{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,8]],"date-time":"2026-10-08T21:43:35Z","timestamp":1791495815257,"version":"4.3.4"},"reference-count":96,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2021,8,27]],"date-time":"2021-08-27T00:00:00Z","timestamp":1630022400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100014269","name":"Uniwersytet Medyczny w Bia\u0142ymstoku","doi-asserted-by":"publisher","award":["SUB\/2\/DN\/21\/001\/2215"],"award-info":[{"award-number":["SUB\/2\/DN\/21\/001\/2215"]}],"id":[{"id":"10.13039\/501100014269","id-type":"DOI","asserted-by":"publisher"}]},{"name":"OP DEP 2007\u20132013, Priority Axis I.3","award":["POPW.01.03.00-20-008\/09"],"award-info":[{"award-number":["POPW.01.03.00-20-008\/09"]}]},{"name":"EU founds","award":["POPW.O1.03.00-20-004\/11"],"award-info":[{"award-number":["POPW.O1.03.00-20-004\/11"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Polymers constitute a group of materials having a wide-ranging impact on modern pharmaceutical technology. Polymeric components provide the foundation for the advancement of novel drug delivery platforms, inter alia orodispersible films. Orodispersible films are thin, polymeric scraps intended to dissolve quickly when put on the tongue, allowing them to be easily swallowed without the necessity of drinking water, thus eliminating the risk of choking, which is of great importance in the case of pediatric and geriatric patients. Polymers are essential excipients in designing orodispersible films, as they constitute the backbone of these drug dosage form. The type of polymer is of significant importance in obtaining the formulation of the desired quality. The polymers employed to produce orodispersible films must meet particular requirements due to their oral administration and have to provide adequate surface texture, film thickness, mechanical attributes, tensile and folding strength as well as relevant disintegration time and drug release to obtain the final product characterized by optimal pharmaceutical features. A variety of natural and synthetic polymers currently utilized in manufacturing of orodispersible films might be used alone or in a blend. The goal of the present manuscript was to present a review about polymers utilized in designing oral-dissolving films.<\/jats:p>","DOI":"10.3390\/ma14174872","type":"journal-article","created":{"date-parts":[[2021,8,30]],"date-time":"2021-08-30T22:49:51Z","timestamp":1630363791000},"page":"4872","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":47,"title":["\u201cSuccess Depends on Your Backbone\u201d\u2014About the Use of Polymers as Essential Materials Forming Orodispersible Films"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5333-7016","authenticated-orcid":false,"given":"Katarzyna","family":"Olechno","sequence":"first","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2331-1779","authenticated-orcid":false,"given":"Anna","family":"Basa","sequence":"additional","affiliation":[{"name":"Department of Physical Chemistry, Faculty of Chemistry, University of Bialystok, Ciolkowskiego 1K, 15-245 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1013-610X","authenticated-orcid":false,"given":"Katarzyna","family":"Winnicka","sequence":"additional","affiliation":[{"name":"Department of Pharmaceutical Technology, Medical University of Bialystok, Mickiewicza 2c, 15-222 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,8,27]]},"reference":[{"key":"ref_1","unstructured":"(2021, March 10). Routes of Administration of Drug Dosage Forms According to FDA, Available online: https:\/\/www.fda.gov\/drugs\/data-standards-manual-monographs\/route-administration."