{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,2,5]],"date-time":"2026-02-05T21:52:54Z","timestamp":1770328374809,"version":"3.49.0"},"reference-count":38,"publisher":"MDPI AG","issue":"18","license":[{"start":{"date-parts":[[2023,9,10]],"date-time":"2023-09-10T00:00:00Z","timestamp":1694304000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006769","name":"Russian Science Foundation","doi-asserted-by":"publisher","award":["22-23-00566"],"award-info":[{"award-number":["22-23-00566"]}],"id":[{"id":"10.13039\/501100006769","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The viscosity values of CO2\u2013dimethylphormamide, chloroform, methanol, isopropanol, ethyl acetate, acetone, and dimethyl sulfoxide mixtures were measured at a pressure of 150 bar and a temperature of 313 K. The correlation of the mean size of levofloxacin hydrochloride and malonic acid particles precipitated using the SAS method with the viscosity of the used CO2\u2013solvent mixtures is shown. The high viscosity of the mixtures leads to slower mixing of the solution and the antisolvent. Therefore, crystallization occurs at large fractions of the solvent, and as a consequence at a lower supersaturation. This causes the formation of larger particles when using more viscous solvents in SAS.<\/jats:p>","DOI":"10.3390\/ma16186151","type":"journal-article","created":{"date-parts":[[2023,9,11]],"date-time":"2023-09-11T09:11:18Z","timestamp":1694423478000},"page":"6151","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":4,"title":["Viscosity Measurement of CO2\u2013Solvent Mixtures for the Study of the Morphology and Size of Crystalline Particles Obtained Using Supercritical Antisolvent Precipitation"],"prefix":"10.3390","volume":"16","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-5442-5675","authenticated-orcid":false,"given":"Anton M.","family":"Vorobei","sequence":"first","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 117901 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-7151-678X","authenticated-orcid":false,"given":"Mikhail O.","family":"Kostenko","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 117901 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Olga O.","family":"Parenago","sequence":"additional","affiliation":[{"name":"Kurnakov Institute of General and Inorganic Chemistry, Russian Academy of Sciences, 117901 Moscow, Russia"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2023,9,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/S0896-8446(98)00129-6","article-title":"Supercritical antisolvent precipitation of micro-and nano-particles","volume":"15","author":"Reverchon","year":"1999","journal-title":"J. Supercrit. Fluids"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"29","DOI":"10.1016\/j.supflu.2017.11.025","article-title":"Investigation of crystallization mechanisms for polymorphic and habit control from the Supercritical AntiSolvent process","volume":"141","author":"Clercq","year":"2018","journal-title":"J. Supercrit. Fluids"},{"key":"ref_3","doi-asserted-by":"crossref","unstructured":"Franco, P., and De Marco, I. (2020). Supercritical antisolvent process for pharmaceutical applications: A review. Processes, 8.","DOI":"10.3390\/pr8080938"},{"key":"ref_4","doi-asserted-by":"crossref","unstructured":"Liu, G., Li, J., and Deng, S. (2021). Applications of Supercritical Anti-Solvent Process in Preparation of Solid Multicomponent Systems. Pharmaceutics, 13.","DOI":"10.3390\/pharmaceutics13040475"},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"1416","DOI":"10.1134\/S1990793122080152","article-title":"Micronization of Levofloxacin Hydrochloride by the Supercritical Antisolvent Precipitation Method from Single-Phase and Two-Phase CO2\u2013Acetone Mixtures","volume":"16","author":"Vorobei","year":"2022","journal-title":"Russ. J. Phys. Chem. B"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"119","DOI":"10.1016\/j.supflu.2016.03.003","article-title":"The facile synthesis of Ni\u2013Cu catalysts stabilized in SiO2 framework via a supercritical antisolvent approach","volume":"112","author":"Nesterov","year":"2016","journal-title":"J. Supercrit. Fluids"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"110","DOI":"10.1016\/j.supflu.2019.03.014","article-title":"Mesoporous aerogel-like Al-Si oxides obtained via supercritical antisolvent precipitation of alumina and silica sols","volume":"149","author":"Nesterov","year":"2019","journal-title":"J. Supercrit. Fluids"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"2998","DOI":"10.1016\/j.ijhydene.2022.10.068","article-title":"Partial oxidation of methane to syngas over SmCoO3-derived catalysts: The effect of the supercritical fluid assisted modification of the perovskite precursor","volume":"48","author":"Gavrikov","year":"2022","journal-title":"Int. J. Hydrogen Energy"},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"18446","DOI":"10.1039\/D2DT03026H","article-title":"Supercritical fluid-assisted modification combined with the resynthesis of SmCoO3 as an effective tool to enhance the long-term performance of SmCoO3-derived catalysts for the dry reforming of methane to syngas","volume":"51","author":"Gavrikov","year":"2022","journal-title":"Dalton Trans."