{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:53:45Z","timestamp":1787028825197,"version":"build-2736575974"},"reference-count":73,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T00:00:00Z","timestamp":1653436800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"National Natural Science Foundation of China (NSFC)","award":["82071050"],"award-info":[{"award-number":["82071050"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["2020G2RPYMS12"],"award-info":[{"award-number":["2020G2RPYMS12"]}]},{"name":"National Natural Science Foundation of China (NSFC)","award":["201803010093"],"award-info":[{"award-number":["201803010093"]}]},{"name":"Science and Technology Planning Project of Guangzhou, China","award":["82071050"],"award-info":[{"award-number":["82071050"]}]},{"name":"Science and Technology Planning Project of Guangzhou, China","award":["2020G2RPYMS12"],"award-info":[{"award-number":["2020G2RPYMS12"]}]},{"name":"Science and Technology Planning Project of Guangzhou, China","award":["201803010093"],"award-info":[{"award-number":["201803010093"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The inner ear is located deep in the temporal bone and has a complex anatomy. It is difficult to observe and obtain pathological tissues directly. Therefore, the diagnosis and treatment of inner ear diseases have always been a major clinical problem. The onset of inner ear disease can be accompanied by symptoms such as hearing loss, dizziness and tinnitus, which seriously affect people\u2019s lives. Nanoparticles have the characteristics of small size, high bioavailability and strong plasticity. With the development of related research on nanoparticles in inner ear diseases, nanoparticles have gradually become a research hotspot in inner ear diseases. This review briefly summarizes the research progress, opportunities and challenges of the application of nanoparticles in inner ear diseases.<\/jats:p>","DOI":"10.3390\/ma15113780","type":"journal-article","created":{"date-parts":[[2022,5,25]],"date-time":"2022-05-25T08:41:33Z","timestamp":1653468093000},"page":"3780","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":23,"title":["Nanomaterials for Inner Ear Diseases: Challenges, Limitations and Opportunities"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0001-5696-4202","authenticated-orcid":false,"given":"Liling","family":"Li","sequence":"first","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tianhe Road, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jia","family":"Luo","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tianhe Road, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xuexin","family":"Lin","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tianhe Road, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jingqian","family":"Tan","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Eighth Affiliated Hospital of Sun Yat-sen University, Shenzhen 518033, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peng","family":"Li","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology Head and Neck Surgery, The Third Affiliated Hospital of Sun Yat-sen University, No.600 Tianhe Road, Guangzhou 510630, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"3098230","DOI":"10.1155\/2017\/3098230","article-title":"Nanomedicine for Inner Ear Diseases: A Review of Recent In Vivo Studies","volume":"2017","author":"Kim","year":"2017","journal-title":"BioMed Res. 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