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"261","DOI":"10.1016\/j.ijpharm.2015.06.047","article-title":"Methods of administering oral formulations and child acceptability","volume":"491","author":"Ferreira","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"234","DOI":"10.1208\/s12249-015-0313-1","article-title":"Orally disintegrating films and mini-tablets\u2014Innovative dosage forms of choice for pediatric use","volume":"16","author":"Preis","year":"2015","journal-title":"AAPS PharmSciTech"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"137","DOI":"10.1080\/10837450.2017.1281543","article-title":"Oral dosage forms and drug delivery systems: Tablets, oral films, liquid dosage forms, oral bioavailability enhancement","volume":"22","author":"Alany","year":"2017","journal-title":"Pharm. Dev. Technol."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"299","DOI":"10.1517\/17425247.2011.553217","article-title":"Advances in orodispersible films for drug delivery","volume":"8","author":"Hoffmann","year":"2011","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"111","DOI":"10.3329\/icpj.v5i12.30413","article-title":"Oral films: A comprehensive review","volume":"5","author":"Mahboob","year":"2016","journal-title":"Int. Cur. Pharm. J."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2015.03.006","article-title":"Oral films: Current status and future perspectives I\u2014Galenical development and quality attributes","volume":"206","author":"Borges","year":"2015","journal-title":"J. Control. Release"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"251","DOI":"10.1016\/j.drudis.2017.10.003","article-title":"Orodispersible dosage forms: Biopharmaceutical improvements and regulatory requirements","volume":"23","author":"Cilurzo","year":"2018","journal-title":"Drug Discov. Today"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"537","DOI":"10.1016\/j.jsps.2015.02.024","article-title":"Orally disintegrating films: A modern expansion in drug delivery system","volume":"24","author":"Irfan","year":"2016","journal-title":"Saudi Pharm. J."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"327","DOI":"10.1016\/j.ijpharm.2017.03.018","article-title":"Orodispersible films: Towards drug delivery in special populations","volume":"523","author":"Scarpa","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_11","unstructured":"(2019). The European Pharmacopoeia, Council of Europe. [10th ed.]."},{"key":"ref_12","unstructured":"FDA, and CDER (2021, April 15). Guidance for Industry\u2014Orally Disintegrating Tablets, Available online: https:\/\/www.fda.gov\/downloads\/Drugs\/Guidances\/ucm070578.pdf."},{"key":"ref_13","unstructured":"(2018). The United States Pharmacopeia and National Formulary (USP41-NF 36), Pharmacopeia Convention."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"895","DOI":"10.1016\/j.ejpb.2008.06.032","article-title":"Fast dissolving films made of maltodextrin","volume":"70","author":"Cilurzo","year":"2008","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_15","first-page":"33","article-title":"Exploration of different polymers for use in the formulation of oral fast dissolving strips","volume":"2","author":"Kulkarni","year":"2010","journal-title":"J. Cur. Pharm. Res."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"110","DOI":"10.3109\/03639045.2012.749889","article-title":"Effect of polymer, plasticizer and filler on orally disintegrating films","volume":"40","author":"Liew","year":"2014","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_17","first-page":"1533","article-title":"Formulation and characterization of loratadine containing orodispersible lyophilizates and films","volume":"74","author":"Amelian","year":"2017","journal-title":"Acta Pol. Pharm. Drug Res."},{"key":"ref_18","unstructured":"Rowe, R.C., Sheskey, P.J., and Quinn, M.E. (2009). Handbook of Pharmaceutical Excipients, Pharmaceutical Press. [6th ed.]."},{"key":"ref_19","first-page":"169","article-title":"Polymers used for fast disintegrating oral films: A review","volume":"21","author":"Pathare","year":"2013","journal-title":"Int. J. Pharm. Sci. Rev. Res."