{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,5,29]],"date-time":"2026-05-29T16:33:21Z","timestamp":1780072401083,"version":"3.54.0"},"reference-count":49,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,1]],"date-time":"2024-06-01T00:00:00Z","timestamp":1717200000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006041","name":"Nottingham Trent University and Innovate UK","doi-asserted-by":"publisher","award":["106563"],"award-info":[{"award-number":["106563"]}],"id":[{"id":"10.13039\/501100006041","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The COVID-19 pandemic has underscored the critical need for effective air filtration systems in healthcare environments to mitigate the spread of viral and bacterial pathogens. This study explores the utilization of copper nanoparticle-coated materials for air filtration, offering both antiviral and antimicrobial properties. Highly uniform spherical copper oxide nanoparticles (~10 nm) were synthesized via a spinning disc reactor and subsequently functionalized with carboxylated ligands to ensure colloidal stability in aqueous solutions. The functionalized copper oxide nanoparticles were applied as antipathogenic coatings on extruded polyethylene and melt-blown polypropylene fibers to assess their efficacy in air filtration applications. Notably, Type IIR medical facemasks incorporating the copper nanoparticle-coated polyethylene fibers demonstrated a &gt;90% reduction in influenza virus and SARS-CoV-2 within 2 h of exposure. Similarly, heating, ventilation, and air conditioning (HVAC) filtration pre- (polyester) and post (polypropylene)-filtration media were functionalised with the copper nanoparticles and exhibited a 99% reduction in various viral and bacterial strains, including SARS-CoV-2, Pseudomonas aeruginosa, Acinetobacter baumannii, Salmonella enterica, and Escherichia coli. In both cases, this mitigates not only the immediate threat from these pathogens but also the risk of biofouling and secondary risk factors. The assessment of leaching properties confirmed that the copper nanoparticle coatings remained intact on the polymeric fiber surfaces without releasing nanoparticles into the solution or airflow. These findings highlight the potential of nanoparticle-coated materials in developing biocompatible and environmentally friendly air filtration systems for healthcare settings, crucial in combating current and future pandemic threats.<\/jats:p>","DOI":"10.3390\/ma17112664","type":"journal-article","created":{"date-parts":[[2024,6,3]],"date-time":"2024-06-03T05:58:00Z","timestamp":1717394280000},"page":"2664","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Antipathogenic Applications of Copper Nanoparticles in Air Filtration Systems"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0003-0391-3721","authenticated-orcid":false,"given":"Subbareddy","family":"Mekapothula","sequence":"first","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0009-0005-2855-7614","authenticated-orcid":false,"given":"Elvina","family":"Chrysanthou","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"James","family":"Hall","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Phani Durga","family":"Nekkalapudi","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-8551-4307","authenticated-orcid":false,"given":"Samantha","family":"McLean","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4167-1332","authenticated-orcid":false,"given":"Gareth W. V.","family":"Cave","sequence":"additional","affiliation":[{"name":"School of Science and Technology, Nottingham Trent University, Clifton Lane, Nottingham NG11 8NS, UK"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,1]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"101090","DOI":"10.1016\/j.nmni.2023.101090","article-title":"Evaluation of the Bacterial Contamination of Face Masks Worn by Personnel in a Center of COVID 19 Hospitalized Patients: A Cross-Sectional Study","volume":"52","author":"Yousefimashouf","year":"2023","journal-title":"New Microbes New Infect."