{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,25]],"date-time":"2026-06-25T22:16:49Z","timestamp":1782425809889,"version":"3.54.5"},"reference-count":35,"publisher":"MDPI AG","issue":"1","license":[{"start":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T00:00:00Z","timestamp":1640736000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The purpose of the present study was to evaluate the histological and histomorphometric characteristics of post-extraction sites grafted with decellularized bovine compact bone from bovine femur, mixed and unmixed with leukocyte- and platelet-rich fibrin after four months of healing. This study was designed as a randomized controlled trial of parallel groups. Patients in need of a single, implant-supported restoration to replace a hopeless tooth were recruited for tooth extraction and implant placement four months after socket preservation procedure. After tooth extraction, patients were randomly allocated to receive decellularized bovine compact bone from bovine femur, mixed and unmixed with leukocyte- and platelet-rich fibrin. After four months of healing, tapered implants were inserted with an insertion torque between 35 and 45 Ncm. Two months later, implants were loaded with screw-retained definitive crowns. Outcome measures were implant (ISR) and prosthesis (PSR) survival rates, complications, histological and histomorphometric analyses, radiographic marginal bone-level changes, and patients\u2019 satisfaction. Clinical data were collected up to one year after tooth extraction and socket preservation procedures. Thirty patients were consecutively enrolled in the trial (15 in each group). Unfortunately, due to the COVID-19 pandemic, bone samples were collected only in 19 patients. Two implants failed before definitive prosthesis delivery (ISR 93.3%). No prosthesis failed (PSR 100%). Three complications were experienced in the control group. The mean bone percentage was 40.64 \u00b1 18.76 in the test group and 33.40 \u00b1 22.38 in the control group. The difference was not statistically significant (p = 0.4846). The mean soft tissue percentage was 32.55 \u00b1 19.45 in the test group and 55.23 \u00b1 17.64 in the control group. The difference was statistically significant (p = 0.0235). The mean residual graft was 24.59 \u00b1 18.39 in the test group and 11.37 \u00b1 12.12 in the control group. The difference was not statistically significant (p = 0.0992). Mean marginal bone loss, as well as patient satisfaction, showed no differences between groups. With the limitations of the present study, socket preservation with L-PRF mixed with decellularized bovine compact bone demonstrated favorable results, comparing with decellularized bovine compact bone from bovine femur alone. Further studies with larger sample size and longer follow-up are needed to confirm these preliminary results.<\/jats:p>","DOI":"10.3390\/ma15010254","type":"journal-article","created":{"date-parts":[[2021,12,29]],"date-time":"2021-12-29T23:31:35Z","timestamp":1640820695000},"page":"254","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["Histological and Histomorphometric Evaluation of Post-Extractive Sites Filled with a New Bone Substitute with or without Autologous Plate Concentrates: One-Year Randomized Controlled Trial"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-9206-0454","authenticated-orcid":false,"given":"Marco","family":"Tallarico","sequence":"first","affiliation":[{"name":"School of Dentistry, University of Sassari, 07021 Sassari, Italy"},{"name":"Department of Implantology, Faculty of Dentistry, University of Aldent, 1031 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Erta","family":"Xhanari","sequence":"additional","affiliation":[{"name":"Department of Implantology, Faculty of Dentistry, University of Aldent, 1031 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Aurea Maria Immacolata","family":"Lumbau","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Sassari, 07021 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Adela","family":"Alushi","sequence":"additional","affiliation":[{"name":"Department of Implantology, Faculty of Dentistry, University of Aldent, 1031 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Irene","family":"Ieria","sequence":"additional","affiliation":[{"name":"Private Practice, 00151 Rome, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0335-4165","authenticated-orcid":false,"given":"Luca","family":"Fiorillo","sequence":"additional","affiliation":[{"name":"Department of Implantology, Faculty of Dentistry, University of Aldent, 1031 Tirana, Albania"},{"name":"Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, 98122 Messina, Italy"},{"name":"Multidisciplinary Department of Medical-Surgical and Odontostomatological Specialties, University of Campania \u201cLuigi Vanvitelli\u201d, 81100 Naples, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9017-1991","authenticated-orcid":false,"given":"Fausto","family":"Fam\u00e0","sequence":"additional","affiliation":[{"name":"Department of Human Pathology in Adulthood and Childhood \u201cG. Barresi\u201d, University Hospital \u201cG. Martino\u201d of Messina, Via Consolare Valeria 1, 98125 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1659-2453","authenticated-orcid":false,"given":"Agron","family":"Meto","sequence":"additional","affiliation":[{"name":"Department of Implantology, Faculty of Dentistry, University of Aldent, 1031 Tirana, Albania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Edoardo","family":"Baldoni","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Sassari, 07021 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvio Mario","family":"Meloni","sequence":"additional","affiliation":[{"name":"School of Dentistry, University of Sassari, 07021 Sassari, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2311-9728","authenticated-orcid":false,"given":"Marco","family":"Cicci\u00f9","sequence":"additional","affiliation":[{"name":"Department of Biomedical, Dental Science and Morphological and Functional Images, University of Messina, 98122 Messina, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2021,12,29]]},"reference":[{"key":"ref_1","first-page":"313","article-title":"Bone healing and soft tissue contour changes following single-tooth extraction: A clinical and radiographic 12-month prospective study","volume":"23","author":"Schropp","year":"2003","journal-title":"Int. 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Materials, 13.","DOI":"10.3390\/ma13173874"}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/15\/1\/254\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T07:55:41Z","timestamp":1760169341000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/15\/1\/254"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2021,12,29]]},"references-count":35,"journal-issue":{"issue":"1","published-online":{"date-parts":[[2022,1]]}},"alternative-id":["ma15010254"],"URL":"https:\/\/doi.org\/10.3390\/ma15010254","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2021,12,29]]}}}