},{"key":"ref_20","unstructured":"Qui, Y., Zhang, G.G.Z., Mantri, R.V., Chen, Y., and Yu, L. (2017). Developing Solid Oral Dosage Forms. Pharmaceutical Theory and Practice, Academic Press. [2nd ed.]."},{"key":"ref_21","unstructured":"(2021, March 10). FDA Inactive Ingredients Database, Available online: https:\/\/search.fda.gov\/search?utf8=%E2%9C%93&affiliate=fda1&query=ethylcellulose&commit=Search."},{"key":"ref_22","unstructured":"(2021, March 10). Safety & Toxicity of Excipients for Paediatrics, STEP Database. Available online: http:\/\/www.eupfi.org\/step-database-info\/."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"695","DOI":"10.1016\/j.jconrel.2020.05.045","article-title":"Hypromellose\u2014A traditional pharmaceutical excipient with modern applications in oral and oromucosal drug delivery","volume":"324","author":"Vllasaliu","year":"2020","journal-title":"J. Control. Release"},{"key":"ref_24","unstructured":"(2021, April 21). Methocel. Available online: https:\/\/www.pharma.dupont.com\/\/pharmaceutical-brands\/methocel.html."},{"key":"ref_25","unstructured":"(2021, April 21). Pharmacoat, Metolose. Available online: https:\/\/www.metolose.jp\/en\/pharmaceutical\/."},{"key":"ref_26","unstructured":"(2021, April 21). Benecel. Available online: https:\/\/www.ashland.com\/industries\/pharmaceutical\/oral-solid-dose\/benecel-methylcellulose-and-hypromellose."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"171","DOI":"10.1016\/S0928-0987(99)00054-8","article-title":"Characterisation of particle properties and compaction behaviour of hydroxypropylmethylcellulose with different degrees of methoxy\/hydroxypropyl substitution","volume":"9","author":"Gustafsson","year":"1999","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_28","unstructured":"(2021, April 21). Affinisol. Available online: https:\/\/www.pharma.dupont.com\/pharmaceutical-brands\/affinisol.html."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"189","DOI":"10.1016\/j.ejpb.2004.06.008","article-title":"Characterization of cellulosic hot-melt extruded films containing lidocaine","volume":"59","author":"Repka","year":"2005","journal-title":"Eur. J. Pharm. Biopharm."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"21","DOI":"10.2174\/156720110790396454","article-title":"Development of taste masked fast disintegrating films of levocetirizine dihydrochloride for oral use","volume":"7","author":"Mahesh","year":"2010","journal-title":"Curr. Drug Deliv."},{"key":"ref_31","first-page":"318","article-title":"Development of taste masked film of valdecoxib for oral use","volume":"69","author":"Sharma","year":"2007","journal-title":"Indian J. Pharm. Sci."},{"key":"ref_32","doi-asserted-by":"crossref","unstructured":"Centkowska, K., \u0141awrecka, E., and Sznitowska, M. (2020). Technology of orodispersible polymer films with micronized loratadine\u2014influence of different drug loadings on film properties. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12030250"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"134","DOI":"10.1016\/j.ijpharm.2015.07.032","article-title":"Development of orodispersible polymer films containing poorly water soluble active pharmaceutical ingredients with focus on different drug loadings and storage stability","volume":"493","author":"Woertz","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_34","first-page":"4","article-title":"Development of zolmitriptan mouth dissolving films: Formulation variables, mechanical properties, and in vitro drug release studies","volume":"12","author":"Maddel","year":"2019","journal-title":"Asian J. Pharm. Clin. Res."},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1499","DOI":"10.1080\/17425247.2020.1828342","article-title":"Designing orodispersible films containing everolimus for enhanced compliance and bioavailability","volume":"17","author":"Ma","year":"2020","journal-title":"Expert Opin. Drug. Deliv."