{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:52:36Z","timestamp":1760151156445,"version":"build-2065373602"},"reference-count":37,"publisher":"MDPI AG","issue":"5","license":[{"start":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T00:00:00Z","timestamp":1646006400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>This study aimed to compare two beta-tricalcium phosphates with different particle sizes in human maxillary sinuses lifting. The immunolabeling of cells for RUNX2 and VEGF were performed to evaluate the osteoblast precursor cells and the vascular formation after 6 months of bone repair. Ten maxillary sinuses were grafted with autogenous bone graft (Group 1), 10 were grafted with ChronOs\u00ae (Group 2), and 10 were grafted with BETA-TCP\u00ae (Group 3). After 6 months of bone healing, biopsies were obtained to assess the new bone formed by histomorphometric and immunohistochemical evaluation for RUNX2 and VEGF. The mean bone formation for Group 1 was 51.4 \u00b1 17.4%. Group 2 presented 45.5 \u00b1 9.9%, and Group 3 conferred 35.4 \u00b1 8.0% of new bone formation. The RUNX2 offered low for Groups 1 and 2 with high cellular activity for osteoblast in Group 3. The VEGF immunolabeling was moderate for Groups 1 and 2 and intense for Group 3. In conclusion, it was possible to show that the bone substitutes evaluated in the present study presented suitable outcomes for bone regeneration, being an alternative for the autogenous bone graft in maxillary sinus bone height reconstruction.<\/jats:p>","DOI":"10.3390\/ma15051824","type":"journal-article","created":{"date-parts":[[2022,2,28]],"date-time":"2022-02-28T20:11:14Z","timestamp":1646079074000},"page":"1824","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Evaluation of Two Beta-Tricalcium Phosphates with Different Particle Dimensions in Human Maxillary Sinus Floor Elevation: A Prospective, Randomized Clinical Trial"],"prefix":"10.3390","volume":"15","author":[{"given":"Bruno Coelho","family":"Mendes","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-8633","authenticated-orcid":false,"given":"Rodrigo dos Santos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, University of Grande Rio\u2014UNIGRANRIO, Rio de Janeiro 25071-202, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-0222","authenticated-orcid":false,"given":"Carlos Fernando de Almeida Barros","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Clinical Research Unit of the Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Montemezzi","sequence":"additional","affiliation":[{"name":"Clinical Research Unit of the Antonio Pedro Hospital, Fluminense Federal University, Niteroi 24033-900, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anderson Maikon de Souza","family":"Santos","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8808-4872","authenticated-orcid":false,"given":"J\u00e9ssica Monique Lopes","family":"Moreno","sequence":"additional","affiliation":[{"name":"Department of Dental Prosthesis, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Hochuli-Vieira","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,2,28]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"665","DOI":"10.1016\/j.ijom.2017.11.016","article-title":"Comparative study of volumetric changes and trabecular microarchitecture in human maxillary sinus bone augmentation with bioactive glass and autogenous bone graft: A prospective and randomized assessment","volume":"47","author":"Pereira","year":"2018","journal-title":"Int. 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