{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,7,31]],"date-time":"2026-07-31T22:28:24Z","timestamp":1785536904709,"version":"3.56.0"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T00:00:00Z","timestamp":1674086400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["52075421"],"award-info":[{"award-number":["52075421"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["2020B1515130002"],"award-info":[{"award-number":["2020B1515130002"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100001809","name":"National Natural Science Foundation of China","doi-asserted-by":"publisher","award":["JH-HT20220101"],"award-info":[{"award-number":["JH-HT20220101"]}],"id":[{"id":"10.13039\/501100001809","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Guangdong Basic Applied Basic Research Foundation","award":["52075421"],"award-info":[{"award-number":["52075421"]}]},{"name":"Guangdong Basic Applied Basic Research Foundation","award":["2020B1515130002"],"award-info":[{"award-number":["2020B1515130002"]}]},{"name":"Guangdong Basic Applied Basic Research Foundation","award":["JH-HT20220101"],"award-info":[{"award-number":["JH-HT20220101"]}]},{"name":"Ji Hua Laboratory Project","award":["52075421"],"award-info":[{"award-number":["52075421"]}]},{"name":"Ji Hua Laboratory Project","award":["2020B1515130002"],"award-info":[{"award-number":["2020B1515130002"]}]},{"name":"Ji Hua Laboratory Project","award":["JH-HT20220101"],"award-info":[{"award-number":["JH-HT20220101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Strong and tough \u03b2-TCP\/PCL composite scaffolds with interconnected porosity were developed by combining digital light processing and vacuum infiltration. The composite scaffolds were comprised of pure \u03b2-TCP, \u03b2-TCP matrix composite and PCL matrix composite. The porous \u03b2-TCP\/PCL composite scaffolds showed remarkable mechanical advantages compared with ceramic scaffolds with the same macroscopic pore structure (dense scaffolds). The composite scaffolds exhibited a significant increase in strain energy density and fracture energy density, though with similar compressive and flexural strengths. Moreover, the composite scaffolds had a much higher Weibull modulus and longer fatigue life than the dense scaffolds. It was revealed that the composite scaffolds with interconnected porosity possess comprehensive mechanical properties (high strength, excellent toughness, significant reliability and fatigue resistance), which suggests that they could replace the pure ceramic scaffolds for degradable bone substitutes, especially in complex stress environments.<\/jats:p>","DOI":"10.3390\/ma16030947","type":"journal-article","created":{"date-parts":[[2023,1,19]],"date-time":"2023-01-19T06:22:10Z","timestamp":1674109330000},"page":"947","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":9,"title":["Development of Strong and Tough \u03b2-TCP\/PCL Composite Scaffolds with Interconnected Porosity by Digital Light Processing and Partial Infiltration"],"prefix":"10.3390","volume":"16","author":[{"given":"Yanlong","family":"Wu","sequence":"first","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China"},{"name":"Ji Hua Laboratory, Foshan 528200, China"},{"name":"School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruomeng","family":"Chen","sequence":"additional","affiliation":[{"name":"Key Lab of Intelligent Equipment Digital Design and Process Simulation, Tangshan College, Tangshan 063000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Xu","family":"Chen","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China"},{"name":"Ji Hua Laboratory, Foshan 528200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yongqiang","family":"Yang","sequence":"additional","affiliation":[{"name":"School of Mechanical and Automotive Engineering, South China University of Technology, Guangzhou 510640, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jian","family":"Qiao","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yaxiong","family":"Liu","sequence":"additional","affiliation":[{"name":"School of Mechatronic Engineering and Automation, Foshan University, Foshan 528000, China"},{"name":"Ji Hua Laboratory, Foshan 528200, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,19]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"267","DOI":"10.1208\/s12249-022-02419-1","article-title":"Biomaterials for Tissue Engineering Applications and Current Updates in the Field: A Comprehensive Review","volume":"23","author":"Eldeeb","year":"2022","journal-title":"AAPS PharmSciTech"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"104693","DOI":"10.1016\/j.mtcomm.2022.104693","article-title":"High strength bioinspired calcium phosphate-based material for bone repair applications","volume":"33","author":"Mussatto","year":"2022","journal-title":"Mater. Today Commun."