{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,10,24]],"date-time":"2026-10-24T11:54:22Z","timestamp":1792842862051,"version":"4.5.0"},"reference-count":62,"publisher":"MDPI AG","issue":"19","license":[{"start":{"date-parts":[[2022,10,1]],"date-time":"2022-10-01T00:00:00Z","timestamp":1664582400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004281","name":"National Science Centre (Poland)","doi-asserted-by":"publisher","award":["2018\/31\/B\/NZ7\/03083"],"award-info":[{"award-number":["2018\/31\/B\/NZ7\/03083"]}],"id":[{"id":"10.13039\/501100004281","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Complexes of chlorogenic acid (5-CQA) with copper(II) and iron(III) were synthesized in a solid state and examined by means of FT-IR, thermogravimetric, and elemental analyses. The molar stoichiometric ratios of metal:ligand for the solid forms of the complexes were established as Cu(II):L = 1:2 and Fe(III):L = 2:3 (L: 5-CQA), with the possible coordination through the carboxylate group and the hydroxyl group from the catechol moiety. In an aqueous solution at pH = 7.4, the composition of the complexes was Cu(II):L = 1:1, and Fe(III):L = 1:1 and 1:2. The Cu(II) and Fe(III) complexes with 5-CQA showed lower antioxidant properties, as estimated by the spectrophotometric methods with DPPH\u2022, ABTS\u2022+, and HO\u2022 radicals, than the ligand alone, whereas in the lipid peroxidation inhibition assay, the metal complexes revealed a higher antioxidant activity than 5-CQA. Cu(II) 5-CQA showed the highest pro-oxidant activity in the Trolox oxidation assays compared to the other studied compounds. The lipophilic parameters of the compounds were estimated using the HPLC method. 5-CQA and its complexes with Fe(III) and Cu(II) were not toxic to HaCaT cells in a tested concentration range of 0.15\u20131000 nM after a 24 h incubation time.<\/jats:p>","DOI":"10.3390\/ma15196832","type":"journal-article","created":{"date-parts":[[2022,10,9]],"date-time":"2022-10-09T01:43:11Z","timestamp":1665279791000},"page":"6832","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":27,"title":["Fe(III) and Cu(II) Complexes of Chlorogenic Acid: Spectroscopic, Thermal, Anti-\/Pro-Oxidant, and Cytotoxic Studies"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-0839-9891","authenticated-orcid":false,"given":"Monika","family":"Kalinowska","sequence":"first","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3441-4458","authenticated-orcid":false,"given":"Kamila","family":"Gryko","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5039-9537","authenticated-orcid":false,"given":"Ewelina","family":"Go\u0142\u0119biewska","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4442-6348","authenticated-orcid":false,"given":"Grzegorz","family":"\u015awiderski","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1960-1071","authenticated-orcid":false,"given":"Hanna","family":"Lewandowska","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8835-2462","authenticated-orcid":false,"given":"Marek","family":"Pruszy\u0144ski","sequence":"additional","affiliation":[{"name":"Institute of Nuclear Chemistry and Technology, 16 Dorodna Street, 03-195 Warsaw, Poland"},{"name":"NOMATEN Centre of Excellence, National Centre of Nuclear Research, 7 Andrzeja Soltana Street, 05-400 Otwock, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ma\u0142gorzata","family":"Zawadzka","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Maciej","family":"Koz\u0142owski","sequence":"additional","affiliation":[{"name":"Department of Chemistry, Biology and Biotechnology, Institute of Environmental Engineering and Energetics, Faculty of Civil Engineering and Environmental Sciences, Bia\u0142ystok University of Technology, Wiejska 45E Street, 15-351 Bialystok, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-4956-300X","authenticated-orcid":false,"given":"Justyna","family":"Sienkiewicz-Gromiuk","sequence":"additional","affiliation":[{"name":"Department of General and Coordination Chemistry and Crystallography, Institute of Chemical Sciences, Faculty of Chemistry, Maria Curie-Sklodowska University, Maria Curie-Sklodowska Sq. 2, 20-031 Lublin, 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