{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:57:53Z","timestamp":1760147873200,"version":"build-2065373602"},"reference-count":268,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T00:00:00Z","timestamp":1678406400000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001870","name":"Foundation for Polish Science","doi-asserted-by":"publisher","award":["POIR.04.04.00-00-16D7\/18"],"award-info":[{"award-number":["POIR.04.04.00-00-16D7\/18"]}],"id":[{"id":"10.13039\/501100001870","id-type":"DOI","asserted-by":"publisher"}]},{"name":"project APVV-17-0373","award":["POIR.04.04.00-00-16D7\/18"],"award-info":[{"award-number":["POIR.04.04.00-00-16D7\/18"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Conventional intake of drugs and active substances is most often based on oral intake of an appropriate dose to achieve the desired effect in the affected area or source of pain. In this case, controlling their distribution in the body is difficult, as the substance also reaches other tissues. This phenomenon results in the occurrence of side effects and the need to increase the concentration of the therapeutic substance to ensure it has the desired effect. The scientific field of tissue engineering proposes a solution to this problem, which creates the possibility of designing intelligent systems for delivering active substances precisely to the site of disease conversion. The following review discusses significant current research strategies as well as examples of polymeric and composite carriers for protein and non-protein biomolecules designed for bone tissue regeneration.<\/jats:p>","DOI":"10.3390\/ma16062235","type":"journal-article","created":{"date-parts":[[2023,3,10]],"date-time":"2023-03-10T05:02:17Z","timestamp":1678424537000},"page":"2235","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":3,"title":["Polymeric and Composite Carriers of Protein and Non-Protein Biomolecules for Application in Bone Tissue Engineering"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8570-3594","authenticated-orcid":false,"given":"Dagmara","family":"S\u0142ota","sequence":"first","affiliation":[{"name":"Department of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Paw\u0142a II Av., 31-864 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7970-3478","authenticated-orcid":false,"given":"Karina","family":"Pi\u0119tak","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Paw\u0142a II Av., 31-864 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-2003-9052","authenticated-orcid":false,"given":"Josef","family":"Jampilek","sequence":"additional","affiliation":[{"name":"Department of Analytical Chemistry, Faculty of Natural Sciences, Comenius University, Ilkovicova 6, 842 15 Bratislava, Slovakia"},{"name":"Department of Chemical Biology, Faculty of Science, Palacky University Olomouc, Slechtitelu 27, 783 71 Olomouc, Czech Republic"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-0005-6146","authenticated-orcid":false,"given":"Agnieszka","family":"Sobczak-Kupiec","sequence":"additional","affiliation":[{"name":"Department of Materials Science, Faculty of Materials Engineering and Physics, Cracow University of Technology, 37 Jana Paw\u0142a II Av., 31-864 Krakow, Poland"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Trucillo, P. 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