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"100473","DOI":"10.1016\/j.mtbio.2022.100473","article-title":"Recent advances on bioactive baghdadite ceramic for bone tissue engineering applications: 20 years of research and innovation (a review)","volume":"17","author":"Sadeghzade","year":"2022","journal-title":"Mater. Today Bio"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"045008","DOI":"10.1088\/1758-5090\/aa90ed","article-title":"Creating hierarchical porosity hydroxyapatite scaffolds with osteoinduction by three-dimensional printing and microwave sintering","volume":"9","author":"Pei","year":"2017","journal-title":"Biofabrication"},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Gonzalez-Henriquez, C.M., Rodriguez-Umanzor, F.E., Acuna-Ruiz, N.F., Vera-Rojas, G.E., Terraza-Inostroza, C., Cohn-Inostroza, N.A., Utrera, A., Sarabia-Vallejos, M.A., and Rodriguez-Hernandez, J. (2022). Fabrication and Testing of Multi-Hierarchical Porous Scaffolds Designed for Bone Regeneration via Additive Manufacturing Processes. Polymers, 14.","DOI":"10.3390\/polym14194041"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"133388","DOI":"10.1016\/j.matlet.2022.133388","article-title":"In vitro and in vivo evaluation of hierarchical porous structure for osteogenic differentiation promotion","volume":"330","author":"Wang","year":"2023","journal-title":"Mater. Lett."},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"3351","DOI":"10.1016\/j.jeurceramsoc.2022.02.039","article-title":"A review of 3D printed porous ceramics","volume":"42","author":"Zhang","year":"2022","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"109895","DOI":"10.1016\/j.msec.2019.109895","article-title":"Mechanical properties of bioactive glasses, ceramics, glass-ceramics and composites: State-of-the-art review and future challenges","volume":"104","author":"Kaur","year":"2019","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"110856","DOI":"10.1016\/j.matdes.2022.110856","article-title":"Effect of polycaprolactone impregnation on the properties of calcium silicate scaffolds fabricated by 3D printing","volume":"220","author":"Liu","year":"2022","journal-title":"Mater. Des."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"16188","DOI":"10.1016\/j.ceramint.2019.05.140","article-title":"\u03b2-Tricalcium phosphate\/\u0511-polycaprolactone composite scaffolds with a controllable gradient: Fabrication and characterization","volume":"45","author":"Wu","year":"2019","journal-title":"Ceram. Int."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"23","DOI":"10.1016\/j.actbio.2020.06.022","article-title":"\u03b2-tricalcium phosphate for bone substitution: Synthesis and properties","volume":"113","author":"Bohner","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"366","DOI":"10.1021\/acs.biomac.9b01272","article-title":"Additive Manufacturing of Bioactive Poly(trimethylene carbonate)\/beta-Tricalcium Phosphate Composites for Bone Regeneration","volume":"21","author":"Dienel","year":"2020","journal-title":"Biomacromolecules"},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"22","DOI":"10.1016\/j.actbio.2019.12.034","article-title":"The role of calcium phosphate surface structure in osteogenesis and the mechanisms involved","volume":"106","author":"Xiao","year":"2020","journal-title":"Acta Biomater."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"68","DOI":"10.1016\/j.jmbbm.2016.04.035","article-title":"Effects of poly (epsilon-caprolactone) coating on the properties of three-dimensional printed porous structures","volume":"70","author":"Zhou","year":"2017","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/j.jmbbm.2018.04.022","article-title":"Enhancing the mechanical and in vitro performance of robocast bioglass scaffolds by polymeric coatings: Effect of polymer composition","volume":"84","author":"Motealleh","year":"2018","journal-title":"J. Mech. Behav. Biomed. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.jconrel.2022.09.022","article-title":"Performance comparison of PLA- and PLGA-coated porous bioceramic scaffolds: Mechanical, biodegradability, bioactivity, delivery and biocompatibility assessments","volume":"351","author":"Maadani","year":"2022","journal-title":"J. Control. Release"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"780","DOI":"10.1016\/j.msec.2016.07.011","article-title":"Development of PLGA-coated beta-TCP scaffolds containing VEGF for bone tissue engineering","volume":"69","author":"Khojasteh","year":"2016","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"1569","DOI":"10.1016\/j.eurpolymj.2011.05.004","article-title":"Enhanced mechanical performance and biological evaluation of a PLGA coated beta-TCP composite scaffold for load-bearing applications","volume":"47","author":"Kang","year":"2011","journal-title":"Eur. Polym. J."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"110176","DOI":"10.1016\/j.msec.2019.110176","article-title":"In vitro evaluation of diopside\/baghdadite bioceramic scaffolds modified by polycaprolactone fumarate polymer coating","volume":"106","author":"Sadeghzade","year":"2020","journal-title":"Mater. Sci. Eng. C Mater. Biol. Appl."