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"1751","DOI":"10.1080\/03639045.2019.1656733","article-title":"Effect of casting solvent, film-forming agent and solubilizer on orodispersible films of a polymorphic poorly soluble drug: An in vitro\/in silico study","volume":"45","year":"2019","journal-title":"Drug. Dev. Ind. Pharm."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.ejps.2015.04.006","article-title":"Orodispersible films and tablets with prednisolone microparticles","volume":"75","author":"Brniak","year":"2015","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_38","first-page":"242","article-title":"Orodispersible films based on amorphous solid dispersions of tetrabenazine","volume":"25","author":"Bourgeois","year":"2017","journal-title":"Int. J. Pharm."},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"582","DOI":"10.1111\/jphp.12627","article-title":"Formulation of orodspersible films for paediatric therapy: Investigation of feasibility and stability for tetrabenazine as drug model","volume":"69","author":"Bourgeois","year":"2017","journal-title":"J. Pharm. Pharmacol."},{"key":"ref_40","doi-asserted-by":"crossref","unstructured":"Panraksa, P., Udomsom, S., Rachtanapun, P., Chittasupho, C., Ruksiriwanich, W., and Jantrawut, P. (2020). Hydroxypropyl methylcellulose E15: A hydrophilic polymer for fabrication of orodispersible film using syringe extrusion 3D printer. Polymers, 12.","DOI":"10.3390\/polym12112666"},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"707","DOI":"10.1007\/s11094-017-1679-z","article-title":"Cellulose orodispersible films of donepezil: Film characterization and drug release","volume":"51","author":"Reddy","year":"2017","journal-title":"Pharm. Chem. J."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"183","DOI":"10.1016\/j.ejps.2017.07.010","article-title":"Increased drug load and polymer compatibility of bilayered orodispersible films","volume":"30","author":"Visser","year":"2017","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"349","DOI":"10.1208\/s12249-008-9047-7","article-title":"Formulation and evaluation of fast dissolving films for delivery of triclosan to the oral cavity","volume":"9","author":"Dinge","year":"2008","journal-title":"AAPS PharmSciTech"},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"724","DOI":"10.7897\/2230-8407.0610141","article-title":"Formulation and evaluation of fast dissolving films of granisetron hydrochloride","volume":"6","author":"Rathore","year":"2015","journal-title":"Int. Res. J. Pharm."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"2171","DOI":"10.1007\/s12272-012-1215-3","article-title":"Fast disintegrating films containing anastrazole as dosage form for dysphagia patients","volume":"35","author":"Dixit","year":"2012","journal-title":"Arch. Pharm. Res."},{"key":"ref_46","doi-asserted-by":"crossref","unstructured":"Tian, Y., Bhide, Y.C., Woerdenbag, H.J., Huckriede, A.L., Frijlink, H.W., Hinrichs, W.L.J., and Visser, J.C. (2020). Development of an orodispersible film containing stabilized influenza vaccine. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12030245"},{"key":"ref_47","doi-asserted-by":"crossref","first-page":"138","DOI":"10.1016\/j.ijpharm.2017.11.052","article-title":"QR encoded smart oral dosage forms by inject printing","volume":"536","author":"Edinger","year":"2018","journal-title":"Int. J. Pharm."},{"key":"ref_48","first-page":"183","article-title":"Development and pharmaceutical evaluation of oral fast dissolving thin film of escitalopram: A patient friendly dosage form","volume":"33","author":"Mushtaque","year":"2020","journal-title":"Pak. J. Pharm. Sci."