010.05.042","article-title":"Rheological characterization and in vivo evaluation of thermosensitive poloxamer-based hydrogel for intramuscular injection of piroxicam","volume":"395","author":"Xuan","year":"2010","journal-title":"Int. J. Pharm."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"278","DOI":"10.3109\/10837450.2013.775158","article-title":"Assessment of release kinetics, stability and polymer interaction of poloxamer 407-based thermosensitive gel of interleukin-1 receptor antagonist","volume":"19","author":"Akash","year":"2014","journal-title":"Pharm. Dev. Technol."},{"key":"ref_27","doi-asserted-by":"crossref","unstructured":"Cristiano, M.C., Froiio, F., Mancuso, A., De Gaetano, F., Ventura, C.A., Fresta, M., and Paolino, D. (2020). The Rheolaser Master\u2122 and Kinexus Rotational Rheometer(\u00ae) to Evaluate the Influence of Topical Drug Delivery Systems on Rheological Features of Topical Poloxamer Gel. Molecules, 25.","DOI":"10.3390\/molecules25081979"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"e00390","DOI":"10.1016\/j.heliyon.2017.e00390","article-title":"Thermogelling properties of purified poloxamer 407","volume":"3","author":"Fakhari","year":"2017","journal-title":"Heliyon"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"254","DOI":"10.1016\/j.jconrel.2014.03.052","article-title":"Hydrogels in a historical perspective: From simple networks to smart materials","volume":"190","author":"Buwalda","year":"2014","journal-title":"J. Control. Release"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Sosa, L., Calpena, A.C., Silva-Abreu, M., Espinoza, L.C., Rinc\u00f3n, M., Bozal, N., Domenech, O., Rodr\u00edguez-Lagunas, M.J., and Clares, B. (2019). Thermoreversible Gel-Loaded Amphotericin B for the Treatment of Dermal and Vaginal Candidiasis. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070312"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"303","DOI":"10.1016\/j.ejpb.2007.03.022","article-title":"Poly(ethylene oxide)-poly(propylene oxide) block copolymer micelles as drug delivery agents: Improved hydrosolubility, stability and bioavailability of drugs","volume":"66","author":"Chiappetta","year":"2007","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/0927-7757(94)03028-X","article-title":"Poly(ethylene oxide)-poly(propylene oxide )-poly (ethylene oxide) block copolymer surfactants in aqueous solutions and at interfaces: Thermodynamics, structure, dynamics, and modeling","volume":"96","author":"Alexandridis","year":"1995","journal-title":"Colloids Surf. A Physicochem. Eng. Asp."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"1600266","DOI":"10.1002\/mame.201600266","article-title":"Bioprinting of Thermoresponsive Hydrogels for Next Generation Tissue Engineering: A Review","volume":"302","author":"Suntornnond","year":"2017","journal-title":"Macromol. Mater. Eng."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"355","DOI":"10.1177\/0022034518810213","article-title":"A Novel Thermoresponsive Gel as a Potential Delivery System for Lipoxin","volume":"98","author":"Wang","year":"2019","journal-title":"J. Dent. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.biomaterials.2018.03.044","article-title":"Heparin-Poloxamer Thermosensitive Hydrogel Loaded with bFGF and NGF Enhances Peripheral Nerve Regeneration in Diabetic Rats","volume":"168","author":"Li","year":"2018","journal-title":"Biomaterials"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"338","DOI":"10.1208\/s12249-017-0839-5","article-title":"Thermosensitive In Situ Gel Based on Solid Dispersion for Rectal Delivery of Ibuprofen","volume":"19","author":"Liu","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.jobcr.2017.12.005","article-title":"Periodontal thermoresponsive, mucoadhesive dual antimicrobial loaded in-situ gel for the treatment of periodontal disease: Preparation, in-vitro characterization and antimicrobial study","volume":"8","author":"Bansal","year":"2018","journal-title":"J. Oral Biol. Craniofac. Res."},{"key":"ref_38","first-page":"100016","article-title":"In vitro evaluation of poloxamer in situ forming gels for bedaquiline fumarate salt and pharmacokinetics following intramuscular injection in rats","volume":"1","author":"Hemelryck","year":"2019","journal-title":"Int. J. Pharm. X"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"313","DOI":"10.3109\/08982104.2015.1132232","article-title":"Poloxamer 407-based intranasal thermoreversible gel of zolmitriptan-loaded nanoethosomes: Formulation, optimization, evaluation and permeation studies","volume":"26","author":"Shelke","year":"2016","journal-title":"J. Liposome Res."