{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,21]],"date-time":"2026-10-21T14:15:13Z","timestamp":1792592113810,"version":"4.5.0"},"reference-count":37,"publisher":"MDPI AG","issue":"21","license":[{"start":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T00:00:00Z","timestamp":1636243200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001602","name":"Science Foundation Ireland","doi-asserted-by":"publisher","award":["20\/FFP-P\/8793"],"award-info":[{"award-number":["20\/FFP-P\/8793"]}],"id":[{"id":"10.13039\/501100001602","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006245","name":"Ministry of Science and Technology","doi-asserted-by":"publisher","award":["110-2113-M-027-003"],"award-info":[{"award-number":["110-2113-M-027-003"]}],"id":[{"id":"10.13039\/501100006245","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>In this study, we synthesized heterostructured zinc stannate\/tin oxide microparticles (ZTO\/TO MPs) by a simple coprecipitation method and used them as an effective electrode material for the electrochemical detection of the antibacterial drug secnidazole (SCZ). The as-prepared ZTO\/TO MPs were characterized by XRD, Raman, FE-SEM, HR-TEM, EDX, and XPS analyses. The physiochemical studies clearly proved that the fabricated ZTO\/TO MPs were formed in a heterostructure phase without other impurities. A glassy carbon electrode modified with the synthesized ZTO\/TO MPs showed an excellent and improved electrocatalytic activity in the electrochemical reduction of SCZ. Using differential pulse voltammetry (DPV), an impressive linear calibration range, extending from 0.01 to 193 \u03bcM, was observed, coupled with a detection limit of 0.0054 \u03bcM and a sensitivity of 0.055 \u03bcA\/\u03bcM. In addition, the ZTO\/TO MPs\/GCE showed very good selectivity for the detection of SCZ in the presence of a number of biological, inorganic, and structurally related compounds. Finally, the ZTO\/TO MPs\/GCE was investigated for the analysis of SCZ in human blood serum samples. A very good recovery was obtained when spiking the blood serum with SCZ, highlighting the good applicability of the ZTO\/TO MPs\/GCE for the electrochemical analysis of SCZ in complex biological samples.<\/jats:p>","DOI":"10.3390\/ma14216700","type":"journal-article","created":{"date-parts":[[2021,11,7]],"date-time":"2021-11-07T20:41:14Z","timestamp":1636317674000},"page":"6700","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":15,"title":["Fabrication of a Selective Sensor Amplification Probe Modified with Multi-Component Zn2SnO4\/SnO2 Heterostructured Microparticles as a Robust Electrocatalyst for Electrochemical Detection of Antibacterial Drug Secnidazole"],"prefix":"10.3390","volume":"14","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-9033-4201","authenticated-orcid":false,"given":"Ramaraj","family":"Sukanya","sequence":"first","affiliation":[{"name":"Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Karuppaiah","family":"Balamurugan","sequence":"additional","affiliation":[{"name":"Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0132-9161","authenticated-orcid":false,"given":"Shen-Ming","family":"Chen","sequence":"additional","affiliation":[{"name":"Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ramachandran","family":"Rajakumaran","sequence":"additional","affiliation":[{"name":"Electroanalysis and Bioelectrochemistry Lab, Department of Chemical Engineering and Biotechnology, National Taipei University of Technology, No. 1, Section 3, Chung-Hsiao East Road, Taipei 106, Taiwan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"K.","family":"Muthupandi","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Mannar Thirumalai Naicker College, Madurai 625004, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jae-Jin","family":"Shim","sequence":"additional","affiliation":[{"name":"School of Chemical Engineering, Yeungnam University, Gyeongsan 38541, Gyeongbuk, Korea"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0586-5375","authenticated-orcid":false,"given":"Carmel B.","family":"Breslin","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Maynooth University, W23F2H6 Maynooth, Co. Kildare, Ireland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,7]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"397","DOI":"10.1016\/j.molliq.2017.05.011","article-title":"Synthesis and characterization of bi-component ZnSnO3\/Zn2SnO4 (perovskite\/spinel) nano-composites for photocatalytic degradation of Intracron Blue: Structural, opto-electronic and morphology study","volume":"238","author":"Habibi","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"100410","DOI":"10.1016\/j.nanoso.2019.100410","article-title":"An efficient photocatalytic degradation of organic dyes under visible light using zinc stannate (Zn2SnO4) nanorods prepared by microwave irradiation","volume":"21","author":"Jain","year":"2020","journal-title":"Nano Struct. Nano Objects"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"124","DOI":"10.1016\/j.electacta.2018.01.026","article-title":"In situ growth of zinc oxide nanoribbons within the interstices of a zinc stannate nanoplates network on compacted woven metal wires and their enhanced solar energy application","volume":"262","author":"Li","year":"2018","journal-title":"Electrochim. Acta"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"31","DOI":"10.1016\/j.electacta.2019.04.167","article-title":"Enhanced electrochemical performance of hollow heterostructured carbon encapsulated znic metastanate microcube composite for lithium-ion and sodium-ion batteries","volume":"312","author":"Ma","year":"2019","journal-title":"Electrochim. Acta"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"514","DOI":"10.1016\/j.apsusc.2018.01.120","article-title":"Synthesis of highly crystalline octahedron 3D-Zn2SnO4 as an advanced high-performance anode material for lithium ion batteries","volume":"449","author":"Santhoshkumar","year":"2018","journal-title":"Appl. Surf. Sci."