{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,19]],"date-time":"2026-08-19T19:52:20Z","timestamp":1787169140345,"version":"build-2736575974"},"reference-count":49,"publisher":"MDPI AG","issue":"16","license":[{"start":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T00:00:00Z","timestamp":1691625600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"3Mgives"}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The objective of this study was firstly to assess the demineralization inhibitory effect of ion-releasing restorations in enamel adjacent to restoration using a biofilm caries model and secondly to compare the effect to that in a chemical caries model. Fifty-six bovine incisors were filled with either Surefil one (SuO), Cention N (CN) (both ion-releasing materials), Ketac-Molar (GIC) or Powerfill resin composite (RC). The restored teeth were then randomly divided into 2 groups according to the used caries model (biofilm or chemical caries model). The micro-computed tomography (MicroCt) and optical coherence tomography (OCT) outcome measures used to evaluate demineralization inhibition effects were lesion depth, LD and increase in OCT integrated reflectivity, \u0394IR, at five different depths. It was observed that all outcome measures of CN were statistically the same as those of GIC and conversely with those of RC. This was also the case for SuO except for LD, which was statistically the same as RC. When comparing the two caries models, LD of the biofilm model was statistically deeper (p &lt; 0.05) than the chemical model for all four materials. In conclusion, CN and SuO have similar demineralization inhibitory effects as GIC, and the biofilm caries model is more discriminatory in differentiating demineralization inhibitory effects of ion-releasing restorative material.<\/jats:p>","DOI":"10.3390\/ma16165558","type":"journal-article","created":{"date-parts":[[2023,8,10]],"date-time":"2023-08-10T10:52:40Z","timestamp":1691664760000},"page":"5558","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":10,"title":["Inhibition of Caries around Restoration by Ion-Releasing Restorative Materials: An In Vitro Optical Coherence Tomography and Micro-Computed Tomography Evaluation"],"prefix":"10.3390","volume":"16","author":[{"given":"Eman H.","family":"Albelasy","sequence":"first","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Algomhoria Street, Mansoura 35516, Egypt"},{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Ruoqiong","family":"Chen","sequence":"additional","affiliation":[{"name":"Department of Diagnostics and Biological Sciences, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Alex","family":"Fok","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Marmar","family":"Montasser","sequence":"additional","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Algomhoria Street, Mansoura 35516, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3205-345X","authenticated-orcid":false,"given":"Hamdi H.","family":"Hamama","sequence":"additional","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Algomhoria Street, Mansoura 35516, Egypt"},{"name":"Faculty of Dentistry, New-Mansoura University, New-Mansoura 35712, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Salah H.","family":"Mahmoud","sequence":"additional","affiliation":[{"name":"Conservative Dentistry Department, Faculty of Dentistry, Mansoura University, Algomhoria Street, Mansoura 35516, Egypt"},{"name":"Conservative Dentistry Department, Faculty of Dentistry, Horus University, New-Dumyat 34517, Egypt"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9219-951X","authenticated-orcid":false,"given":"Tamer","family":"Abdelrehim","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-0509-0856","authenticated-orcid":false,"given":"Hooi Pin","family":"Chew","sequence":"additional","affiliation":[{"name":"Minnesota Dental Research Center for Biomaterials and Biomechanics, School of Dentistry, University of Minnesota, Minneapolis, MN 55455, USA"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2023,8,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"e55","DOI":"10.1590\/1807-3107bor-2017.vol31.0055","article-title":"Trends in restorative composites research: What is in the future?","volume":"31","author":"Maas","year":"2017","journal-title":"Braz. 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