},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"9891","DOI":"10.1021\/acs.est.1c07923","article-title":"Global Meta-Analysis of Airborne Bacterial Communities and Associations with Anthropogenic Activities","volume":"56","author":"Jiang","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"914","DOI":"10.1016\/S2213-2600(20)30323-4","article-title":"Particle Sizes of Infectious Aerosols: Implications for Infection Control","volume":"8","author":"Fennelly","year":"2020","journal-title":"Lancet Respir. Med."},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"3608","DOI":"10.1021\/acsbiomaterials.0c00348","article-title":"Antiviral and Antibacterial Nanostructured Surfaces with Excellent Mechanical Properties for Hospital Applications","volume":"6","author":"Hasan","year":"2020","journal-title":"ACS Biomater. Sci. Eng."},{"key":"ref_5","doi-asserted-by":"crossref","first-page":"13857","DOI":"10.1021\/acsnano.1c06071","article-title":"Fabrics Attached with Highly Efficient Aggregation-Induced Emission Photosensitizer: Toward Self-Antiviral Personal Protective Equipment","volume":"15","author":"Li","year":"2021","journal-title":"ACS Nano"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"10526","DOI":"10.1021\/acsomega.1c04919","article-title":"Impeding the Medical Protective Clothing Contamination by a Spray Coating of Trifunctional Polymers","volume":"7","author":"Keum","year":"2022","journal-title":"ACS Omega"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"12313","DOI":"10.1021\/acsnano.0c05537","article-title":"Sustainable Personal Protective Clothing for Healthcare Applications: A Review","volume":"14","author":"Karim","year":"2020","journal-title":"ACS Nano"},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"531","DOI":"10.1021\/acsapm.0c01151","article-title":"Polymer Materials for Respiratory Protection: Processing, End Use, and Testing Methods","volume":"3","author":"Armentano","year":"2021","journal-title":"ACS Appl. Polym. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"7035","DOI":"10.1021\/acsnano.3c02099","article-title":"An Intelligent Wearable Filtration System for Health Management","volume":"17","author":"Shi","year":"2023","journal-title":"ACS Nano"},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"53241","DOI":"10.1021\/acsami.2c17791","article-title":"Sterilizable and Reusable UV-Resistant Graphene\u2013Polyurethane Elastomer Composites","volume":"14","author":"Kuo","year":"2022","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_11","doi-asserted-by":"crossref","first-page":"7760","DOI":"10.1021\/acs.est.0c02178","article-title":"COVID-19 Pandemic Repercussions on the Use and Management of Plastics","volume":"54","author":"Prata","year":"2020","journal-title":"Environ. Sci. Technol."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"651","DOI":"10.1021\/acs.estlett.1c00422","article-title":"Single-Use Face Masks as a Potential Source of Synthetic Antioxidants to the Environment","volume":"8","author":"Liu","year":"2021","journal-title":"Environ. Sci. Technol. Lett."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"2100030","DOI":"10.1002\/gch2.202100030","article-title":"Exploring Reusability of Disposable Face Masks: Effects of Disinfection Methods on Filtration Efficiency, Breathability, and Fluid Resistance","volume":"5","author":"Teo","year":"2021","journal-title":"Glob. Chall."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"144956","DOI":"10.1016\/j.scitotenv.2021.144956","article-title":"Air Filtration as a Tool for the Reduction of Viral Aerosols","volume":"772","author":"Zacharias","year":"2021","journal-title":"Sci. Total Environ."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"4295","DOI":"10.1021\/acs.est.2c00885","article-title":"Photosensitized Electrospun Nanofibrous Filters for Capturing and Killing Airborne Coronaviruses under Visible Light Irradiation","volume":"56","author":"Shen","year":"2022","journal-title":"Environ. Sci. Technol."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"7755","DOI":"10.1021\/acsnano.1c11647","article-title":"How to Make Personal Protective Equipment Spontaneously and Continuously Antimicrobial (Incorporating Oxidase-like Catalysts)","volume":"16","author":"Jin","year":"2022","journal-title":"ACS Nano"},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"878","DOI":"10.1016\/j.jhazmat.2013.06.003","article-title":"Mechanistic Antimicrobial Approach of Extracellularly Synthesized Silver Nanoparticles against Gram Positive and Gram Negative Bacteria","volume":"260","author":"Tamboli","year":"2013","journal-title":"J. Hazard. Mater."