},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"197","DOI":"10.1016\/j.molliq.2017.10.055","article-title":"Metal (Mn, Co, Ni and Cu) doped ZnO-Zn2SnO4-SnO2 nanocomposites: Green sol-gel synthesis, characterization and photocatalytic activity","volume":"248","year":"2017","journal-title":"J. Mol. Liq."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.physb.2016.04.016","article-title":"Band gap tuning and room temperature ferromagnetism in Co doped Zinc stannate nanostructures","volume":"493","author":"Sumithra","year":"2016","journal-title":"Phys. B Condens. Matter"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"111834","DOI":"10.1016\/j.sna.2020.111834","article-title":"VOC gas sensor based on hollow cubic assembled nanocrystal Zn2SnO4 for breath analysis","volume":"302","author":"Hanh","year":"2020","journal-title":"Sens. Actuators A Phys."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"905","DOI":"10.1016\/j.ceramint.2017.10.021","article-title":"Flexible woven metal wires supported nanosheets and nanoparticles double-layered nitrogen-doped zinc stannate toward enhanced solar energy utilization","volume":"44","author":"Li","year":"2018","journal-title":"Ceram. Int."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"302","DOI":"10.1016\/j.snb.2018.03.121","article-title":"Enhanced gas sensing properties of monodisperse Zn2SnO4 octahedron functionalized by PdO nanoparticals","volume":"266","author":"Yang","year":"2018","journal-title":"Sens. Actuators B Chem."},{"key":"ref_11","doi-asserted-by":"crossref","unstructured":"Keles, E., Yildirim, M., \u00d6zt\u00fcrk, T., and Yildirim, O.A. (2020). Hydrothermally synthesized UV light active zinc stannate:tin oxide (ZTO:SnO2) nanocomposite photocatalysts for photocatalytic applications. Mater. Sci. Semicond. Process., 110.","DOI":"10.1016\/j.mssp.2020.104959"},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"765","DOI":"10.1016\/j.jallcom.2017.07.212","article-title":"Mechanism of wettability conversion on sprayed Zn2SnO4 thin films surfaces modified by thermal annealing in air","volume":"725","author":"Mrabet","year":"2017","journal-title":"J. Alloys Compd."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"144113","DOI":"10.1016\/j.apsusc.2019.144113","article-title":"Stainless steel mesh-supported three-dimensional hierarchical SnO2\/Zn2SnO4 composite for the applications in solar cell, gas sensor, and photocatalysis","volume":"502","author":"Li","year":"2020","journal-title":"Appl. Surf. Sci."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"103954","DOI":"10.1016\/j.nanoen.2019.103954","article-title":"Band alignment in Zn2SnO4\/SnO2 heterostructure enabling efficient CO2 electrochemical reduction","volume":"64","author":"Wang","year":"2019","journal-title":"Nano Energy"},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"154374","DOI":"10.1016\/j.jallcom.2020.154374","article-title":"Supersonically sprayed Zn2SnO4\/SnO2\/carbon nanotube films for high-efficiency water splitting photoanodes","volume":"828","author":"Kim","year":"2020","journal-title":"J. Alloys Compd."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"233","DOI":"10.21608\/ejchem.2010.1215","article-title":"Spectrophotometric determination of ornidazole, secnidazole and tinidazole in pharmaceutical preparations based on formation of dyes","volume":"53","author":"Khalile","year":"2010","journal-title":"Egypt. J. Chem."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"625","DOI":"10.1002\/elan.1140090809","article-title":"Electrochemical reduction of secnidazole and its determination in tablets","volume":"9","author":"Radi","year":"1997","journal-title":"Electroanalysis"},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1495","DOI":"10.1080\/03067319.2019.1622697","article-title":"A novel sensor based on multi-walled carbon nanotubes and boron-doped double-layer molecularly imprinted membrane for the analysis of SCZ in pharmaceutical and biological samples","volume":"99","author":"Peng","year":"2019","journal-title":"Int. J. Environ. Anal. Chem."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"843","DOI":"10.1016\/j.farmac.2004.06.001","article-title":"Spectrophotometric determination of metronidazole and secnidazole in pharmaceutical preparations","volume":"59","author":"Saffaj","year":"2004","journal-title":"Farmaco"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"304","DOI":"10.1002\/bmc.758","article-title":"Determination of secnidazole in human plasma by high-performance liquid chromatography with UV detection and its application to the bioequivalence studies","volume":"21","author":"Li","year":"2007","journal-title":"Biomed. Chromatogr."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"325","DOI":"10.1016\/S0378-4347(00)83346-0","article-title":"Electron-capture gas chromatographic assays of 5-nitroimidazole class of antimicrobials in blood","volume":"305","author":"Bhatia","year":"1984","journal-title":"J. Chromatogr. B Biomed. Sci. Appl."