{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,4]],"date-time":"2026-09-04T04:14:28Z","timestamp":1788495268374,"version":"build-2803163510"},"reference-count":61,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2023,7,22]],"date-time":"2023-07-22T00:00:00Z","timestamp":1689984000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100012190","name":"Ministry of Science and Higher Education of the Russian Federation","doi-asserted-by":"publisher","award":["075-15-2022-315"],"award-info":[{"award-number":["075-15-2022-315"]}],"id":[{"id":"10.13039\/501100012190","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>With the help of laser ablation, a technology for obtaining nanosized crystalline selenium particles (SeNPs) has been created. The SeNPs do not exhibit significant toxic properties, in contrast to molecular selenium compounds. The administration of SeNPs can significantly increase the viabilities of SH-SY5Y and PCMF cells after radiation exposure. The introduction of such nanoparticles into the animal body protects proteins and DNA from radiation-induced damage. The number of chromosomal breaks and oxidized proteins decreases in irradiated mice treated with SeNPs. Using hematological tests, it was found that a decrease in radiation-induced leukopenia and thrombocytopenia is observed when selenium nanoparticles are injected into mice before exposure to ionizing radiation. The administration of SeNPs to animals 5 h before radiation exposure in sublethal and lethal doses significantly increases their survival rate. The modification dose factor for animal survival was 1.2. It has been shown that the introduction of selenium nanoparticles significantly normalizes gene expression in the cells of the red bone marrow of mice after exposure to ionizing radiation. Thus, it has been demonstrated that SeNPs are a new gene-protective and radioprotective agent that can significantly reduce the harmful effects of ionizing radiation.<\/jats:p>","DOI":"10.3390\/ma16145164","type":"journal-article","created":{"date-parts":[[2023,7,24]],"date-time":"2023-07-24T01:15:45Z","timestamp":1690161345000},"page":"5164","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":14,"title":["Laser Ablation-Generated Crystalline Selenium Nanoparticles Prevent Damage of DNA and Proteins Induced by Reactive Oxygen Species and Protect Mice against Injuries Caused by Radiation-Induced Oxidative Stress"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-8814-6906","authenticated-orcid":false,"given":"Sergey V.","family":"Gudkov","sequence":"first","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, 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St., 119991 Moscow, Russia"},{"name":"Department of Fundamental Sciences, Bauman Moscow State Technical University, 2-nd Baumanskaya Str. 5, 105005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6893-1739","authenticated-orcid":false,"given":"Nikolay F.","family":"Bunkin","sequence":"additional","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia"},{"name":"Department of Fundamental Sciences, Bauman Moscow State Technical University, 2-nd Baumanskaya Str. 5, 105005 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mikhail A.","family":"Sevostyanov","sequence":"additional","affiliation":[{"name":"Russian Scientific-Research Institute of Phytopathology of Russian Academy of Sciences, 143050 Big Vyazemy, Russia"},{"name":"A. A. Baikov Institute of Metallurgy and Materials Science (IMET RAS) of the Russian Academy of Sciences, Leninsky Prospect, 49, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4907-951X","authenticated-orcid":false,"given":"Alexey G.","family":"Kolmakov","sequence":"additional","affiliation":[{"name":"A. A. Baikov Institute of Metallurgy and Materials Science (IMET RAS) of the Russian Academy of Sciences, Leninsky Prospect, 49, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8635-0719","authenticated-orcid":false,"given":"Mikhail A.","family":"Kaplan","sequence":"additional","affiliation":[{"name":"A. A. Baikov Institute of Metallurgy and Materials Science (IMET RAS) of the Russian Academy of Sciences, Leninsky Prospect, 49, 119334 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5362-4269","authenticated-orcid":false,"given":"Mars G.","family":"Sharapov","sequence":"additional","affiliation":[{"name":"Institute of Cell Biophysics of the Russian Academy of Sciences, Federal Research Center \u201cPush-chino Scientific Center for Biological Research of the Russian Academy of Sciences\u201d, Institutskaya St., 3, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vladimir E.","family":"Ivanov","sequence":"additional","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia"},{"name":"Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Vadim I.","family":"Bruskov","sequence":"additional","affiliation":[{"name":"Institute of Theoretical and Experimental Biophysics of the Russian Academy of Sciences, Institutskaya St. 3, 142290 Pushchino, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery P.","family":"Kalinichenko","sequence":"additional","affiliation":[{"name":"Russian Scientific-Research Institute of Phytopathology of Russian Academy of Sciences, 143050 Big Vyazemy, Russia"},{"name":"Institute of Fertility of Soils of South Russia, 346493 Persianovka, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Kuder O.","family":"Aiyyzhy","sequence":"additional","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Valery V.","family":"Voronov","sequence":"additional","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nuttaporn","family":"Pimpha","sequence":"additional","affiliation":[{"name":"National Nanotechnology Center (NANOTEC), National Science and Technology Development Agency (NSTDA) 111, Phahonyotin Rd, Klong Luang 12120, Thailand"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruibin","family":"Li","sequence":"additional","affiliation":[{"name":"State Key Laboratory of Radiation Medicine and Protection, School for Radiological and Interdisciplinary Sciences (RAD-X), Collaborative Innovation Center of Radiation Medicine of Jiangsu Higher Education Institutions, Suzhou Medical College, Soochow University, Suzhou 215123, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Georgy A.","family":"Shafeev","sequence":"additional","affiliation":[{"name":"Prokhorov General Physics Institute of the Russian Academy of Sciences, 38 Vavilova St., 119991 Moscow, Russia"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,7,22]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","unstructured":"Obrador, E., Salvador, R., Villaescusa, J.I., Soriano, J.M., Estrela, J.M., and Montoro, A. 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