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"33","DOI":"10.1016\/S0378-5173(97)00386-4","article-title":"Development of in situ-gelling and mucoadhesive acetaminophen liquid suppository","volume":"165","author":"Choi","year":"1998","journal-title":"Int. J. Pharm."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"627","DOI":"10.3109\/10837450.2010.508074","article-title":"Rheological and mechanical properties of poloxamer mixtures as a mucoadhesive gel base","volume":"16","author":"Baloglu","year":"2011","journal-title":"Pharm. Dev. Technol."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1016\/j.ejps.2013.03.002","article-title":"Thermoreversible in situ gelling poloxamer-based systems with chitosan nanocomplexes for prolonged subcutaneous delivery of heparin: Design and in vitro evaluation","volume":"50","author":"Grabnar","year":"2013","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"1157","DOI":"10.2147\/OPTH.S208256","article-title":"Efficacy of carbomer sodium hyaluronate trehalose vs hyaluronic acid to improve tear film instability and ocular surface discomfort after cataract surgery","volume":"13","author":"Caretti","year":"2019","journal-title":"Clin. Ophthalmol."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"9","DOI":"10.1167\/tvst.7.3.9","article-title":"Subconjunctival Exposure to Carbopol Causes Chronic Histiocytic Inflammatory Response in Rabbits","volume":"7","author":"Dalvin","year":"2018","journal-title":"Transl. Vis. Sci. Technol."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"191","DOI":"10.1007\/s40268-019-0270-3","article-title":"Safety and Efficacy of 0.5% Carbomer 980 Gel for Treatment of Symptoms of Common Cold: Results of 2 Randomized Trials","volume":"19","author":"Dennie","year":"2019","journal-title":"Drugs R D"},{"key":"ref_46","doi-asserted-by":"crossref","first-page":"12415","DOI":"10.3390\/molecules181012415","article-title":"Mechanical, rheological and release behaviors of a poloxamer 407\/ poloxamer 188\/carbopol 940 thermosensitive composite hydrogel","volume":"18","author":"Chen","year":"2013","journal-title":"Molecules"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"29","DOI":"10.4103\/2230-973X.108961","article-title":"Formulation and evaluation of periodontal in situ gel","volume":"3","author":"Garala","year":"2013","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_48","first-page":"78","article-title":"Hyaluronic Acid in Inflammation and Tissue Regeneration","volume":"28","author":"Litwiniuk","year":"2016","journal-title":"Wounds"},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"522","DOI":"10.1590\/S0080-623420160000400020","article-title":"Hyaluronic acid covers in burn treatment: A systematic review","volume":"50","author":"Dalmedico","year":"2016","journal-title":"Rev. Esc. Enferm. USP"},{"key":"ref_50","doi-asserted-by":"crossref","first-page":"186","DOI":"10.22203\/eCM.v037a12","article-title":"Advances of hyaluronic acid in stem cell therapy and tissue engineering, including current clinical trials","volume":"37","author":"Antic","year":"2019","journal-title":"Eur. Cell Mater."},{"key":"ref_51","first-page":"71","article-title":"Hyaluronic acid-based scaffolds for tissue engineering","volume":"59","author":"Chircov","year":"2018","journal-title":"Rom. J. Morphol. Embryol."},{"key":"ref_52","doi-asserted-by":"crossref","first-page":"1834","DOI":"10.3889\/oamjms.2019.478","article-title":"Assessment of Hyaluronic Acid Gel Injection in the Reconstruction of Interdental Papilla: A Randomized Clinical Trial","volume":"7","author":"Abdelraouf","year":"2019","journal-title":"Open Access Maced. J. Med. Sci."},{"key":"ref_53","doi-asserted-by":"crossref","first-page":"153","DOI":"10.2147\/CIA.S2135","article-title":"Hyaluronic acid gel fillers in the management of facial aging","volume":"3","author":"Brandt","year":"2008","journal-title":"Clin. Interv. Aging"},{"key":"ref_54","first-page":"13","article-title":"Hyaluronic acid accelerates bone repair in human dental sockets: A randomized triple-blind clinical trial","volume":"32","author":"Castro","year":"2018","journal-title":"Braz. Oral Res."