{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T15:11:48Z","timestamp":1760109108900,"version":"build-2065373602"},"reference-count":84,"publisher":"MDPI AG","issue":"8","license":[{"start":{"date-parts":[[2024,4,16]],"date-time":"2024-04-16T00:00:00Z","timestamp":1713225600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"German Federal Ministry of Education and Research","award":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"],"award-info":[{"award-number":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"]}]},{"name":"German Research Foundation (DFG)","award":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"],"award-info":[{"award-number":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"]}]},{"name":"European Union and the state of Mecklenburg-West Pomerania (Germany)","award":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"],"award-info":[{"award-number":["03XP0279D","INST 2268\/17-1 FUGG","GHS-15-0016","GHS-16-0002"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Aseptic implant loosening after a total joint replacement is partially influenced by material-specific factors when cobalt\u2013chromium alloys are used, including osteolysis induced by wear and corrosion products and stress shielding. Here, we aim to characterize a hybrid material consisting of alumina-toughened zirconia (ATZ) ceramics and additively manufactured Ti-35Nb-6Ta (TiNbTa) alloys, which are joined by a glass solder. The structure of the joint, the static and fatigue shear strength, the influence of accelerated aging, and the cytotoxicity with human osteoblasts are characterized. Furthermore, the biomechanical properties of the functional demonstrators of a femoral component for total knee replacements are evaluated. The TiNbTa-ATZ specimens showed a homogenous joint with statistically distributed micro-pores and a slight accumulation of Al-rich compounds at the glass solder\u2013TiNbTa interface. Shear strengths of 26.4 \u00b1 4.2 MPa and 38.2 \u00b1 14.4 MPa were achieved for the TiNbTa-ATZ and Ti-ATZ specimens, respectively, and they were not significantly affected by the titanium material used, nor by accelerated aging (p = 0.07). All of the specimens survived 107 cycles of shear loading to 10 MPa. Furthermore, the TiNbTa-ATZ did not impair the proliferation and metabolic activity of the human osteoblasts. Functional demonstrators made of TiNbTa-ATZ provided a maximum bearable extension\u2013flexion moment of 40.7 \u00b1 2.2 Nm. The biomechanical and biological properties of TiNbTa-ATZ demonstrate potential applications for endoprosthetic implants.<\/jats:p>","DOI":"10.3390\/ma17081838","type":"journal-article","created":{"date-parts":[[2024,4,17]],"date-time":"2024-04-17T07:54:36Z","timestamp":1713340476000},"page":"1838","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":1,"title":["Multifunctional Hybrid Material for Endoprosthetic Implants Based on Alumina-Toughened Zirconia Ceramics and Additively Manufactured TiNbTa Alloys"],"prefix":"10.3390","volume":"17","author":[{"given":"Jan-Oliver","family":"Sass","sequence":"first","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0009-0007-2422-8340","authenticated-orcid":false,"given":"Paul","family":"Henke","sequence":"additional","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Aurica","family":"Mitrovic","sequence":"additional","affiliation":[{"name":"ZM Praezisionsdentaltechnik GmbH, Breite Str. 16, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9029-7535","authenticated-orcid":false,"given":"Markus","family":"Weinmann","sequence":"additional","affiliation":[{"name":"TANIOBIS GmbH, Im Schleeke 78-91, D-38642 Goslar, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1244-6360","authenticated-orcid":false,"given":"Daniel","family":"Kluess","sequence":"additional","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"},{"name":"INNOPROFF GmbH, Joachim-Jungius-Stra\u00dfe 9, D-18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-1993-4252","authenticated-orcid":false,"given":"Jan","family":"Johannsen","sequence":"additional","affiliation":[{"name":"Fraunhofer Research Institution for Additive Manufacturing Technologies IAPT, Am Schleusengraben 14, D-21029 Hamburg, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Marie-Luise","family":"Sellin","sequence":"additional","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Ulrich","family":"Lembke","sequence":"additional","affiliation":[{"name":"DOT GmbH, Charles-Darwin-Ring 1A, D-18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Daniel","family":"Reimer","sequence":"additional","affiliation":[{"name":"FMZ GmbH, Charles-Darwin-Ring 3A, D-18059 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Cornelia","family":"Lork","sequence":"additional","affiliation":[{"name":"ZM Praezisionsdentaltechnik GmbH, Breite Str. 16, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Anika","family":"Jonitz-Heincke","sequence":"additional","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Rainer","family":"Bader","sequence":"additional","affiliation":[{"name":"Research Laboratory for Biomechanics and Implant Technology, Department of Orthopaedics, Rostock University Medical Center, Doberaner Stra\u00dfe 142, D-18057 Rostock, Germany"}],"role":[{"role":"author","vocabulary":"crossref"}]}],"member":"1968","published-online":{"date-parts":[[2024,4,16]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"182","DOI":"10.1080\/17453674.2020.1853340","article-title":"Variation and trends in reasons for knee replacement revision: A multi-registry study of revision burden","volume":"92","author":"Lewis","year":"2021","journal-title":"Acta Orthop."},{"key":"ref_2","doi-asserted-by":"crossref","unstructured":"Goodman, S.B., and Gallo, J. 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