{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,11]],"date-time":"2025-10-11T02:22:57Z","timestamp":1760149377289,"version":"build-2065373602"},"reference-count":52,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T00:00:00Z","timestamp":1691539200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Russian Scientific Fund","award":["22-23-00278"],"award-info":[{"award-number":["22-23-00278"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Surgical operations on the peritoneum are often associated with the formation of adhesions, which can interfere with the normal functioning of the internal organs. The effectiveness of existing barrier materials is relatively low. In this work, the effectiveness of soluble alginate\u2013polyvinylpyrrolidone (PVP-Alg) and non-soluble Ca ion cross-linked (PVP-Alg-Ca) films in preventing these adhesions was evaluated. Experiments in vivo were performed on mice via mechanical injury to the adjacent peritoneum wall and the caecum, followed by the application of PVP-Alg or PVP-Alg-Ca films to the injured area. After 7 days, samples from the peritoneal wall and caecum were analyzed using histology and quantitative polymerase chain reaction (qPCR). It was shown that the expression of genes responsible for adhesion formation in the caecum in the PVP-Alg group was comparable to that in the control group, while in the PVP-Alg-Ca group, it increased by 5\u201310 times. These results were consistent with the histology: in the PVP-Alg group, the adhesions did not form, while in the PVP-Alg-Ca group, the adhesions corresponded to five points on the adhesion scale. Therefore, the formation of intraperitoneal adhesions can be effectively prevented by non-crosslinked, biodegradable PVP-Alg films, whereas cross-linked, not biodegradable PVP-Alg-Ca films cause inflammation and adhesion formation.<\/jats:p>","DOI":"10.3390\/ma16165532","type":"journal-article","created":{"date-parts":[[2023,8,9]],"date-time":"2023-08-09T10:30:48Z","timestamp":1691577048000},"page":"5532","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":2,"title":["Polyvinylpyrrolidone\u2013Alginate Film Barriers for Abdominal Surgery: Anti-Adhesion Effect in Murine Model"],"prefix":"10.3390","volume":"16","author":[{"given":"Anna A.","family":"Forysenkova","sequence":"first","affiliation":[{"name":"Baikov Institute of Metallurgy and Material Science RAS, Leninsky Av., Build. 49, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3923-6304","authenticated-orcid":false,"given":"Mariya V.","family":"Konovalova","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maclay Str., Build. 16\/10b, 117997 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Inna V.","family":"Fadeeva","sequence":"additional","affiliation":[{"name":"Baikov Institute of Metallurgy and Material Science RAS, Leninsky Av., Build. 49, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga S.","family":"Antonova","sequence":"additional","affiliation":[{"name":"Baikov Institute of Metallurgy and Material Science RAS, Leninsky Av., Build. 49, 119334 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga D.","family":"Kotsareva","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maclay Str., Build. 16\/10b, 117997 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Tatiana K.","family":"Slonskaya","sequence":"additional","affiliation":[{"name":"Department of Analytical, Physical and Colloid Chemistry, I.M. Sechenov First Moscow State Medical University, Trubetskaya Str., Build. 8\/2, 119991 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7953-1853","authenticated-orcid":false,"given":"Julietta V.","family":"Rau","sequence":"additional","affiliation":[{"name":"Department of Analytical, Physical and Colloid Chemistry, I.M. Sechenov First Moscow State Medical University, Trubetskaya Str., Build. 8\/2, 119991 Moscow, Russia"},{"name":"Istituto di Struttura della Materia, Consiglio Nazionale delle Ricerche (ISM-CNR), Via del Fosso del Cavaliere, 100, 00133 Rome, Italy"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-5647-9298","authenticated-orcid":false,"given":"Elena V.","family":"Svirshchevskaya","sequence":"additional","affiliation":[{"name":"Shemyakin-Ovchinnikov Institute of Bioorganic Chemistry RAS, Miklukho-Maclay Str., Build. 16\/10b, 117997 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,9]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1993","DOI":"10.1016\/j.jmig.2021.07.002","article-title":"Ultrasound Visceral Slide Assessment to Evaluate for Intra-Abdominal Adhesions in Patients Undergoing Abdominal Surgery\u2014A Systematic Review and Meta-Analysis","volume":"28","author":"Limperg","year":"2021","journal-title":"J. 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