},{"key":"ref_49","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1080\/03639045.2020.1734018","article-title":"Semi-solid extrusion 3D printing ODFs: An individual drug delivery system for small scale pharmacy","volume":"46","author":"Yan","year":"2020","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_50","doi-asserted-by":"crossref","unstructured":"Serrano, D.R., Fernandez-Garcia, R., Mele, M., Healy, A.M., and Lalatsa, A. (2019). Designing fast-dissolving orodispersible films of amphotericin B for oropharyngeal candidiasis. Pharmaceutics, 11.","DOI":"10.3390\/pharmaceutics11080369"},{"key":"ref_51","unstructured":"Mateescu, M.A., Ispas-Szabo, P., and Assaad, E. (2015). Starch and derivatives as pharmaceutical excipients: From nature to pharmacy. Controlled Drug Delivery. The Role of Self-Assembling Multitask Excipients, Woodhead Publishing. [1st ed.]."},{"key":"ref_52","doi-asserted-by":"crossref","unstructured":"Bertoft, E. (2017). Understanding starch structure: Recent progress. Agronomy, 7.","DOI":"10.3390\/agronomy7030056"},{"key":"ref_53","unstructured":"(2021, April 21). Lycoat. Available online: https:\/\/www.roquette.com\/pharma-and-nutraceuticals-hydroxypropyl-pea-starch-lycoat."},{"key":"ref_54","doi-asserted-by":"crossref","first-page":"204","DOI":"10.4172\/pharmaceutical-sciences.1000218","article-title":"Formulation and evaluation of orally disintegrating films of levocetirizine dihydrochloride","volume":"79","author":"Kathpalia","year":"2017","journal-title":"Ind. J. Pharm. Sci."},{"key":"ref_55","doi-asserted-by":"crossref","first-page":"325","DOI":"10.4103\/0975-7406.72133","article-title":"Fast dissolving strips: A novel approach for the delivery of verapamil","volume":"2","author":"Kunte","year":"2010","journal-title":"J. Pharm. Bioallied. Sci."},{"key":"ref_56","doi-asserted-by":"crossref","first-page":"280","DOI":"10.1016\/j.ijpharm.2019.01.046","article-title":"A new melatonin oral delivery platform based on orodispersible films containing solid lipid microparticles","volume":"559","author":"Musazzi","year":"2019","journal-title":"Int. J. Pharm."},{"key":"ref_57","doi-asserted-by":"crossref","first-page":"2509","DOI":"10.1208\/s12249-018-1088-y","article-title":"Development of orodispersible films containing benzydamine hydrochloride using modified solvent casting method","volume":"19","author":"Pechova","year":"2018","journal-title":"AAPS PharmSciTech"},{"key":"ref_58","doi-asserted-by":"crossref","unstructured":"Cupone, I.E., Dellera, E., Marra, F., and Giori, A.M. (2020). Development and characterization of an orodispersible film for vitamin D3 supplementation. Molecules, 25.","DOI":"10.3390\/molecules25245851"},{"key":"ref_59","doi-asserted-by":"crossref","unstructured":"Jaipakdeeb, N., and Limpongsaa, E. (2020). Physical modification of Thai rice starch and its application as orodispersible film former. Carbohydr. Polym., 239.","DOI":"10.1016\/j.carbpol.2020.116206"},{"key":"ref_60","first-page":"202","article-title":"An insight to pullulan: A biopolymer in pharmaceutical approaches","volume":"1","author":"Kumar","year":"2012","journal-title":"Int. J. Basic Appl. Sci."},{"key":"ref_61","first-page":"3358","article-title":"Polisaccharide-based nanomedicines for cancer immunotherapy: A review","volume":"6","author":"Zeng","year":"2021","journal-title":"Bioact. Mater."},{"key":"ref_62","doi-asserted-by":"crossref","unstructured":"Chachlioutaki, K., Tzimtzimis, E.K., Tzetzis, D., Chang, M.-W., Ahmad, Z., Karavasili, C., and Fatouros, D. (2020). Electrospun orodispersible film of isoniazid for pediatric tuberculosis treatment. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12050470"},{"key":"ref_63","doi-asserted-by":"crossref","first-page":"131","DOI":"10.1016\/j.cis.2018.11.008","article-title":"Pharmaceutical applications of chitosan","volume":"263","author":"Shariatinia","year":"2019","journal-title":"Adv. Colloid Interface Sci."},{"key":"ref_64","first-page":"327","article-title":"Preparation, characterization and in vitro evaluation of a polyvinyl alcohol\/sodium alginate based orodispersible film containing sildenafil citrate","volume":"69","author":"Shia","year":"2014","journal-title":"Pharmazie"},{"key":"ref_65","doi-asserted-by":"crossref","first-page":"201","DOI":"10.4103\/2230-973X.195927","article-title":"Formulation development and evaluation of zolmitriptan oral soluble films using 2 factorial design","volume":"6","author":"Koteswari","year":"2016","journal-title":"Int. J. Pharm. Investig."