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"12849","DOI":"10.1021\/acsanm.3c01471","article-title":"Copper-Nanoparticle-Coated Melt-Blown Facemask Filter with Antibacterial and SARS-CoV-2 Antiviral Ability","volume":"6","author":"Sadrhaghighi","year":"2023","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_19","doi-asserted-by":"crossref","unstructured":"Ammendolia, M.G., and De Berardis, B. (2022). Nanoparticle Impact on the Bacterial Adaptation: Focus on Nano-Titania. Nanomaterials, 12.","DOI":"10.3390\/nano12203616"},{"key":"ref_20","doi-asserted-by":"crossref","first-page":"496","DOI":"10.1016\/j.jcis.2021.12.139","article-title":"Facile Nanostructured Zinc Oxide Coating Technique for Antibacterial and Antifouling Air Filters with Low Pressure Drop","volume":"612","author":"Kim","year":"2022","journal-title":"J. Colloid Interface Sci."},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"3657","DOI":"10.1080\/09593330.2019.1617355","article-title":"Antibacterial Behaviour of Surface Modified Composite Polyamide Nanofiltration (NF) Membrane by Immobilizing Ag-Doped TiO2 Nanoparticles","volume":"41","author":"Habib","year":"2019","journal-title":"Environ. Technol."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"106960","DOI":"10.1016\/j.jece.2021.106960","article-title":"Fabrication of CuO Nanoparticles Immobilized Nanofiltration Composite Membrane for Dye\/Salt Fractionation: Performance and Antibiofouling","volume":"10","author":"Waheed","year":"2022","journal-title":"J. Environ. Chem. Eng."},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"12876","DOI":"10.1021\/acsanm.2c02736","article-title":"Copper-Nanoparticle-Coated Fabrics for Rapid and Sustained Antibacterial Activity Applications","volume":"5","author":"Ku","year":"2022","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"631","DOI":"10.1002\/smll.201301174","article-title":"Synthesis and Biomedical Applications of Copper Sulfide Nanoparticles: From Sensors to Theranostics","volume":"10","author":"Goel","year":"2013","journal-title":"Small"},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"68169","DOI":"10.1039\/C5RA08110F","article-title":"Folic Acid Modified Copper Oxide Nanoparticles for Targeted Delivery in In Vitro and In Vivo Systems","volume":"5","author":"Laha","year":"2015","journal-title":"RSC Adv."},{"key":"ref_26","doi-asserted-by":"crossref","first-page":"12","DOI":"10.1016\/j.jpcs.2018.04.015","article-title":"Nonenzymatic Glucose Sensor with High Performance Electrodeposited Nickel\/Copper\/Carbon Nanotubes Nanocomposite Electrode","volume":"120","author":"Ammara","year":"2018","journal-title":"J. Phys. Chem. Solids"},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"34723","DOI":"10.1021\/acsami.0c11425","article-title":"A Surface Coating That Rapidly Inactivates SARS-CoV-2","volume":"12","author":"Behzadinasab","year":"2020","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"352","DOI":"10.1021\/acsanm.0c02713","article-title":"Copper Nanoparticle\u2013Graphene Composite-Based Transparent Surface Coating with Antiviral Activity against Influenza Virus","volume":"4","author":"Jana","year":"2020","journal-title":"ACS Appl. Nano Mater."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"5919","DOI":"10.1021\/acsami.0c19465","article-title":"Cupric Oxide Coating That Rapidly Reduces Infection by SARS-CoV-2 via Solids","volume":"13","author":"Hosseini","year":"2021","journal-title":"ACS Appl. Mater. Interfaces"},{"key":"ref_30","doi-asserted-by":"crossref","unstructured":"Liu, M., Bauman, L., Nogueira, C.L., Aucoin, M.G., Anderson, W.A., and Zhao, B. (2022). Antimicrobial Polymeric Composites for High-Touch Surfaces in Healthcare Applications. Curr. Opin. Biomed. Eng., 22.","DOI":"10.1016\/j.cobme.2022.100395"},{"key":"ref_31","doi-asserted-by":"crossref","unstructured":"Merkl, P., Long, S., McInerney, G.M., and Sotiriou, G.A. (2021). Antiviral Activity of Silver, Copper Oxide and Zinc Oxide Nanoparticle Coatings against SARS-CoV-2. Nanomaterials, 11.","DOI":"10.3390\/nano11051312"},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"951","DOI":"10.1128\/AEM.06284-11","article-title":"Novel Antiviral Characteristics of Nanosized Copper(I) Iodide Particles Showing Inactivation Activity against 2009 Pandemic H1N1 Influenza Virus","volume":"78","author":"Fujimori","year":"2012","journal-title":"Appl. Environ. Microbiol."