{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,2]],"date-time":"2026-10-02T05:37:34Z","timestamp":1790919454957,"version":"4.1.0"},"reference-count":52,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T00:00:00Z","timestamp":1636588800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Background: this study evaluates the clinical outcomes of a novel approach in treating deep intrabony defects utilizing papilla preservation techniques with a combination of hyaluronic acid (HA) and deproteinized porcine bone mineral. Methods: 23 patients with 27 intrabony defects were treated with a combination of HA and deproteinized porcine bone mineral. Clinical attachment level (CAL), pocket probing depth (PPD), gingival recession (REC) were recorded at baseline and 6 months after the surgery. Results: At 6 months, there was a significant CAL gain of 3.65 \u00b1 1.67 mm (p &lt; 0.001) with a PPD reduction of 4.54 \u00b1 1.65 mm (p &lt; 0.001), which was associated with an increase in gingival recession (0.89 \u00b1 0.59 mm, p &lt; 0.001). The percentage of pocket resolution based on a PPD \u22644 mm was 92.6% and the failure rate based on a PPD of 5 mm was 7.4%. Conclusions: the present findings indicate that applying a combined HA and xenograft approach in deep intrabony defects provides clinically relevant CAL gains and PPD reductions compared to baseline values and is a valid new approach in treating intrabony defects.<\/jats:p>","DOI":"10.3390\/ma14226795","type":"journal-article","created":{"date-parts":[[2021,11,11]],"date-time":"2021-11-11T23:04:46Z","timestamp":1636671886000},"page":"6795","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":25,"title":["Treatment of Intrabony Defects with a Combination of Hyaluronic Acid and Deproteinized Porcine Bone Mineral"],"prefix":"10.3390","volume":"14","author":[{"given":"Darko","family":"Bo\u017ei\u0107","sequence":"first","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Zagreb, HR-10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ivan","family":"\u0106atovi\u0107","sequence":"additional","affiliation":[{"name":"Private Dental Practice, HR-52100 Pula, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4300-9203","authenticated-orcid":false,"given":"Ana","family":"Badovinac","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Zagreb, HR-10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2946-2124","authenticated-orcid":false,"given":"Larisa","family":"Musi\u0107","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Zagreb, HR-10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2846-1840","authenticated-orcid":false,"given":"Matej","family":"Par","sequence":"additional","affiliation":[{"name":"Department of Endodontics and Restorative Dentistry, School of Dental Medicine, University of Zagreb, HR-10000 Zagreb, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2836-5477","authenticated-orcid":false,"given":"Anton","family":"Sculean","sequence":"additional","affiliation":[{"name":"Department of Periodontology, School of Dental Medicine, University of Bern, CH-3010 Bern, Switzerland"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,11,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"57","DOI":"10.1111\/prd.12362","article-title":"Microbial Signatures of Health, Gingivitis, and Periodontitis","volume":"86","author":"Abusleme","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"8","DOI":"10.1111\/prd.12374","article-title":"Oral Biofilms Revisited: A Novel Host Tissue of Bacteriological Origin","volume":"86","author":"Darveau","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"32","DOI":"10.1111\/prd.12361","article-title":"The Dental Plaque Biofilm Matrix","volume":"86","author":"Jakubovics","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"201","DOI":"10.1111\/prd.12377","article-title":"Microbial Transitions from Health to Disease","volume":"86","author":"Joseph","year":"2021","journal-title":"Periodontol. 2000"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"592","DOI":"10.1177\/0022034513490168","article-title":"Global Burden of Oral Conditions in 1990-2010: A Systematic Analysis","volume":"92","author":"Marcenes","year":"2013","journal-title":"J. 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Periodontol."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/22\/6795\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:28:25Z","timestamp":1760167705000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/14\/22\/6795"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,11,11]]},"references-count":52,"journal-issue":{"issue":"22","published-online":{"date-parts":[[2021,11]]}},"alternative-id":["ma14226795"],"URL":"https:\/\/doi.org\/10.3390\/ma14226795","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,11,11]]}}}