},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"4361","DOI":"10.1016\/j.actbio.2010.05.024","article-title":"Improving the compressive strength of bioceramic robocast scaffolds by polymer infiltration","volume":"6","author":"Perera","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"111","DOI":"10.1016\/j.jnoncrysol.2015.02.025","article-title":"Improving mechanical properties of 13\u201393 bioactive glass robocast scaffold by poly (lactic acid) and poly (\u03b5-caprolactone) melt infiltration","volume":"432","author":"Eqtesadi","year":"2016","journal-title":"J. Non-Cryst. Solids"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"4001","DOI":"10.3390\/ma7054001","article-title":"Effect of Polymer Infiltration on the Flexural Behavior of beta-Tricalcium Phosphate Robocast Scaffolds","volume":"7","author":"Pajares","year":"2014","journal-title":"Materials"},{"key":"ref_23","doi-asserted-by":"crossref","unstructured":"Crispim da Silveira, O., Rodrigues, A.M., Montazerian, M., de Lucena Lira, H., Baino, F., and Menezes, R.R. (2021). Al2O3 Preforms Infiltrated with Poly(methyl methacrylate) for Dental Prosthesis Manufacturing. Appl. Sci., 11.","DOI":"10.3390\/app11167583"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"025005","DOI":"10.1088\/1758-5090\/aa6a62","article-title":"Fabrication of beta-tricalcium phosphate composite ceramic sphere-based scaffolds with hierarchical pore structure for bone regeneration","volume":"9","author":"He","year":"2017","journal-title":"Biofabrication"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"19572","DOI":"10.1016\/j.ceramint.2019.06.175","article-title":"Novel strategy for toughening robocast bioceramic scaffolds using polymeric cores","volume":"45","author":"Paredes","year":"2019","journal-title":"Ceram. Int."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"10163","DOI":"10.1016\/j.ceramint.2020.12.165","article-title":"Using ductile cores for enhancing the mechanical performance of hollow strut \u03b2-TCP scaffolds fabricated by digital light processing","volume":"47","author":"Paredes","year":"2021","journal-title":"Ceram. Int."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"17726","DOI":"10.1016\/j.ceramint.2021.03.093","article-title":"Co-continuous calcium phosphate\/polycaprolactone composite bone scaffolds fabricated by digital light processing and polymer melt suction","volume":"47","author":"Paredes","year":"2021","journal-title":"Ceram. Int."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"93","DOI":"10.1586\/17434440.2015.958075","article-title":"Toughening and functionalization of bioactive ceramic and glass bone scaffolds by biopolymer coatings and infiltration: A review of the last 5 years","volume":"12","author":"Philippart","year":"2015","journal-title":"Expert Rev. Med. Devices"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"4323","DOI":"10.1016\/j.jeurceramsoc.2020.05.013","article-title":"Effect of graphite particles as additive on the curing behaviour of \u03b2-tricalcium phosphate suspensions and scaffold fabrication by digital light processing","volume":"40","author":"Wu","year":"2020","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"101","DOI":"10.1016\/j.jiec.2017.06.033","article-title":"Surface immobilization of biphasic calcium phosphate nanoparticles on 3D printed poly(caprolactone) scaffolds enhances osteogenesis and bone tissue regeneration","volume":"55","author":"Shim","year":"2017","journal-title":"J. Ind. Eng. Chem."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"1043","DOI":"10.1016\/j.jmrt.2019.10.035","article-title":"Preparation and characterization of sodium silicate impregnated Chinese fir wood with high strength, water resistance, flame retardant and smoke suppression","volume":"9","author":"Li","year":"2020","journal-title":"J. Mater. Res. Technol."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"5144","DOI":"10.1038\/s41467-021-25463-0","article-title":"Additive manufacturing of strong silica sand structures enabled by polyethyleneimine binder","volume":"12","author":"Gilmer","year":"2021","journal-title":"Nat. Commun."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"3985","DOI":"10.1016\/j.jeurceramsoc.2015.06.021","article-title":"Influence of sintering temperature on the mechanical properties of \u03f5-PCL-impregnated 45S5 bioglass-derived scaffolds fabricated by robocasting","volume":"35","author":"Eqtesadi","year":"2015","journal-title":"J. Eur. Ceram. Soc."},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"110531","DOI":"10.1016\/j.matdes.2022.110531","article-title":"Mechanical performance of PEEK-Ti6Al4V interpenetrating phase composites fabricated by powder bed fusion and vacuum infiltration targeting large and load-bearing implants","volume":"215","author":"Chen","year":"2022","journal-title":"Mater. Des."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/3\/947\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T18:10:28Z","timestamp":1760119828000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/3\/947"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,1,19]]},"references-count":34,"journal-issue":{"issue":"3","published-online":{"date-parts":[[2023,2]]}},"alternative-id":["ma16030947"],"URL":"https:\/\/doi.org\/10.3390\/ma16030947","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,1,19]]}}}