{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,27]],"date-time":"2026-08-27T22:39:19Z","timestamp":1787870359836,"version":"build-2784847793"},"reference-count":63,"publisher":"MDPI AG","issue":"6","license":[{"start":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T00:00:00Z","timestamp":1710115200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Ningbo Youth Science and Technology Innovation Leading Talent Project","award":["2023QL014"],"award-info":[{"award-number":["2023QL014"]}]},{"name":"Ningbo Youth Science and Technology Innovation Leading Talent Project","award":["2023H022"],"award-info":[{"award-number":["2023H022"]}]},{"name":"Ningbo Youth Science and Technology Innovation Leading Talent Project","award":["51574175"],"award-info":[{"award-number":["51574175"]}]},{"name":"Ningbo Youth Science and Technology Innovation Leading Talent Project","award":["51474153"],"award-info":[{"award-number":["51474153"]}]},{"name":"Ningbo International R&amp;D Collaboration Project","award":["2023QL014"],"award-info":[{"award-number":["2023QL014"]}]},{"name":"Ningbo International R&amp;D Collaboration Project","award":["2023H022"],"award-info":[{"award-number":["2023H022"]}]},{"name":"Ningbo International R&amp;D Collaboration Project","award":["51574175"],"award-info":[{"award-number":["51574175"]}]},{"name":"Ningbo International R&amp;D Collaboration Project","award":["51474153"],"award-info":[{"award-number":["51474153"]}]},{"name":"National Nature Science Foundation of China","award":["2023QL014"],"award-info":[{"award-number":["2023QL014"]}]},{"name":"National Nature Science Foundation of China","award":["2023H022"],"award-info":[{"award-number":["2023H022"]}]},{"name":"National Nature Science Foundation of China","award":["51574175"],"award-info":[{"award-number":["51574175"]}]},{"name":"National Nature Science Foundation of China","award":["51474153"],"award-info":[{"award-number":["51474153"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The effect of extrusion on the microstructure, mechanical property, corrosion behavior, and in vitro biocompatibility of as-cast Mg-1.5Zn-1.2Y-0.1Sr (wt.%) alloy was investigated via tensile tests, electrochemical methods, immersion tests, methylthiazolyl diphenyltetrazolium bromide (MTT), and analytical techniques. Results showed that the as-cast and as-extruded Mg-1.5Zn-1.2Y-0.1Sr alloys comprised an \u03b1-Mg matrix and Mg3Y2Zn3 phase (W-phase). In the as-cast alloy, the W-phase was mainly distributed at the grain boundaries, with a small amount of W-phase in the grains. After hot extrusion, the W-phase was broken down into small particles that were dispersed in the alloy, and the grains were refined considerably. The as-extruded alloy exhibited appropriate mechanical properties that were attributed to refinement strengthening, dispersion strengthening, dislocation strengthening, and precipitation strengthening. The as-cast and as-extruded alloys exhibited galvanic corrosion between the W-phase and \u03b1-Mg matrix as the main corrosion mechanism. The coarse W-phase directly caused the poor corrosion resistance of the as-cast alloy. The as-extruded alloy obtained via hydrogen evolution and mass loss had corrosion rates of less than 0.5 mm\/year. MTT, high-content screening (HCS) analysis, and cell adhesion tests revealed that the as-extruded alloy can improve L929 cell viability and has great potential in the field of biomedical biodegradable implant materials.<\/jats:p>","DOI":"10.3390\/ma17061297","type":"journal-article","created":{"date-parts":[[2024,3,11]],"date-time":"2024-03-11T11:05:10Z","timestamp":1710155110000},"page":"1297","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":8,"title":["Effect of Extrusion on Mechanical Property, Corrosion Behavior, and In Vitro Biocompatibility of the As-Cast Mg-Zn-Y-Sr Alloy"],"prefix":"10.3390","volume":"17","author":[{"given":"Tao","family":"Huang","sequence":"first","affiliation":[{"name":"Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8397-0587","authenticated-orcid":false,"given":"Lijing","family":"Yang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Chunxiang","family":"Xu","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Taiyuan University of Technology, No. 79 Yingze West Street, Taiyuan 030024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Cheng","family":"Xu","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-8324-9762","authenticated-orcid":false,"given":"Qingke","family":"Zhang","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Jinshan","family":"Zhang","sequence":"additional","affiliation":[{"name":"College of Materials Science and Engineering, Taiyuan University of Technology, No. 79 Yingze West Street, Taiyuan 030024, China"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Zhenlun","family":"Song","sequence":"additional","affiliation":[{"name":"Key Laboratory of Marine Materials and Related Technologies, Zhejiang Key Laboratory of Marine Materials and Protective Technologies, Ningbo Institute of Materials Technology and Engineering, Chinese Academy of Sciences, Ningbo 315201, China"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,3,11]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"627","DOI":"10.1016\/j.jma.2021.09.005","article-title":"A comprehensive review on biocompatible Mg-based alloys as temporary orthopaedic implants: Current status, challenges, and future prospects","volume":"10","author":"Bairagi","year":"2022","journal-title":"J. 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