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"1634","DOI":"10.1080\/00032719.2014.883522","article-title":"Selective determination of fourteen nitroimidazoles in honey by high-performance liquid chromatography-tandem mass spectrometry","volume":"47","author":"Mitrowska","year":"2014","journal-title":"Anal. Lett."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"167","DOI":"10.1016\/j.arabjc.2010.04.005","article-title":"Determination of secnidazole in tablets and human serum by cathodic adsorptive stripping voltammetry","volume":"3","author":"Yasin","year":"2010","journal-title":"Arab. J. Chem."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"178","DOI":"10.1016\/j.matlet.2019.07.065","article-title":"Highly sensitive formaldehyde gas sensors based on Ag doped Zn2SnO4\/SnO2 hollow nanospheres","volume":"254","author":"Zhang","year":"2019","journal-title":"Mater. Lett."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"6273","DOI":"10.1016\/j.ceramint.2016.01.010","article-title":"Microstructural and optical properties of SnO2-ZnSnO3 ceramics","volume":"42","author":"Saafi","year":"2016","journal-title":"Ceram. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"2016","DOI":"10.1016\/j.ceramint.2019.09.181","article-title":"Nanoparticles of zinc stannates (ZTO): Synthesis, characterization and electrical behavior in oxygen and acetone vapors","volume":"46","author":"Montenegro","year":"2020","journal-title":"Ceram. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1016\/j.tsf.2015.04.065","article-title":"Alimuddin Annealed SnO2 thin films: Structural, electrical and their magnetic properties","volume":"589","author":"Mehraj","year":"2015","journal-title":"Thin Solid Films"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"67210","DOI":"10.1039\/C5RA06351E","article-title":"In situ and ex situ carbon coated Zn2SnO4 nanoparticles as promising negative electrodes for Li-ion batteries","volume":"5","author":"Yuvaraj","year":"2015","journal-title":"RSC Adv."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"12158","DOI":"10.1039\/C6TA04726B","article-title":"Reduced graphene oxide (rGO) grafted zinc stannate (Zn2SnO4) nanofiber scaffolds for highly efficient mixed-halide perovskite solar cells","volume":"4","author":"Mali","year":"2016","journal-title":"J. Mater. Chem. A"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"13212","DOI":"10.1109\/JSEN.2020.3005352","article-title":"One pot hydrothermal synthesis of large area nano cube like ZnSnO3 perovskite for simultaneous sensing of uric acid and dopamine using differential pulse voltammetry","volume":"20","author":"Durai","year":"2020","journal-title":"IEEE Sens. J."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.apcatb.2018.02.061","article-title":"Rational design and fabrication of multifunctional catalyzer Co2SnO4-SnO2\/GC for catalysis applications: Photocatalytic degradation\/catalytic reduction of organic pollutants","volume":"231","author":"Zheng","year":"2018","journal-title":"Appl. Catal. B Environ."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"11","DOI":"10.1016\/j.cej.2018.03.183","article-title":"Design of novel 3D flower-like neodymium molybdate: An efficient and challenging catalyst for sensing and destroying pulmonary toxicity antibiotic drug nitrofurantoin","volume":"346","author":"Karthik","year":"2018","journal-title":"Chem. Eng. J."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"129665","DOI":"10.1016\/j.chemosphere.2021.129665","article-title":"A Novel hybrid construction of MnMoO4 nanorods anchored graphene nanosheets; an efficient electrocatalyst for the picomolar detection of ecological pollutant ornidazole in water and urine samples","volume":"273","author":"Venkatesh","year":"2021","journal-title":"Chemosphere"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"700","DOI":"10.1016\/S0014-827X(00)00096-3","article-title":"Physico-chemical and solid-state characterization of secnidazole","volume":"55","author":"Rivera","year":"2000","journal-title":"Farmaco"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"19","DOI":"10.1016\/S0022-0728(79)80075-3","article-title":"General expression of the linear potential sweep voltammogram in the case of diffusionless electrochemical systems","volume":"101","author":"Laviron","year":"1979","journal-title":"J. Electroanal. Chem."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"687","DOI":"10.1590\/S1984-82502009000400011","article-title":"Bioavailability of two oral formulas of secnidazole in healthy volunteers","volume":"45","author":"Montovani","year":"2009","journal-title":"Braz. J. Pharm. Sci."},{"key":"ref_37","doi-asserted-by":"crossref","first-page":"769","DOI":"10.3923\/jbs.2002.769.770","article-title":"Analysis of blood for secnidazole in female volunteers by HPLC method","volume":"2","author":"Bibi","year":"2002","journal-title":"J. Biol. Sci."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/21\/6700\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:27:01Z","timestamp":1760167621000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/21\/6700"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,7]]},"references-count":37,"journal-issue":{"issue":"21","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ma14216700"],"URL":"https:\/\/doi.org\/10.3390\/ma14216700","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,7]]}}}