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"479","DOI":"10.1016\/j.jcou.2019.07.032","article-title":"Supercritical antisolvent particle precipitation and fractionation of rosemary (Rosmarinus officinalis L.) extracts","volume":"34","author":"Quintana","year":"2019","journal-title":"J. CO2 Util."},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"128","DOI":"10.1016\/j.foodres.2018.08.027","article-title":"Supercritical anti-solvent fractionation for improving antioxidant and anti-inflammatory activities of an Achillea millefolium L. extract","volume":"115","author":"Villalva","year":"2019","journal-title":"Food Res. Int."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"2257","DOI":"10.1016\/j.apt.2020.03.022","article-title":"Investigation of precipitation selectivity and particle size concentration dependences in supercritical antisolvent method via online supercritical fluid chromatography","volume":"31","author":"Pokrovskiy","year":"2020","journal-title":"Adv. Powder Technol."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"407","DOI":"10.1134\/S0036024421030237","article-title":"Using supercritical fluid technologies to prepare micro-and nanoparticles","volume":"95","author":"Vorobei","year":"2021","journal-title":"Russ. J. Phys. Chem."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"358","DOI":"10.1016\/j.cej.2011.02.064","article-title":"Mechanisms controlling supercritical antisolvent precipitate morphology","volume":"169","author":"Reverchon","year":"2011","journal-title":"Chem. Eng. J."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"446","DOI":"10.1016\/j.cej.2009.10.052","article-title":"Interactions of phase equilibria, jet fluid dynamics and mass transfer during supercritical antisolvent micronization","volume":"156","author":"Reverchon","year":"2010","journal-title":"Chem. Eng. J."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"71","DOI":"10.1016\/j.cej.2012.06.129","article-title":"Interactions of phase equilibria, jet fluid dynamics and mass transfer during supercritical antisolvent micronization: The influence of solvents","volume":"203","author":"Knauer","year":"2012","journal-title":"Chem. Eng. J."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"2421","DOI":"10.1016\/S0009-2509(00)00443-7","article-title":"Particle formation by mixing with supercritical antisolvent at high Reynolds numbers","volume":"56","author":"Shekunov","year":"2001","journal-title":"Chem. Eng. Sci."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"9224","DOI":"10.1021\/ie801940p","article-title":"On the selection of limiting hydrodynamic conditions for the supercritical antisolvent (SAS) process","volume":"48","author":"Tenorio","year":"2009","journal-title":"Ind. Eng. Chem. Res."},{"key":"ref_19","doi-asserted-by":"crossref","first-page":"203","DOI":"10.1016\/j.supflu.2004.02.009","article-title":"Numerical modeling of jet hydrodynamics, mass transfer, and crystallization kinetics in the supercritical antisolvent (SAS) process","volume":"32","author":"Cocero","year":"2004","journal-title":"J. Supercrit. Fluids"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"6863","DOI":"10.1021\/acs.cgd.0c00920","article-title":"Prediction of crystal\u2013solvent interactions in a supercritical medium: A possible way to control crystal habit at high supersaturations with molecular modeling","volume":"20","author":"Clercq","year":"2020","journal-title":"Cryst. Growth Des."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"70","DOI":"10.1016\/j.supflu.2008.06.002","article-title":"Spherical microparticles production by supercritical antisolvent precipitation: Interpretation of results","volume":"47","author":"Reverchon","year":"2008","journal-title":"J. Supercrit. Fluids"},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"230","DOI":"10.1016\/j.supflu.2013.07.015","article-title":"Manipulating the size, the morphology and the polymorphism of acetaminophen using supercritical antisolvent (SAS) precipitation","volume":"82","author":"Rossmann","year":"2013","journal-title":"J. Supercrit. Fluids"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"350","DOI":"10.1016\/j.supflu.2011.11.023","article-title":"Solute solubility as criterion for the appearance of amorphous particle precipitation or crystallization in the supercritical antisolvent (SAS) process","volume":"66","author":"Rossmann","year":"2012","journal-title":"J. Supercrit. Fluids"},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"6222","DOI":"10.1021\/acs.cgd.6b00697","article-title":"Polymorphism in pharmaceutical drugs by supercritical CO2 processing: Clarifying the role of the antisolvent effect and atomization enhancement","volume":"16","author":"Rodrigues","year":"2016","journal-title":"Cryst. Growth Des."