},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"119136","DOI":"10.1016\/j.carbpol.2022.119136","article-title":"Functionalization of Cellulosic Hydrogels with Cu2O@CuO Nanospheres: Toward Antifouling Applications","volume":"282","author":"Zhang","year":"2022","journal-title":"Carbohydr. Polym."},{"key":"ref_34","doi-asserted-by":"crossref","unstructured":"Jard\u00f3n-Maximino, N., Cadenas-Pliego, G., \u00c1vila-Orta, C.A., Compar\u00e1n-Padilla, V.E., Uribe, L.E.L., P\u00e9rez-\u00c1lvarez, M., Fern\u00e1ndez, S., and De Jes\u00fas Sosa Santill\u00e1n, G. (2021). Antimicrobial Property of Polypropylene Composites and Functionalized Copper Nanoparticles. Polymers, 13.","DOI":"10.3390\/polym13111694"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"61","DOI":"10.1016\/j.matchemphys.2007.09.002","article-title":"The Antimicrobial Efficacy of Polyamide 6\/Silver-Nano- and Microcomposites","volume":"108","author":"Damm","year":"2008","journal-title":"Mater. Chem. Phys."},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"4792735","DOI":"10.1155\/2018\/4792735","article-title":"Synthesis and Thermomechanical Characterization of Nylon 6\/Cu Nanocomposites Produced by an Ultrasound-Assisted Extrusion Method","volume":"2018","year":"2018","journal-title":"Adv. Mat. Sci. Eng."},{"key":"ref_37","unstructured":"Smith, N., Raston, C.L., Saunders, M., and Woodward, R. (2006). Technical Proceedings of the 2006 NSTI Nanotechnology Conference and Trade Show, Nano Science and Technology Institute."},{"key":"ref_38","unstructured":"Cave, G.W.V., and Mundell, V.J. (2013). Coating Metal Oxide Particles. (EP2825515A2)."},{"key":"ref_39","unstructured":"(2019). Textiles\u2014Determination of Antiviral Activity of Textile Products (Standard No. ISO 18184:2019). Available online: https:\/\/www.iso.org\/standard\/71292.html."},{"key":"ref_40","unstructured":"Massart, R. (1982). Magnetic Fluids and Process For Obtaining Them. (U.S. Patent 4329241)."},{"key":"ref_41","unstructured":"Cave, G.W.V. (2021). Reactor. (U.S. Patent 10926236B2)."},{"key":"ref_42","unstructured":"(2023). Water Quality\u2014Application of Inductively Coupled Plasma Mass Spectrometry (ICP-MS) (Standard No. ISO 17294-2:2023). Available online: https:\/\/www.iso.org\/standard\/82245.html."},{"key":"ref_43","unstructured":"(2019). Medical Face Masks Requirements and Test Methods (Standard No. EN 14683:2019+AC:2019)."},{"key":"ref_44","unstructured":"(2018). Sterilization of Health Care Products\u2014Microbiological methods Part 1: Determination of a Population of Microorganisms on Products (Standard No. EN ISO 11737-1:2018)."},{"key":"ref_45","unstructured":"(2004). Clothing for Protection against Infectious Agents\u2014Medical Face Masks\u2014Test Method for Resistance against Penetration by Synthetic Blood (Fixed Volume, Horizontally Projected) (Standard No. ISO 22609:2004)."},{"key":"ref_46","unstructured":"(2013). Biological Evaluation of Medical Devices\u2014Part 10: Tests for Irritation and Skin Sensitization (Standard No. EN ISO 10993-10:2013)."},{"key":"ref_47","unstructured":"(2009). Biological Evaluation of Medical Devices\u2014Part 5: Tests for In Vitro Cytotoxicity (Standard No. ISO 10993-5:2009)."},{"key":"ref_48","unstructured":"(2021). Textiles\u2014Determination of Antibacterial Activity of Textile Products (Standard No. ISO 20743:2021). Available online: https:\/\/www.iso.org\/standard\/79819.html."},{"key":"ref_49","unstructured":"(2024, April 10). ESCMID\u2014European Society of Clinical Microbiology and Infectious Diseases 2008 Eucast: EUCAST. Available online: https:\/\/www.eucast.org\/."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/11\/2664\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:52:12Z","timestamp":1760107932000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/11\/2664"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,1]]},"references-count":49,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ma17112664"],"URL":"https:\/\/doi.org\/10.3390\/ma17112664","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,1]]}}}