},{"key":"ref_55","doi-asserted-by":"crossref","unstructured":"Hsieh, H.Y., Lin, W.Y., Lee, A.L., Li, Y.C., Chen, Y.J., Chen, K.C., and Young, T.H. (2020). Hyaluronic acid on the urokinase sustained release with a hydrogel system composed of poloxamer 407: HA\/P407 hydrogel system for drug delivery. PLoS ONE, 15.","DOI":"10.1371\/journal.pone.0227784"},{"key":"ref_56","doi-asserted-by":"crossref","unstructured":"Kim, K., Choi, H., Choi, E.S., Park, M.H., and Ryu, J.H. (2019). Hyaluronic Acid-Coated Nanomedicine for Targeted Cancer Therapy. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11070301"},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"53","DOI":"10.18433\/J3K89D","article-title":"Hyaluronic acid and wound healing","volume":"18","author":"Neuman","year":"2015","journal-title":"J. Pharm. Pharm. Sci."},{"key":"ref_58","doi-asserted-by":"crossref","first-page":"107","DOI":"10.1002\/ame2.12067","article-title":"Effect of the hyaluronic acid-poloxamer hydrogel on skin-wound healing: In vitro and in vivo studies","volume":"2","author":"Li","year":"2019","journal-title":"Anim. Model. Exp. Med."},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Lima, L.C.B., Coelho, C.C., Silva, F.C., Meneguin, A.B., Barud, H.S., Bezerra, R.D.S., Viseras, C., Osajima, J.A., and Silva-Filho, E.C. (2019). Hybrid Systems Based on Talc and Chitosan for Controlled Drug Release. Materials, 12.","DOI":"10.3390\/ma12213634"},{"key":"ref_60","doi-asserted-by":"crossref","unstructured":"Aguilar, A., Zein, N., Harmouch, E., Hafdi, B., Bornert, F., Offner, D., Clauss, F., Fioretti, F., Huck, O., and Benkirane-Jessel, N. (2019). Application of Chitosan in Bone and Dental Engineering. Molecules, 24.","DOI":"10.3390\/molecules24163009"},{"key":"ref_61","doi-asserted-by":"crossref","unstructured":"Hu, Z., Zhang, D.Y., Lu, S.T., Li, P.W., and Li, S.D. (2018). Chitosan-Based Composite Materials for Prospective Hemostatic Applications. Mar. Drugs, 16.","DOI":"10.3390\/md16080273"},{"key":"ref_62","first-page":"1442","article-title":"Chitosan temperature-sensitive gel loaded with drug microspheres has excellent effectiveness, biocompatibility and safety as an ophthalmic drug delivery system","volume":"15","author":"Kong","year":"2018","journal-title":"Exp. Ther. Med."},{"key":"ref_63","first-page":"e696","article-title":"The effects of a topical gel containing chitosan, 0,2% chlorhexidine, allantoin and despanthenol on the wound healing process subsequent to impacted lower third molar extraction","volume":"21","year":"2016","journal-title":"Med. Oral Patol. Oral Cir. Bucal"},{"key":"ref_64","doi-asserted-by":"crossref","first-page":"116268","DOI":"10.1016\/j.carbpol.2020.116268","article-title":"Thermoresponsive systems composed of poloxamer 407 and HPMC or NaCMC: Mechanical, rheological and sol-gel transition analysis","volume":"240","author":"Cook","year":"2020","journal-title":"Carbohydr. Polym."},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"114","DOI":"10.1016\/j.ijpharm.2012.03.054","article-title":"Thermosensitive and mucoadhesive in situ gel based on poloxamer as new carrier for rectal administration of nimesulide","volume":"430","author":"Yuan","year":"2012","journal-title":"Int. J. Pharm."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"63","DOI":"10.1080\/03639040500390934","article-title":"Development of a thermogelling ophthalmic formulation of cysteine","volume":"32","author":"Dumortier","year":"2006","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"495","DOI":"10.1080\/17425247.2020.1731469","article-title":"Formulation strategies to modulate drug release from poloxamer based in situ gelling systems","volume":"17","author":"Abdeltawab","year":"2020","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_68","doi-asserted-by":"crossref","unstructured":"Bodratti, A.M., and Alexandridis, P. (2018). Formulation of Poloxamers for Drug Delivery. J. Funct. Biomater., 9.","DOI":"10.3390\/jfb9010011"},{"key":"ref_69","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1016\/j.msec.2016.05.088","article-title":"Poloxamer 407\/188 binary thermosensitive hydrogels as delivery systems for infiltrative local anesthesia: Physico-chemical characterization and pharmacological