},{"key":"ref_66","doi-asserted-by":"crossref","first-page":"922","DOI":"10.1007\/s10924-020-01937-y","article-title":"In vitro and in vivo evaluation of oral disintegrating nanofiber and thin-film contains hyperbranched chitosan\/donepezil for active drug delivery","volume":"29","author":"Reddy","year":"2021","journal-title":"J. Pol. Envir."},{"key":"ref_67","doi-asserted-by":"crossref","first-page":"224","DOI":"10.1016\/j.ijbiomac.2019.06.224","article-title":"Fast dissolving oral films for drug delivery prepared from chitosan\/pullulan electrospinning nanofibers","volume":"137","author":"Qin","year":"2019","journal-title":"Int. J. Biol. Macromol."},{"key":"ref_68","doi-asserted-by":"crossref","first-page":"16","DOI":"10.1080\/14786419.2018.1552698","article-title":"Natural and semisynthetic polymers blended orodispersible films of citalopram","volume":"32","author":"Shahzad","year":"2020","journal-title":"Nat. Prod. Res."},{"key":"ref_69","doi-asserted-by":"crossref","unstructured":"Tosif, M.M., Najda, A., Bains, A., Kaushnik, R., Dhull, S.B., Chawla, P., and Walasek-Janusz, M. (2021). A comprehensive review on plant-derived mucilage: Characterization, functional properties, applications, and its utilization for nanocarrier fabrication. Polymers, 13.","DOI":"10.3390\/polym13071066"},{"key":"ref_70","doi-asserted-by":"crossref","first-page":"5","DOI":"10.4172\/2329-6631.1000112","article-title":"Polyvinyl alcohol in medicine and pharmacy: A perspective","volume":"2","author":"Muppalaneni","year":"2013","journal-title":"J. Develop. Drugs"},{"key":"ref_71","doi-asserted-by":"crossref","first-page":"25","DOI":"10.1081\/DDC-43947","article-title":"Development and evaluation of fast-dissolving film of salbutamol sulphate","volume":"31","author":"Mashru","year":"2005","journal-title":"Drug Dev. Ind. Pharm."},{"key":"ref_72","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1177\/0036850420964302","article-title":"Fabrication of polyvinyl alcohol based fast dissolving oral strips of sumatriptan succinate and metoclopramide HCL","volume":"103","author":"Zaman","year":"2020","journal-title":"Sci. Prog."},{"key":"ref_73","doi-asserted-by":"crossref","unstructured":"Panraksa, P., Tipduangta, P., Jantanasakulwong, K., and Jantrawut, P. (2020). Formulation of orally disintegrating films as an amorphous solid solution of a poorly water-soluble drug. Membranes, 10.","DOI":"10.3390\/membranes10120376"},{"key":"ref_74","doi-asserted-by":"crossref","first-page":"923","DOI":"10.1080\/03602559.2014.979506","article-title":"Poly(vinylpyrrolidone)\u2014A versatile polymer for biomedical and beyond medical applications","volume":"54","author":"Teodorescu","year":"2015","journal-title":"Polym. Plast. Technol. Eng."},{"key":"ref_75","doi-asserted-by":"crossref","first-page":"146","DOI":"10.1016\/j.ijpharm.2014.05.033","article-title":"Polyvinylpyrrolidone oral films of enrofloxacin: Film characterization and drug release","volume":"471","author":"Kumar","year":"2015","journal-title":"Int. J. Pharm."},{"key":"ref_76","first-page":"95","article-title":"Polyox (polyethylene oxide) multifunctional polymer in novel drug delivery system","volume":"6","author":"Shah","year":"2014","journal-title":"Int. J. Pharm. Sci. Drug Res."},{"key":"ref_77","doi-asserted-by":"crossref","unstructured":"Cho, H.-W., Baek, S.-H., Lee, B.-J., and Jin, H.-E. (2020). Orodispersible polymer films with the poorly water-soluble drug, olanzapine: Hit-melt pneumatic extrusion for single process 3D printing. Pharmaceutics, 12.","DOI":"10.3390\/pharmaceutics12080692"},{"key":"ref_78","doi-asserted-by":"crossref","first-page":"1357","DOI":"10.1080\/17425247.2016.1218458","article-title":"Hydrophobic polymers for orodispersible films: A quality by design approach","volume":"13","author":"Borges","year":"2016","journal-title":"Expert Opin. Drug Deliv."