{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,6,10]],"date-time":"2026-06-10T20:02:53Z","timestamp":1781121773995,"version":"3.54.1"},"reference-count":95,"publisher":"MDPI AG","issue":"22","license":[{"start":{"date-parts":[[2022,11,14]],"date-time":"2022-11-14T00:00:00Z","timestamp":1668384000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"European Union\u2019s Horizon 2020 research and innovation program under the Marie Skodowska-Curie","award":["713750"],"award-info":[{"award-number":["713750"]}]},{"name":"European Union\u2019s Horizon 2020 research and innovation program under the Marie Skodowska-Curie","award":["ANR- 11-IDEX-0001-02"],"award-info":[{"award-number":["ANR- 11-IDEX-0001-02"]}]},{"name":"Regional Council of Provence- Alpes-C\u00f4te d\u2019Azur and with the financial support of the A*MIDEX","award":["713750"],"award-info":[{"award-number":["713750"]}]},{"name":"Regional Council of Provence- Alpes-C\u00f4te d\u2019Azur and with the financial support of the A*MIDEX","award":["ANR- 11-IDEX-0001-02"],"award-info":[{"award-number":["ANR- 11-IDEX-0001-02"]}]},{"name":"French National Research Agency (ANR)","award":["713750"],"award-info":[{"award-number":["713750"]}]},{"name":"French National Research Agency (ANR)","award":["ANR- 11-IDEX-0001-02"],"award-info":[{"award-number":["ANR- 11-IDEX-0001-02"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Although multiple structural, mechanical, and molecular factors are definitely involved in osteoporosis, the assessment of subregional bone mineral density remains the most commonly used diagnostic index. In this study, we characterized bone quality in the femoral neck of one osteoporotic patients as compared to an age-matched control subject, and so used a multiscale and multimodal approach including X-ray computed microtomography at different spatial resolutions (pixel size: 51.0, 4.95 and 0.9 \u00b5m), microindentation and Fourier transform infrared spectroscopy. Our results showed abnormalities in the osteocytes lacunae volume (358.08 \u00b1 165.00 for the osteoporotic sample vs. 287.10 \u00b1 160.00 for the control), whereas a statistical difference was found neither for shape nor for density. The osteoporotic femoral head and great trochanter reported reduced elastic modulus (Es) and hardness (H) compared to the control reference (\u221248% (p &lt; 0.0001) and \u221234% (p &lt; 0.0001), respectively for Es and H in the femoral head and \u221229% (p &lt; 0.01) and \u221222% (p &lt; 0.05), respectively for Es and H in the great trochanter), whereas the corresponding values in the femoral neck were in the same range. The spectral analysis could distinguish neither subregional differences in the osteoporotic sample nor between the osteoporotic and healthy samples. Although, infrared spectroscopic measurements were comparable among subregions, and so regardless of the bone osteoporotic status, the trabecular mechanical properties were comparable only in the femoral neck. These results illustrate that bone remodeling in osteoporosis is a non-uniform process with different rates in different bone anatomical regions, hence showing the interest of a clear analysis of the bone microarchitecture in the case of patients\u2019 osteoporotic evaluation.<\/jats:p>","DOI":"10.3390\/ma15228048","type":"journal-article","created":{"date-parts":[[2022,11,15]],"date-time":"2022-11-15T02:32:16Z","timestamp":1668479536000},"page":"8048","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Multiscale Femoral Neck Imaging and Multimodal Trabeculae Quality Characterization in an Osteoporotic Bone Sample"],"prefix":"10.3390","volume":"15","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-2818-7500","authenticated-orcid":false,"given":"Enrico","family":"Soldati","sequence":"first","affiliation":[{"name":"Aix Marseille University, CNRS, IUSTI, 13453 Marseille, France"},{"name":"Aix Marseille University, CNRS, CRMBM, 13385 Marseille, France"},{"name":"Aix Marseille University, CNRS, ISM, 13288 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Flavy","family":"Roseren","sequence":"additional","affiliation":[{"name":"Aix Marseille University, CNRS, ISM, 13288 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daphne","family":"Guenoun","sequence":"additional","affiliation":[{"name":"Aix Marseille University, CNRS, ISM, 13288 Marseille, France"},{"name":"Aix Marseille University, APHM, CNRS, ISM, Sainte Marguerite Hospital, Institute for Locomotion, Department of Radiology, 13274 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2416-3464","authenticated-orcid":false,"given":"Lucia","family":"Mancini","sequence":"additional","affiliation":[{"name":"Elettra-Sincrotrone Trieste S.C.p.A, SS 14\u2013km 1535 in Area Science Park, Basovizza, 34149 Trieste, Italy"},{"name":"Slovenian National Building and Civil Engineering Institute, Dimi\u010deva ulica 12, 1000 Ljubljana, Slovenia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Emilio","family":"Catelli","sequence":"additional","affiliation":[{"name":"University of Bologna, Department of Chemistry \u201cG. Ciamician\u201d, Ravenna Campus, Via Guaccimanni, 42, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Silvia","family":"Prati","sequence":"additional","affiliation":[{"name":"University of Bologna, Department of Chemistry \u201cG. Ciamician\u201d, Ravenna Campus, Via Guaccimanni, 42, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Giorgia","family":"Sciutto","sequence":"additional","affiliation":[{"name":"University of Bologna, Department of Chemistry \u201cG. Ciamician\u201d, Ravenna Campus, Via Guaccimanni, 42, 48121 Ravenna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jerome","family":"Vicente","sequence":"additional","affiliation":[{"name":"Aix Marseille University, CNRS, IUSTI, 13453 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1426-6400","authenticated-orcid":false,"given":"Stefano","family":"Iotti","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Bologna, Department of Pharmacy and Biotechnology (FaBit), Via Zamboni 33, 40126 Bologna, Italy"},{"name":"National Institute of Biostructures and Biosystems, Viale delle Medaglie d\u2019Oro 305, 00136 Roma, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"David","family":"Bendahan","sequence":"additional","affiliation":[{"name":"Aix Marseille University, CNRS, CRMBM, 13385 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1077-0098","authenticated-orcid":false,"given":"Emil","family":"Malucelli","sequence":"additional","affiliation":[{"name":"Universit\u00e0 di Bologna, Department of Pharmacy and Biotechnology (FaBit), Via Zamboni 33, 40126 Bologna, Italy"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5283-3504","authenticated-orcid":false,"given":"Martine","family":"Pithioux","sequence":"additional","affiliation":[{"name":"Aix Marseille University, CNRS, ISM, 13288 Marseille, France"},{"name":"Aix Marseille University, APHM, CNRS, ISM, Sainte-Marguerite Hospital, Institute for Locomotion, Department of Orthopaedics and Traumatology, 13274 Marseille, France"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2022,11,14]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"151422","DOI":"10.1016\/j.aanat.2019.151422","article-title":"The osteocyte: A multifunctional cell within the bone","volume":"227","author":"Tresguerres","year":"2020","journal-title":"Ann. 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