evaluation","volume":"68","author":"Akkari","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"1245","DOI":"10.1016\/j.ijbiomac.2018.01.064","article-title":"Hyaluronic acid in Pluronic F-127\/F-108 hydrogels for postoperative pain in arthroplasties: Influence on physico-chemical properties and structural requirements for sustained drug-release","volume":"111","author":"Nascimento","year":"2018","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.ejpb.2017.01.008","article-title":"Poloxamer-based thermoresponsive ketorolac tromethamine in situ gel preparations: Design, characterisation, toxicity and transcorneal permeation studies","volume":"114","author":"Fathalla","year":"2017","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"225","DOI":"10.1016\/j.ejpb.2010.11.022","article-title":"Thermosensitive hydrogels for nasal drug delivery: The formulation and characterisation of systems based on N-trimethyl chitosan chloride","volume":"77","author":"Nazar","year":"2011","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_73","doi-asserted-by":"crossref","first-page":"306","DOI":"10.1016\/j.ejps.2009.02.022","article-title":"Effect of carrageenan on poloxamer-based in situ gel for vaginal use: Improved in vitro and in vivo sustained-release properties","volume":"37","author":"Liu","year":"2009","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"375","DOI":"10.3109\/10717544.2014.891272","article-title":"Poloxamer-based in situ hydrogels for controlled delivery of hydrophilic macromolecules after intramuscular injection in rats","volume":"22","author":"Zhang","year":"2015","journal-title":"Drug Deliv."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"186","DOI":"10.1016\/j.ejpb.2010.02.011","article-title":"A poloxamer\/chitosan in situ forming gel with prolonged retention time for ocular delivery","volume":"75","author":"Gratieri","year":"2010","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_76","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.ijpharm.2015.12.070","article-title":"Fabrication of pluronic and methylcellulose for etidronate delivery and their application for osteogenesis","volume":"499","author":"Rangabhatla","year":"2016","journal-title":"Int. J. Pharm."},{"key":"ref_77","doi-asserted-by":"crossref","first-page":"150","DOI":"10.1080\/1061186X.2017.1350858","article-title":"Brain targeted delivery of mucoadhesive thermosensitive nasal gel of selegiline hydrochloride for treatment of Parkinson\u2019s disease","volume":"26","author":"Sridhar","year":"2018","journal-title":"J. Drug Target."},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"845","DOI":"10.1016\/j.jsps.2018.03.014","article-title":"Novel in-situ gel for intravesical administration of ketorolac","volume":"26","author":"Sherif","year":"2018","journal-title":"Saudi Pharm. J."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"24","DOI":"10.1016\/j.ejps.2015.05.014","article-title":"Novel thermosensitive in situ gel based on poloxamer for uterus delivery","volume":"77","author":"Lu","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_80","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/S0378-5173(99)00225-2","article-title":"Effect of additives on the physicochemical properties of liquid suppository bases","volume":"190","author":"Choi","year":"1999","journal-title":"Int. J. Pharm."},{"key":"ref_81","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1038\/nri2294","article-title":"Resolving inflammation: Dual anti-inflammatory and pro-resolution lipid mediators","volume":"8","author":"Serhan","year":"2008","journal-title":"Nat. Rev. Immunol."},{"key":"ref_82","doi-asserted-by":"crossref","first-page":"E162","DOI":"10.1208\/pt070376","article-title":"Development of tetracycline-serratiopeptidase-containing periodontal gel: Formulation and preliminary clinical study","volume":"7","author":"Maheshwari","year":"2006","journal-title":"AAPS PharmSciTech"},{"key":"ref_83","doi-asserted-by":"crossref","first-page":"705","DOI":"10.1002\/alr.21944","article-title":"Intranasal distribution and clearance of thermoreversible gel in an animal model","volume":"7","author":"Choi","year":"2017","journal-title":"Int. Forum Allergy Rhinol."