},{"key":"ref_79","doi-asserted-by":"crossref","first-page":"37","DOI":"10.1016\/j.ejps.2018.01.019","article-title":"Poly(methyl methacrylate) salt as film forming material to design orodispersible films","volume":"115","author":"Mussazi","year":"2018","journal-title":"Eur. J. Pharm. Sci."},{"key":"ref_80","unstructured":"(2021, March 10). Niquitin Mint Oral Strips. Available online: https:\/\/www.hpra.ie\/img\/uploaded\/swedocuments\/LicenseSPC_PA0678-071-018_27112015134038.pdf."},{"key":"ref_81","unstructured":"(2021, March 10). Benadryl Allergy Quick Dissolve Strip. Available online: https:\/\/www.drugs.com\/otc\/106077\/benadryl-allergy-quick-dissolve.htmL."},{"key":"ref_82","unstructured":"(2021, March 10). Chloraseptic Sore Throat Relief Strips. Available online: https:\/\/www.robertfreshmarket.com\/shop\/chloraseptic_sore_throat_relief_strips_cherry\/p\/2432811."},{"key":"ref_83","unstructured":"(2021, March 10). D-Fusion Film 800 UI. Available online: https:\/\/www.newpharma.de\/d-fusion\/824326\/d-fusion-film-balans-800-ui-ie-28.html."},{"key":"ref_84","unstructured":"(2021, March 10). Exservan Oral Film. Available online: https:\/\/www.rxlist.com\/exservan-drug.html."},{"key":"ref_85","unstructured":"(2021, March 10). Gas-X Thin Strips. Available online: https:\/\/www.walmart.com\/ip\/Gas-X-Thin-Strips-Extra-Strength-Peppermint-18-Each-Pack-of-3\/357662639."},{"key":"ref_86","unstructured":"(2021, March 10). IvyFilm, IvyFilm Kiddies. Available online: http:\/\/lamar.co.za\/sites\/default\/files\/files\/IvyFilm%20PIL%20L10024_14A_PROOF.pdf."},{"key":"ref_87","unstructured":"(2021, March 10). Listerine PocketPaks Oral Care Strips. Available online: https:\/\/www.listerine.com\/on-the-go-oral-health\/listerine-pocketpaks-cool-mint."},{"key":"ref_88","unstructured":"(2021, March 10). Pedia-Lax Quick Dissolve Strip. Available online: https:\/\/www.drugs.com\/sfx\/pedia."},{"key":"ref_89","unstructured":"(2021, March 10). Sudafed PE. Available online: https:\/\/www.webmd.com\/drugs\/2\/drug-144195\/sudafed-pe-quick-dissolve-oral\/details."},{"key":"ref_90","unstructured":"(2021, March 10). SildeHEXAL SF Orodispersible Film. Available online: https:\/\/downloads.dokteronline.com\/leaflets\/en\/patient_information_leaflet-2646-sildehexal-uk.pdf-1510756508.pdf."},{"key":"ref_91","unstructured":"(2021, March 10). Sildenafil IBSA Orodispersible Film. Available online: https:\/\/www.drugs.com\/uk\/sildenafil-ibsa-100-mg-orodispersible-film-leaflet.html."},{"key":"ref_92","unstructured":"(2021, March 10). Tusheel. Available online: https:\/\/www.heel.es\/es\/tusheel.html?logedin=5B4E1F806FDB5A5C1981C9D79191E9C0."},{"key":"ref_93","unstructured":"(2021, March 10). Setofilm Data. Available online: https:\/\/www.medicines.org.uk\/emc\/product\/9595\/smpc#gref."},{"key":"ref_94","unstructured":"(2021, March 10). Sympazan Oral Film. Available online: https:\/\/www.sympazan.com\/about-sympazan-clobazam.html."},{"key":"ref_95","unstructured":"(2021, March 10). Zentrip. Available online: https:\/\/www.drugs.com\/otc\/116987\/zentrip.html."},{"key":"ref_96","unstructured":"(2021, March 10). Zuplenz, Available online: https:\/\/www.accessdata.fda.gov\/drugsatfda_docs\/label\/2010\/022524s000lbl.pdf."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/17\/4872\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T06:53:18Z","timestamp":1760165598000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/17\/4872"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,8,27]]},"references-count":96,"journal-issue":{"issue":"17","published-online":{"date-parts":[[2021,9]]}},"alternative-id":["ma14174872"],"URL":"https:\/\/doi.org\/10.3390\/ma14174872","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,8,27]]}}}