{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,12]],"date-time":"2026-06-12T23:31:24Z","timestamp":1781307084114,"version":"3.54.1"},"reference-count":29,"publisher":"MDPI AG","issue":"9","license":[{"start":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T00:00:00Z","timestamp":1650844800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>For the surgical technique of guided bone regeneration (GBR), the choice of available barrier membranes has until recently not included an option that is mechanically strong, durable, synthetic and resorbable. The most commonly used resorbable membranes are made from collagen, which are restricted in their mechanical strength. The purpose of this study is to evaluate the degradation and regeneration potential of a magnesium membrane compared to a collagen membrane. In eighteen beagle dogs, experimental bone defects were filled with bovine xenograft and covered with either a magnesium membrane or collagen membrane. The health status of the animals was regularly monitored and recorded. Following sacrifice, the hemimandibles were prepared for micro-CT (\u03bc-CT) analysis. Complications during healing were observed in both groups, but ultimately, the regenerative outcome was similar between groups. The \u03bc-CT parameters showed comparable results in both groups in terms of new bone formation at all four time points. In addition, the \u03bc-CT analysis showed that the greatest degradation of the magnesium membranes occurred between 1 and 8 weeks and continued until week 16. The proportion of new bone within the defect site was similar for both treatment groups, indicating the potential for the magnesium membrane to be used as a viable alternative to collagen membranes. Overall, the new magnesium membrane is a functional and safe membrane for the treatment of defects according to the principles of GBR.<\/jats:p>","DOI":"10.3390\/ma15093106","type":"journal-article","created":{"date-parts":[[2022,4,25]],"date-time":"2022-04-25T21:16:28Z","timestamp":1650921388000},"page":"3106","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":35,"title":["Analysis of a Pure Magnesium Membrane Degradation Process and Its Functionality When Used in a Guided Bone Regeneration Model in Beagle Dogs"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7199","authenticated-orcid":false,"given":"Patrick","family":"Rider","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"},{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka Peri\u0107","family":"Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"},{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"},{"name":"Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiva","family":"Elad","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rothamel","sequence":"additional","affiliation":[{"name":"CMF Surgery, Johannes BLA Hospital, 41239 M\u00f6nchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Sauer","sequence":"additional","affiliation":[{"name":"CMF Surgery, Johannes BLA Hospital, 41239 M\u00f6nchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Bornert","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire de Strasbourg, Universit\u00e9 de Strasbourg, 8 rue Sainte-Elisabeth, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peter","family":"Windisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Hangy\u00e1si","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-4873","authenticated-orcid":false,"given":"Balint","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hesse","sequence":"additional","affiliation":[{"name":"Xploraytion GmbH, Bismarkstrasse 11, 10625 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2014Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,4,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1902\/jop.2012.120314","article-title":"Rehabilitation of deficient alveolar ridges using titanium grids before and simultaneously with implant placement: A systematic review","volume":"84","author":"Ricci","year":"2013","journal-title":"J Periodontol."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1007\/s10266-016-0267-0","article-title":"Collagen based barrier membranes for periodontal guided bone regeneration applications","volume":"105","author":"Sheikh","year":"2017","journal-title":"Odontology"},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"263","DOI":"10.4103\/ams.ams_76_17","article-title":"Guided Bone Regeneration for the Reconstruction of Alveolar Bone Defects","volume":"7","author":"Khojasteh","year":"2017","journal-title":"Ann. 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