{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,27]],"date-time":"2026-05-27T20:13:41Z","timestamp":1779912821203,"version":"3.53.1"},"reference-count":41,"publisher":"MDPI AG","issue":"17","license":[{"start":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T00:00:00Z","timestamp":1661731200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The medical field has undergone constant development in recent years, and a segment of this development is occupied by biodegradable alloys. The most common alloys in this field are those based on Mg, their main advantage being the ability to degrade gradually, without affecting the patient, and also their ability to be fully absorbed by the human body. One of their most important conditions is the regeneration and replacement of human tissue. Tissue can be engineered in different ways, one being tissue regeneration in vivo, which can serve as a template. In vivo remodeling aims to restore tissue or organs. The key processes of tissue formation and maturation are: proliferation (sorting and differentiation of cells), proliferation and organization of the extracellular matrix, biodegradation of the scaffold-remodeling, and potential tissue growth. In the present paper, the design of the alloys in the Mg-Ca-Y system is formed from the beginning using high-purity components, Mg-98.5%, master-alloys: Mg-Y (70 wt.%\u201330 wt.%) and Mg-Ca (85 wt.%\u201315 wt.%). After 8 weeks of implantation, the degradation of the implanted material is observed, and only small remaining fragments are found. At the site of implantation, no inflammatory reaction is observed, but it is observed that the process of integration and reabsorption, over time, accentuates the prosaic surface of the material. The aim of the work is to test the biocompatibility of magnesium-based alloys on laboratory rats in order to use these alloys in medical applications. The innovative parts of these analyses are the chemical composition of the alloys used and the tests performed on laboratory animals.<\/jats:p>","DOI":"10.3390\/ma15175958","type":"journal-article","created":{"date-parts":[[2022,8,29]],"date-time":"2022-08-29T03:34:56Z","timestamp":1661744096000},"page":"5958","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Long-Term Examination of Degradation and In Vivo Biocompatibility of Some Mg-0.5Ca-xY Alloys in Sprague Dawley Rats"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6406-8130","authenticated-orcid":false,"given":"\u0218tefan","family":"Lupescu","sequence":"first","affiliation":[{"name":"Department of Mechanics and Technologies, Stefan cel Mare University of Suceava, 13 University Street, 720229 Suceava, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Corneliu","family":"Munteanu","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania"},{"name":"Technical Sciences Academy of Romania, 26 Dacia Blvd, 030167 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Eusebiu Viorel","family":"Sindilar","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine of Lasi, \u201cIon Ionescu de la Brad\u201d Ia\u0219i University of Life Sciences (IULS), nr.8, Mihail Sadoveanu Alley, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0817-3523","authenticated-orcid":false,"given":"Bogdan","family":"Istrate","sequence":"additional","affiliation":[{"name":"Mechanical Engineering Department, Gheorghe Asachi University of Iasi, 6 D. Mangeron Blvd, 700050 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Iuliana","family":"Mihai","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine of Lasi, \u201cIon Ionescu de la Brad\u201d Ia\u0219i University of Life Sciences (IULS), nr.8, Mihail Sadoveanu Alley, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Bogdan","family":"Oprisan","sequence":"additional","affiliation":[{"name":"Faculty of Medicine, \u201cGrigore T. Popa\u201d University of Medicine and Pharmacy from Iasi, Universit\u0103\u021bii 16 Street, 700115 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9519-8122","authenticated-orcid":false,"given":"Aurelian-Sorin","family":"Pasca","sequence":"additional","affiliation":[{"name":"Faculty of Veterinary Medicine of Lasi, \u201cIon Ionescu de la Brad\u201d Ia\u0219i University of Life Sciences (IULS), nr.8, Mihail Sadoveanu Alley, 700490 Iasi, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,8,29]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"2250","DOI":"10.1056\/NEJMra053077","article-title":"Bone quality\u2014The material and structural basis of bone strength and fragility","volume":"354","author":"Seeman","year":"2006","journal-title":"N. Engl. J. 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