{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,29]],"date-time":"2026-09-29T17:10:29Z","timestamp":1790701829371,"version":"4.1.0"},"reference-count":33,"publisher":"MDPI AG","issue":"20","license":[{"start":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T00:00:00Z","timestamp":1633910400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004543","name":"China Scholarship Council","doi-asserted-by":"publisher","award":["CSC202009110089"],"award-info":[{"award-number":["CSC202009110089"]}],"id":[{"id":"10.13039\/501100004543","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Government of Ireland","award":["GOIPD\/2019\/861"],"award-info":[{"award-number":["GOIPD\/2019\/861"]}]},{"DOI":"10.13039\/501100001588","name":"Enterprise Ireland","doi-asserted-by":"publisher","award":["DT20180247"],"award-info":[{"award-number":["DT20180247"]}],"id":[{"id":"10.13039\/501100001588","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["19\/FFP\/6522"],"award-info":[{"award-number":["19\/FFP\/6522"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Due to their biodegradability and biocompatibility, chitosan-based hydrogels have great potential in regenerative medicine, with applications such as bacteriostasis, hemostasis, and wound healing. However, toxicity and high cost are problems that must be solved for chitosan-based hydrogel crosslinking agents such as formaldehyde, glutaraldehyde, and genipin. Therefore, we developed a biocompatible yet cost-effective chitosan-based hydrogel system as a candidate biomaterial to prevent infection during wound healing. The hydrogel was fabricated by crosslinking chitosan with dialdehyde chitosan (CTS\u2013CHO) via dynamic Schiff-base reactions, resulting in a self-healable and injectable system. The rheological properties, degradation profile, and self-healable properties of the chitosan-based hydrogel were evaluated. The excellent antibacterial activity of the hydrogel was validated by a spread plate experiment. The use of Live\/Dead assay on HEK 293 cells showed that the hydrogel exhibited excellent biocompatibility. The results demonstrate that the newly designed chitosan-based hydrogel is an excellent antibacterial wound dressing candidate with good biocompatibility.<\/jats:p>","DOI":"10.3390\/ma14205956","type":"journal-article","created":{"date-parts":[[2021,10,11]],"date-time":"2021-10-11T21:45:32Z","timestamp":1633988732000},"page":"5956","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":95,"title":["An Injectable Chitosan-Based Self-Healable Hydrogel System as an Antibacterial Wound Dressing"],"prefix":"10.3390","volume":"14","author":[{"given":"Xiaoyu","family":"Wang","sequence":"first","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rijian","family":"Song","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Melissa","family":"Johnson","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Sigen","family":"A","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6533-4974","authenticated-orcid":false,"given":"Zhonglei","family":"He","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cameron","family":"Milne","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xianqing","family":"Wang","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9557-1388","authenticated-orcid":false,"given":"Irene","family":"Lara-S\u00e1ez","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Qian","family":"Xu","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5053-0611","authenticated-orcid":false,"given":"Wenxin","family":"Wang","sequence":"additional","affiliation":[{"name":"The Charles Institute of Dermatology, School of Medicine, University College Dublin, Dublin 4, Eircode D04 V1W8, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,10,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"137","DOI":"10.3389\/fbioe.2018.00137","article-title":"Borrowing From Nature: Biopolymers and Biocomposites as Smart Wound Care Materials","volume":"6","author":"Suarato","year":"2018","journal-title":"Front. 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