{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,11,18]],"date-time":"2025-11-18T12:26:07Z","timestamp":1763468767324,"version":"build-2065373602"},"reference-count":59,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T00:00:00Z","timestamp":1640649600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001807","name":"S\u00e3o Paulo Research Foundation","doi-asserted-by":"publisher","award":["2017\/20222-9 and 2017\/08187-3"],"award-info":[{"award-number":["2017\/20222-9 and 2017\/08187-3"]}],"id":[{"id":"10.13039\/501100001807","id-type":"DOI","asserted-by":"publisher"}]},{"name":"ARDEC Academy, Rimini, Italy","award":["NA"],"award-info":[{"award-number":["NA"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>(1) Background: There are many therapies for osteoporosis control and bone maintenance; anabolic drugs such as teriparatide and bone grafts help in the repair process and stimulate bone formation. Thus, the aim of the present study was to evaluate the behavior of repaired bone in the presence of PTH (teriparatide) associated with Biogran\u00ae (biomaterial) through a sonochemical procedure after extraction in rats. (2) Methods: The insertion of Biogran\u00ae with PTH in the alveolus was performed 30 days after incisor extraction. Euthanasia occurred after 60 days. (3) Results: The use of local treatment of PTH loaded with Biogran\u00ae in healthy rats promoted good results for micro-CT, with an increase in percentage and bone volume, number and trabecular separation and less total porosity. Greater immunostaining for Wnt, \u03b2-Catenin and osteocalcin proteins and lower expression for Thrombospondin-Related Adhesive Protein (TRAP), which shows an increase in the number of osteoblasts and inhibition of osteoclast action. However, the treated orchiectomized groups did not obtain such expressive results. (4) Conclusion: The use of Biogran\u00ae with PTH improved alveolar repair in rats. However, new researches with more efficient doses must be studied to collaborate effectively with the formation of a quality bone after the orchiectomy.<\/jats:p>","DOI":"10.3390\/ma15010207","type":"journal-article","created":{"date-parts":[[2021,12,28]],"date-time":"2021-12-28T06:55:03Z","timestamp":1640674503000},"page":"207","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":11,"title":["Effect of Topical PTH 1-34 Functionalized to Biogran\u00ae in the Process of Alveolar Repair in Rats Submitted to Orchiectomy"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5012-5093","authenticated-orcid":false,"given":"Paula Buzo","family":"Frig\u00e9rio","sequence":"first","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pedro Henrique Silva","family":"Gomes-Ferreira","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"F\u00e1bio Roberto","family":"de Souza Batista","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Juliana","family":"Moura","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Idelmo","family":"Rangel Garcia J\u00fanior","sequence":"additional","affiliation":[{"name":"Department of Diagnosis and Surgery, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2804-1632","authenticated-orcid":false,"given":"Daniele","family":"Botticelli","sequence":"additional","affiliation":[{"name":"ARDEC Academy, 47923 Rimini, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7734-4069","authenticated-orcid":false,"given":"Paulo Noronha","family":"Lisboa-Filho","sequence":"additional","affiliation":[{"name":"Department of Physics, School of Sciences, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Bauru 17033360, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6773-6966","authenticated-orcid":false,"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Basic Sciences, Ara\u00e7atuba Dental School, S\u00e3o Paulo State University J\u00falio de Mesquita Filho\u2014UNESP, Aracatuba 16015050, SP, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,28]]},"reference":[{"key":"ref_1","unstructured":"International Osteoporosis Foundation (2021, February 10). 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