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"34","DOI":"10.1016\/j.jcrysgro.2011.06.059","article-title":"Drug recrystallization using supercritical anti-solvent (SAS) process with impinging jets: Effect of process parameters","volume":"342","author":"Careno","year":"2012","journal-title":"J. Cryst. Growth"},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"1943","DOI":"10.1021\/cg2016758","article-title":"Crystallization of caffeine by supercritical antisolvent (SAS) process: Analysis of process parameters and control of polymorphism","volume":"12","author":"Cassel","year":"2012","journal-title":"Cryst. Growth Des."},{"key":"ref_27","unstructured":"Brittain, H.G. (2016). Polymorphism in Pharmaceutical Solids, CRC Press."},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"7019","DOI":"10.1039\/C5CE00992H","article-title":"Thermodynamic characteristics of cocrystal formation and melting points for rational design of pharmaceutical two-component systems","volume":"17","author":"Perlovich","year":"2015","journal-title":"CrystEngComm"},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"1242","DOI":"10.1134\/S1990793122070181","article-title":"Micronization of Adipic Acid via Supercritical Antisolvent Precipitation","volume":"16","author":"Zuev","year":"2022","journal-title":"Russ. J. Phys. Chem. B"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"995","DOI":"10.1080\/10826076.2011.565540","article-title":"Viscosity estimation in binary and ternary supercritical fluid mixtures containing carbon dioxide using a supercritical fluid chromatograph","volume":"34","author":"Fields","year":"2011","journal-title":"J. Liq. Chromatogr. Relat. Technol."},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"35","DOI":"10.1016\/S0021-9673(99)00482-3","article-title":"Validity of Darcy\u2019s law at low flow-rates in liquid chromatography","volume":"849","author":"Farkas","year":"1999","journal-title":"J. Chromatogr. A"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"277","DOI":"10.1016\/j.chroma.2014.07.088","article-title":"Occurrence of turbulent flow conditions in supercritical fluid chromatography","volume":"1361","author":"Choikhet","year":"2014","journal-title":"J. Chromatogr. A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"126","DOI":"10.1016\/j.fluid.2018.10.007","article-title":"High-pressure fluid-phase equilibria: Trends, recent developments, and systems investigated (2009\u20132012)","volume":"484","author":"Peper","year":"2019","journal-title":"Fluid Phase Equilibria"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fluid.2010.09.017","article-title":"High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2005\u20132008)","volume":"300","author":"Fonseca","year":"2011","journal-title":"Fluid Phase Equilibria"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"1","DOI":"10.1016\/j.fluid.2009.08.008","article-title":"High-pressure fluid-phase equilibria: Experimental methods and systems investigated (2000\u20132004)","volume":"288","author":"Dohrn","year":"2010","journal-title":"Fluid Phase Equilibria"},{"key":"ref_36","unstructured":"Lemon, E.W., McLinden, M.O., Friend, D.G., Linstrom, P.J., and Mallard, W.G. (2017). NIST Chemistry Webbook, National Institute of Standarts and Technology. NIST Standart Reference Database No. 69."},{"key":"ref_37","first-page":"1107","article-title":"Russ. J. Preparation of Polyurethane\u2013Carbon Nanotube Composites via Suspension Supercritical Antisolvent Precipitation","volume":"15","author":"Zuev","year":"2021","journal-title":"Phys. Chem. B"},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"1240","DOI":"10.1134\/S1990793118080146","article-title":"Micronization of salbutamol sulfate by supercritical antisolvent precipitation: The effect of process parameters on the size and morphology of particles","volume":"12","author":"Vorobei","year":"2018","journal-title":"Russ. J. Phys. Chem. B"}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/18\/6151\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T20:48:13Z","timestamp":1760129293000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/16\/18\/6151"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2023,9,10]]},"references-count":38,"journal-issue":{"issue":"18","published-online":{"date-parts":[[2023,9]]}},"alternative-id":["ma16186151"],"URL":"https:\/\/doi.org\/10.3390\/ma16186151","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2023,9,10]]}}}