{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,7]],"date-time":"2026-05-07T21:48:42Z","timestamp":1778190522712,"version":"3.51.4"},"reference-count":34,"publisher":"MDPI AG","issue":"3","license":[{"start":{"date-parts":[[2023,1,25]],"date-time":"2023-01-25T00:00:00Z","timestamp":1674604800000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100004586","name":"Foundation Carlos Chagas Filho Research Support of the State of Rio de Janeiro (FAPERJ)","doi-asserted-by":"publisher","award":["201.401\/2022"],"award-info":[{"award-number":["201.401\/2022"]}],"id":[{"id":"10.13039\/501100004586","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The aim of the present study is to compare the biphasic calcium phosphate (BCP) using two different forms\u2014(1) granules and (2) paste\u2014in human maxillary sinus bone reconstruction as a split-mouth study using histomorphometric and immunolabeling for osteocalcin. Ten patients with bilateral maxillary posterior partial edentulism were selected in order to reconstruct bone height. They were divided into two groups: BCPG and BCP-P. After six months of bone healing, biopsies were harvested to assess the new bone formation and immunostaining for osteocalcin. The BCP g group had the following results: mean of bone formation in pristine bone 49.4 \u00b1 21.6%, intermediate 49.4 \u00b1 16.2%, and apical 55.3 \u00b1 21.4%. The group BCP-P had a mean of 41.9 \u00b1 17.3% in the pristine bone region, 37.5 \u00b1 7.8% for intermediate, and 39.0 \u00b1 13.5% for apical. The osteocalcin immunolabeling was high for both groups, demonstrating bone calcification. Thus, the two biomaterials present suitable results for the placement of dental implants.<\/jats:p>","DOI":"10.3390\/ma16031059","type":"journal-article","created":{"date-parts":[[2023,1,26]],"date-time":"2023-01-26T01:30:30Z","timestamp":1674696630000},"page":"1059","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Clinical Assessment of Biphasic Calcium Phosphate in Granules and Paste Forms in Human Maxillary Sinus Bone Augmentation: A Randomized, Split-Mouth Clinical Trial"],"prefix":"10.3390","volume":"16","author":[{"given":"Jo\u00e3o Paulo","family":"Bonardi","sequence":"first","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2509-8633","authenticated-orcid":false,"given":"Rodrigo dos Santos","family":"Pereira","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, University of Grande Rio-UNIGRANRIO, Rio de Janeiro 25071-202, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5775-0222","authenticated-orcid":false,"given":"Carlos F.","family":"Mour\u00e3o","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Division of Dental Research Administration, Tufts University School of Dental Medicine, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Bruno","family":"Coelho Mendes","sequence":"additional","affiliation":[{"name":"Department of Oral & Maxillofacial Surgery, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0751-4894","authenticated-orcid":false,"given":"Adam","family":"Lowenstein","sequence":"additional","affiliation":[{"name":"Department of Periodontology, Division of Dental Research Administration, Tufts University School of Dental Medicine, Boston, MA 02111, USA"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Pietro","family":"Montemezzi","sequence":"additional","affiliation":[{"name":"Department of Dentistry, San Raffaele Hospital, 20132 Milan, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Flavio","family":"Giubilato","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Roberta","family":"Okamoto","sequence":"additional","affiliation":[{"name":"Department of Human Anatomy, Aracatuba School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Eduardo","family":"Hochuli-Vieira","sequence":"additional","affiliation":[{"name":"Department of Diagnostic and Surgery, Araraquara School of Dentistry, Sao Paulo State University, Sao Paulo 16066-840, Brazil"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,1,25]]},"reference":[{"key":"ref_1","unstructured":"Mich, C.E. 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