{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T01:59:50Z","timestamp":1760147990037,"version":"build-2065373602"},"reference-count":70,"publisher":"MDPI AG","issue":"7","license":[{"start":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T00:00:00Z","timestamp":1679529600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"Ministry of Research, Innovation and Digitalization CNCS-UEFISCDI","doi-asserted-by":"publisher","award":["PN-III-P1-1.1-PD-2021-0326"],"award-info":[{"award-number":["PN-III-P1-1.1-PD-2021-0326"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Lesions of the articular cartilage are frequent in all age populations and lead to functional impairment. Multiple surgical techniques have failed to provide an effective method for cartilage repair. The aim of our research was to evaluate the effect of two different compression forces on three types of cartilage repair using finite element analysis (FEA). Initially, an in vivo study was performed on sheep. The in vivo study was prepared as following: Case 0\u2014control group, without cartilage lesion; Case 1\u2014cartilage lesion treated with macro-porous collagen implants; Case 2\u2014cartilage lesion treated with collagen implants impregnated with bone marrow concentrate (BMC); Case 3\u2014cartilage lesion treated with collagen implants impregnated with adipose-derived stem cells (ASC). Using the computed tomography (CT) data, virtual femur-cartilage-tibia joints were created for each Case. The study showed better results in bone changes when using porous collagen implants impregnated with BMC or ASC stem cells for the treatment of osseocartilaginous defects compared with untreated macro-porous implant. After 7 months postoperative, the presence of un-resorbed collagen influences the von Mises stress distribution, total deformation, and displacement on the Z axis. The BMC treatment was superior to ASC cells in bone tissue morphology, resembling the biomechanics of the control group in all FEA simulations.<\/jats:p>","DOI":"10.3390\/ma16072546","type":"journal-article","created":{"date-parts":[[2023,3,23]],"date-time":"2023-03-23T02:35:26Z","timestamp":1679538926000},"page":"2546","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Finite Element Analysis of Different Osseocartilaginous Reconstruction Techniques in Animal Model Knees"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-3022-4457","authenticated-orcid":false,"given":"Cosmin","family":"Cosma","sequence":"first","affiliation":[{"name":"Department of Manufacturing Engineering, Technical University of Cluj-Napoca, 400641 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9046-9432","authenticated-orcid":false,"given":"Dragos","family":"Apostu","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400132 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5622-0393","authenticated-orcid":false,"given":"Cristian","family":"Vilau","sequence":"additional","affiliation":[{"name":"Department of Material Resistance, Technical University of Cluj-Napoca, 400641 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Alexandru","family":"Popan","sequence":"additional","affiliation":[{"name":"Department of Manufacturing Engineering, Technical University of Cluj-Napoca, 400641 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8094-8963","authenticated-orcid":false,"given":"Daniel","family":"Oltean-Dan","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400132 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Nicolae","family":"Balc","sequence":"additional","affiliation":[{"name":"Department of Manufacturing Engineering, Technical University of Cluj-Napoca, 400641 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Gheorghe","family":"Tomoaie","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400132 Cluj-Napoca, Romania"},{"name":"Academy of Romanian Scientists, 050044 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Horea","family":"Benea","sequence":"additional","affiliation":[{"name":"Department of Orthopedics and Traumatology, Iuliu Ha\u0163ieganu University of Medicine and Pharmacy, 400132 Cluj-Napoca, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,3,23]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"794","DOI":"10.1016\/j.jbiomech.2010.12.026","article-title":"Finite element simulations of a focal knee resurfacing implant applied to localized cartilage defects in a sheep model","volume":"44","author":"Manda","year":"2011","journal-title":"J. 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