{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,23]],"date-time":"2026-09-23T17:27:08Z","timestamp":1790184428458,"version":"4.1.0"},"reference-count":60,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T00:00:00Z","timestamp":1653782400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Energy and Resources Institute"},{"name":"Deakin University"},{"name":"Deakin University HDR scholarship"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Gold nanoparticles (GNP) were bio-fabricated utilizing the methanolic extract of the endophytic isolate Aspergillus terreus. The biosynthesised gold nanoparticles (GNP023) were characterised using UV-visible spectroscopy (UV-Vis); transmission electron microscopy (TEM), Fourier-transform nfrared spectroscopy (FTIR) and X-ray diffraction (XRD) studies. The bio-fabricated GNP023 displayed a sharp SPR peak at 536 nm, were spherically shaped, and had an average size between 10\u201316 nm. The EDX profile confirmed the presence of gold (Au), and XRD analysis confirmed the crystalline nature of GNP023. The antimicrobial activity of GNP023 was investigated against several food-borne and phytopathogens, using in vitro antibacterial and antifungal assays. The maximum zone of inhibition was observed for S. aureus and V. cholera at 400 \u03bcg \/mL, whereas inhibition in radial mycelial growth was observed against Fusarium oxysporum and Rhizoctonia solani at 52.5% and 65.46%, respectively, when challenged with GNP023 (200 \u03bcg\/mL). Moreover, the gold nanoparticles displayed significant antioxidant activity against the ABTS radical, with an IC50 of 38.61 \u00b5g\/mL, and were non-toxic when tested against human kidney embryonic 293 (HEK293) cells. Thus, the current work supports the application of myco-synthesised gold nanoparticles as a versatile antimicrobial candidate against food-borne pathogens.<\/jats:p>","DOI":"10.3390\/ma15113877","type":"journal-article","created":{"date-parts":[[2022,5,29]],"date-time":"2022-05-29T08:50:51Z","timestamp":1653814251000},"page":"3877","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":32,"title":["Bio-Synthesis of Aspergillus terreus Mediated Gold Nanoparticle: Antimicrobial, Antioxidant, Antifungal and In Vitro Cytotoxicity Studies"],"prefix":"10.3390","volume":"15","author":[{"given":"Rahul Chandra","family":"Mishra","sequence":"first","affiliation":[{"name":"TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), TERI GRAM, Gurgaon 122001, India"},{"name":"Centre for Bioprocessing, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Rishu","family":"Kalra","sequence":"additional","affiliation":[{"name":"TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), TERI GRAM, Gurgaon 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9208-6045","authenticated-orcid":false,"given":"Rahul","family":"Dilawari","sequence":"additional","affiliation":[{"name":"CSIR-Institute of Microbial Technology, Sector-39-A, Chandigarh 160036, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mayurika","family":"Goel","sequence":"additional","affiliation":[{"name":"TERI-Deakin Nano Biotechnology Centre, The Energy and Resources Institute (TERI), TERI GRAM, Gurgaon 122001, India"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-2153-7267","authenticated-orcid":false,"given":"Colin J.","family":"Barrow","sequence":"additional","affiliation":[{"name":"Centre for Bioprocessing, School of Life and Environmental Sciences, Deakin University, Waurn Ponds, VIC 3220, Australia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,5,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"781","DOI":"10.1007\/s12649-018-0540-2","article-title":"Biofabrication of gold nanoparticles using xylanases through valorization of corncob by Aspergillus niger and Trichoderma longibrachiatum: Antimicrobial, antioxidant, anticoagulant and thrombolytic activities","volume":"11","author":"Elegbede","year":"2020","journal-title":"Waste Biomass Valorization"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"433","DOI":"10.1109\/TNB.2016.2559161","article-title":"Biomedical and catalytic applications of gold and silver-gold alloy nanoparticles biosynthesized using cell-free extract of Bacillus safensis LAU 13: Antifungal, dye degradation, anti-coagulant and thrombolytic activities","volume":"15","author":"Ojo","year":"2016","journal-title":"IEEE Trans. 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