},{"key":"ref_84","doi-asserted-by":"crossref","first-page":"133","DOI":"10.1080\/10717544.2016.1233591","article-title":"Formulation, in-vitro characterization and clinical evaluation of curcumin in-situ gel for treatment of periodontitis","volume":"24","author":"Nasra","year":"2017","journal-title":"Drug Deliv."},{"key":"ref_85","doi-asserted-by":"crossref","first-page":"74","DOI":"10.2174\/156720112798375998","article-title":"Dual controlled release, in situ gelling periodontal sol of metronidazole benzoate and serratiopeptidase: Statistical optimization and mechanistic evaluation","volume":"9","author":"Kumari","year":"2012","journal-title":"Curr. Drug Deliv."},{"key":"ref_86","doi-asserted-by":"crossref","first-page":"1506","DOI":"10.1016\/j.msec.2017.03.054","article-title":"Formulation of thermoreversible gel of cranberry juice concentrate: Evaluation, biocompatibility studies and its antimicrobial activity against periodontal pathogens","volume":"75","author":"Rajeshwari","year":"2017","journal-title":"Mater. Sci Eng. C Mater. Biol. Appl."},{"key":"ref_87","first-page":"1635","article-title":"Human herpes simplex virus: Life cycle and development of inhibitors","volume":"79","author":"Kukhanova","year":"2014","journal-title":"Biochemistry"},{"key":"ref_88","first-page":"1704","article-title":"Herpes labialis","volume":"23","author":"Worrall","year":"2009","journal-title":"BMJ Clin. Evid."},{"key":"ref_89","doi-asserted-by":"crossref","first-page":"897","DOI":"10.1093\/infdis\/138.6.897","article-title":"The natural history of recurrent facial-oral infection with herpes simplex virus","volume":"138","author":"Bader","year":"1978","journal-title":"J. Infect. Dis."},{"key":"ref_90","first-page":"280928","article-title":"Preparation and evaluation of novel in situ gels containing acyclovir for the treatment of oral herpes simplex virus infections","volume":"24","author":"Chaudhary","year":"2014","journal-title":"Sci. World J."},{"key":"ref_91","doi-asserted-by":"crossref","first-page":"13","DOI":"10.1016\/j.coms.2018.08.002","article-title":"Oral Cavity Cancer","volume":"31","author":"Ettinger","year":"2019","journal-title":"Oral Maxillofac Surg. Clin. N. Am."},{"key":"ref_92","doi-asserted-by":"crossref","first-page":"1582","DOI":"10.1038\/bjc.2011.403","article-title":"Development of tissue-engineered models of oral dysplasia and early invasive oral squamous cell carcinoma","volume":"105","author":"Colley","year":"2011","journal-title":"Br. J. Cancer"},{"key":"ref_93","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.ijpharm.2014.04.039","article-title":"Transdermal delivery of the in situ hydrogels of curcumin and its inclusion complexes of hydroxypropyl-\u03b2-cyclodextrin for melanoma treatment","volume":"469","author":"Sun","year":"2014","journal-title":"Int. J. Pharm."},{"key":"ref_94","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.colsurfb.2012.04.017","article-title":"Curcumin loaded mixed micelles composed of Pluronic P123 and F68: Preparation, optimization and in vitro characterization","volume":"97","author":"Zhao","year":"2012","journal-title":"Colloids Surf. B Biointerfaces"},{"key":"ref_95","doi-asserted-by":"crossref","first-page":"963","DOI":"10.1021\/mp100094k","article-title":"Thermoresponsive hydrogel as a delivery scaffold for transfected rat mesenchymal stem cells","volume":"7","author":"Borden","year":"2010","journal-title":"Mol. Pharm."},{"key":"ref_96","first-page":"363","article-title":"Osteoblastic differentiation of rabbit mesenchymal stem cells loaded in A carrier system of Pluronic F127 and Interpore","volume":"29","author":"Huang","year":"2006","journal-title":"Chang Gung Med. J."},{"key":"ref_97","doi-asserted-by":"crossref","first-page":"80","DOI":"10.1016\/j.biomaterials.2011.09.041","article-title":"Enhancement of mesenchymal stem cell angiogenic capacity and stemness by a biomimetic hydrogel scaffold","volume":"33","author":"Rustad","year":"2012","journal-title":"Biomaterials"}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/16\/4522\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:44:33Z","timestamp":1760165073000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/16\/4522"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,12]]},"references-count":97,"journal-issue":{"issue":"16","published-online":{"date-parts":[[2021,8]]}},"alternative-id":["ma14164522"],"URL":"https:\/\/doi.org\/10.3390\/ma14164522","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,12]]}}}