{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:53:23Z","timestamp":1760151203246,"version":"build-2065373602"},"reference-count":36,"publisher":"MDPI AG","issue":"4","license":[{"start":{"date-parts":[[2022,2,11]],"date-time":"2022-02-11T00:00:00Z","timestamp":1644537600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The use of nanomedicines for cancer treatment has been widespread. Fullerenes have significant effects in the treatment of solid tumors. Here, we are going to study the effects of hydroxylated fullerene C60(OH)n(n = 18\u201322) treatment on chronic myeloid leukemia cell proliferation and investigate its toxicity. The results showed that hydroxylated fullerene C60(OH)n (n = 18\u201322) at low concentrations (less than 120 \u03bcM) not only had apparent toxic side effects, but also promoted the growth of K562 cells, while a high concentration of C60(OH)n had different degrees of inhibition on K562 cells. When the concentration is higher than 160 \u03bcM, the K562 cells showed morphological changes, the mitochondrial membrane potential decreased, the cell cycle was blocked in the stage of G2-phase, and cell apoptosis occurred, which may cause apoptosis, autophagy, and a variety of other damage leading to cell death. Meanwhile, it also indicated that its inhibition of solid tumors might be related to the tumor microenvironment; we verified the safety of fullerene without apparent cellular toxicity at a specific concentration.<\/jats:p>","DOI":"10.3390\/ma15041349","type":"journal-article","created":{"date-parts":[[2022,2,13]],"date-time":"2022-02-13T20:34:45Z","timestamp":1644784485000},"page":"1349","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":6,"title":["The Effect of Polyhydroxy Fullerene Derivative on Human Myeloid Leukemia K562 Cells"],"prefix":"10.3390","volume":"15","author":[{"given":"Wei","family":"Guo","sequence":"first","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Xing","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6265-9124","authenticated-orcid":false,"given":"Lianjie","family":"Ye","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Shaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jie","family":"Liu","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Kollie","family":"Larwubah","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ge","family":"Meng","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Weiqiang","family":"Shen","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2885-2657","authenticated-orcid":false,"given":"Xiangxian","family":"Ying","sequence":"additional","affiliation":[{"name":"College of Biological and Environmental Engineering, Zhejiang University of Technology, Hangzhou 310014, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jun","family":"Zhu","sequence":"additional","affiliation":[{"name":"Hangzhou Wahaha Co., Ltd., Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Shengjie","family":"Yang","sequence":"additional","affiliation":[{"name":"Shaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China"},{"name":"Hangzhou Wahaha Co., Ltd., Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Jianjun","family":"Guo","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Shaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Yanrong","family":"Jia","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Meilan","family":"Yu","sequence":"additional","affiliation":[{"name":"College of Life Science and Medicine, Zhejiang Sci-Tech University, Hangzhou 310018, China"},{"name":"Shaoxing Academy of Biomedicine, Zhejiang Sci-Tech University, Shaoxing 312030, China"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"162","DOI":"10.1038\/318162a0","article-title":"C60: Buckminsterfullerene","volume":"318","author":"Kroto","year":"1985","journal-title":"Nature"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9434","DOI":"10.1073\/pnas.94.17.9434","article-title":"Carboxyfullerenes as neuroprotectiveagents","volume":"94","author":"Dugan","year":"1997","journal-title":"Proc. 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