{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,1,21]],"date-time":"2026-01-21T10:47:30Z","timestamp":1768992450997,"version":"3.49.0"},"reference-count":27,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,27]],"date-time":"2022-05-27T00:00:00Z","timestamp":1653609600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ministry of Health Care of Russian Federation","award":["State Task Order 121031100308-0"],"award-info":[{"award-number":["State Task Order 121031100308-0"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Various gadolinium compounds have been proposed as contrasting agents for magnetic resonance imaging (MRI). In this study, we suggested a new synthesis method of gadolinium ferrate\/trigadolinium pentairon(III) oxide nanoparticles (GF\/TPO NPs). The specific surface area of gadolinium ferrate (GdFeO3) and trigadolinium pentairon(III) oxide (Gd3Fe5O12) nanoparticles was equal to 42 and 66 m2\/g, respectively. The X-ray diffraction analysis confirmed that the synthesized substances were GdFeO3 and Gd3Fe5O12. The gadolinium content in the samples was close to the theoretically calculated value. The free gadolinium content was negligible. Biodistribution of the GF\/TPO NPs was studied in rats by fluorescent imaging and Fe2+\/Fe3+ quantification demonstrating predominant accumulation in such organs as lung, kidney, and liver. We showed in the in vivo rat model of myocardial ischemia\u2013reperfusion injury that GF\/TPO NPs are able to target the area of myocardial infarction as evidenced by the significantly greater level of fluorescence. In perspective, the use of fluorescently labeled GF\/TPO NPs in multimodal imaging may provide basis for high-resolution 3D reconstruction of the infarcted heart, thereby serving as unique theranostic platform.<\/jats:p>","DOI":"10.3390\/ma15113832","type":"journal-article","created":{"date-parts":[[2022,5,28]],"date-time":"2022-05-28T01:40:45Z","timestamp":1653702045000},"page":"3832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Fluorescently Labeled Gadolinium Ferrate\/Trigadolinium Pentairon(III) Oxide Nanoparticles: Synthesis, Characterization, In Vivo Biodistribution, and Application for Visualization of Myocardial Ischemia\u2013Reperfusion Injury"],"prefix":"10.3390","volume":"15","author":[{"given":"Dmitry V.","family":"Korolev","sequence":"first","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"},{"name":"Laboratory of Blood Circulation Biophysics, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Galina A.","family":"Shulmeyster","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Maria S.","family":"Istomina","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"},{"name":"Department of Nano- and Microelectronics, Saint-Petersburg Electrotechnical University \u201cLETI\u201d, Saint-Petersburg 197376, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Natalia V.","family":"Evreinova","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"},{"name":"Department of Electrochemical Production, Saint-Petersburg State Institute of Technology, Saint-Petersburg 190013, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8286-8070","authenticated-orcid":false,"given":"Ilia V.","family":"Aleksandrov","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aleksandr S.","family":"Krasichkov","sequence":"additional","affiliation":[{"name":"Department of Radio Engineering Systems, Saint-Petersburg Electrotechnical University \u201cLETI\u201d, Saint-Petersburg 197376, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Viktor N.","family":"Postnov","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"},{"name":"Institute of Chemistry, Saint-Petersburg State University, Saint-Petersburg 199034, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Michael M.","family":"Galagudza","sequence":"additional","affiliation":[{"name":"Institute of Experimental Medicine, Almazov National Medical Research Centre, Saint-Petersburg 197341, Russia"},{"name":"Department of Pathophysiology with Clinical Pathophysiology Course, Pavlov First Saint-Petersburg State Medical University, Saint-Petersburg 197022, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,27]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"398","DOI":"10.1080\/1061186X.2019.1669040","article-title":"Gadolinium-conjugated CB86: A novel TSPO-targeting MRI contrast agent for imaging of rheumatoid arthritis","volume":"28","author":"Hou","year":"2020","journal-title":"J. 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