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However, the complex fabrication process of such flexible devices results in high prices, limiting their applications in real-life scenarios. This study proposes a flexible, low-cost, and easy-processing paper-based humidity sensor for sleep respiratory monitoring. A paper humidity sensing model was established and sensors under different design parameters were processed and tested, achieving high sensitivity of 5.45 k\u03a9\/%RH and good repeatability with a matching rate of over 85.7%. Furthermore, the sensor patch with a dual-channel 3D structure was designed to distinguish between oral and nasal breathing from origin signals proved in the simulated breathing signal monitoring test. The sensor patch was applied in the sleep respiratory monitoring of a healthy volunteer and an obstruct sleep apnea patient, demonstrating its ability to distinguish between different respiratory patterns as well as various breathing modes.<\/jats:p>","DOI":"10.3390\/ma15186447","type":"journal-article","created":{"date-parts":[[2022,9,19]],"date-time":"2022-09-19T02:06:50Z","timestamp":1663553210000},"page":"6447","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Paper-Based Humidity Sensor for Respiratory Monitoring"],"prefix":"10.3390","volume":"15","author":[{"given":"Xiaoxiao","family":"Ma","sequence":"first","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Shaoxing","family":"Zhang","sequence":"additional","affiliation":[{"name":"Department of Otolaryngology-Head and Neck Surgery, Peking University Third Hospital, Beijing 100191, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Peikai","family":"Zou","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruya","family":"Li","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yubo","family":"Fan","sequence":"additional","affiliation":[{"name":"Key Laboratory for Biomechanics and Mechanobiology of Ministry of Education, Beijing Advanced Innovation Center for Biomedical Engineering, School of Biological Science and Medical Engineering, Beihang University, Beijing 100083, China"},{"name":"School of Engineering Medicine, Beihang University, Beijing 100083, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,9,16]]},"reference":[{"key":"ref_1","first-page":"887","article-title":"Physiology of respiration","volume":"40","author":"Comroe","year":"1965","journal-title":"Acad. 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