{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,30]],"date-time":"2026-09-30T23:48:57Z","timestamp":1790812137486,"version":"4.1.0"},"reference-count":34,"publisher":"MDPI AG","issue":"12","license":[{"start":{"date-parts":[[2022,6,9]],"date-time":"2022-06-09T00:00:00Z","timestamp":1654732800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Nowadays, the most commonly used fixation systems are non-resorbable, but new resorbable magnesium alloy fixation screws have been introduced recently. Therefore, the aim of this study was to compare the magnesium fixation screw and the commonly used non-resorbable titanium screw in an animal model. Four 3-wall defect sites were covered with collagen membranes in the mandible of twenty beagle dogs (two sites on the left and two on the right). Each membrane was fixed with either four magnesium screws or four titanium screws. Post-operative follow-up revealed the expected observations such as transient inflammation and pain. Both groups showed a good healing response, with no differences between groups. Micro-CT analysis showed no significant difference between groups in terms of BV\/TV or soft tissue volume. The void volume in the magnesium fixation screw group continued to decrease on average between the different timepoints, but not significantly. Furthermore, a gradual progression of the degradation process of the magnesium screws was observed in the same group. Magnesium screws and titanium screws showed equal performance in tissue regeneration according to GBR principles. An additional advantage of magnesium screws is their resorbable nature, which eliminates the need for a second surgical step to remove the screws.<\/jats:p>","DOI":"10.3390\/ma15124111","type":"journal-article","created":{"date-parts":[[2022,6,12]],"date-time":"2022-06-12T09:26:48Z","timestamp":1655026008000},"page":"4111","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":24,"title":["Biodegradation of a Magnesium Alloy Fixation Screw Used in a Guided Bone Regeneration Model in Beagle Dogs"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3620-7199","authenticated-orcid":false,"given":"Patrick","family":"Rider","sequence":"first","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"},{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8250-723X","authenticated-orcid":false,"given":"\u017deljka Peri\u0107","family":"Ka\u010darevi\u0107","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"},{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"},{"name":"Department of Anatomy Histology, Embryology, Pathology Anatomy and Pathology Histology, Faculty of Dental Medicine and Health, University of Osijek, 31000 Osijek, Croatia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Akiva","family":"Elad","sequence":"additional","affiliation":[{"name":"Botiss Biomaterials AG, Ullsteinstrasse 108, 12109 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniel","family":"Rothamel","sequence":"additional","affiliation":[{"name":"CMF Surgery, Johannes BLA Hospital, 41239 M\u00f6nchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Gerrit","family":"Sauer","sequence":"additional","affiliation":[{"name":"CMF Surgery, Johannes BLA Hospital, 41239 M\u00f6nchengladbach, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Fabien","family":"Bornert","sequence":"additional","affiliation":[{"name":"Facult\u00e9 de Chirurgie Dentaire de Strasbourg, Universit\u00e9 de Strasbourg, 8 Rue Sainte-Elisabeth, 67000 Strasbourg, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6891-6494","authenticated-orcid":false,"given":"Peter","family":"Windisch","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"D\u00e1vid","family":"Hangy\u00e1si","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6307-4873","authenticated-orcid":false,"given":"Balint","family":"Molnar","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Semmelweis University, 1769 Budapest, Hungary"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bernhard","family":"Hesse","sequence":"additional","affiliation":[{"name":"Xploraytion GmbH, Bismarkstrasse 11, 10625 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8734-0267","authenticated-orcid":false,"given":"Michel","family":"Assad","sequence":"additional","affiliation":[{"name":"Medical Device Preclinical Services, Charles River Laboratories, 1635 Lionel-Bertrand Blvd., Boisbriand, QC J7H 1N8, Canada"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Frank","family":"Witte","sequence":"additional","affiliation":[{"name":"Department of Prosthodontics, Geriatric Dentistry and Craniomandibular Disorders, Charit\u00e9\u2013Universit\u00e4tsmedizin Berlin, A\u00dfmannshauser Stra\u00dfe 4\u20136, 14197 Berlin, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,6,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1234","DOI":"10.1902\/jop.2012.120314","article-title":"Rehabilitation of Deficient Alveolar Ridges Using Titanium Grids Before and Simultaneously With Implant Placement: A Systematic Review","volume":"84","author":"Ricci","year":"2013","journal-title":"J. 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