{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,21]],"date-time":"2026-08-21T12:11:20Z","timestamp":1787314280688,"version":"build-2736575974"},"reference-count":45,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,4]],"date-time":"2024-06-04T00:00:00Z","timestamp":1717459200000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100001659","name":"German Research Foundation","doi-asserted-by":"publisher","award":["446067715"],"award-info":[{"award-number":["446067715"]}],"id":[{"id":"10.13039\/501100001659","id-type":"DOI","asserted-by":"publisher"}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>The magnesium alloy ZK60 is a promising candidate as a material for biodegradable implants. One of the most important factors for biodegradable implants is the modification of their corrosion behavior to match the requirements for the healing bone or tissue. The corrosion behavior can be influenced by different factors, among them the grain size, which can be changed by severe plastic deformation processes such as High Pressure Torsion Extrusion (HPTE). This study focuses on the corrosion behavior of samples of pure magnesium and ZK60 before and after HPTE, and the influence of the microstructure on the corrosion activity. The samples are subjected to immersion tests in phosphate buffered saline solution (PBS). The corrosion activity is defined by the emerging hydrogen volume from the corrosion process which is collected and by subsequently observing the resulting sample surfaces. The findings of this study suggest that pure magnesium shows lower corrosion activities than ZK60 and that HPTE processing leads to higher corrosion activities in PBS.<\/jats:p>","DOI":"10.3390\/ma17112726","type":"journal-article","created":{"date-parts":[[2024,6,5]],"date-time":"2024-06-05T08:43:54Z","timestamp":1717577034000},"page":"2726","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Corrosion Activity of Ultrafine-Grained Pure Magnesium and ZK60 Magnesium Alloy in Phosphate Buffered Saline Solution"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0009-0006-1448-5178","authenticated-orcid":false,"given":"Stella","family":"Diederichs","sequence":"first","affiliation":[{"name":"Working Group Materials Testing (AWP), RPTU Kaiserslautern-Landau, Gottlieb-Daimler-Stra\u00dfe, 67663 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-9212-0963","authenticated-orcid":false,"given":"Dayan","family":"Nugmanov","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-6705-1721","authenticated-orcid":false,"given":"Yulia","family":"Ivanisenko","sequence":"additional","affiliation":[{"name":"Institute of Nanotechnology, Karlsruhe Institute of Technology (KIT), Hermann-von-Helmholtz-Platz 1, 76344 Eggenstein-Leopoldshafen, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-7211-1306","authenticated-orcid":false,"given":"Eberhard","family":"Kerscher","sequence":"additional","affiliation":[{"name":"Working Group Materials Testing (AWP), RPTU Kaiserslautern-Landau, Gottlieb-Daimler-Stra\u00dfe, 67663 Kaiserslautern, Germany"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,6,4]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1143","DOI":"10.1007\/s11837-015-1366-z","article-title":"A Review of Stress-Corrosion Cracking and Corrosion Fatigue of Magnesium Alloys for Biodegradable Implant Applications","volume":"67","author":"Jafari","year":"2015","journal-title":"JOM"},{"key":"ref_2","doi-asserted-by":"crossref","first-page":"916","DOI":"10.1016\/j.actbio.2011.10.031","article-title":"Magnesium alloys as body implants: Fracture mechanism under dynamic and static loadings in a physiological environment","volume":"8","author":"Choudhary","year":"2012","journal-title":"Acta Biomater."},{"key":"ref_3","doi-asserted-by":"crossref","first-page":"1912","DOI":"10.1039\/C3TB21746A","article-title":"Effects of alloying elements on the corrosion behavior and biocompatibility of biodegradable magnesium alloys: A review","volume":"2","author":"Ding","year":"2014","journal-title":"J. Mater. Chem. B"},{"key":"ref_4","doi-asserted-by":"crossref","first-page":"2607","DOI":"10.1016\/j.jma.2022.09.007","article-title":"Corrosion behavior of severely plastically deformed Mg and Mg alloys","volume":"10","author":"Bahmani","year":"2022","journal-title":"J. Magnes. Alloy."},{"key":"ref_5","doi-asserted-by":"crossref","unstructured":"Chakraborty Banerjee, P., Al-Saadi, S., Choudhary, L., Harandi, S.E., and Singh, R. (2019). Magnesium Implants: Prospects and Challenges. Materials, 12.","DOI":"10.3390\/ma12010136"},{"key":"ref_6","doi-asserted-by":"crossref","first-page":"1728","DOI":"10.1016\/j.biomaterials.2005.10.003","article-title":"Magnesium and its alloys as orthopedic biomaterials: A review","volume":"27","author":"Staiger","year":"2006","journal-title":"Biomaterials"},{"key":"ref_7","doi-asserted-by":"crossref","first-page":"1763","DOI":"10.1016\/j.actbio.2009.04.041","article-title":"Corrosion behaviour of AZ31 magnesium alloy with different grain sizes in simulated biological fluids","volume":"6","author":"Pereda","year":"2010","journal-title":"Acta Biomater."},{"key":"ref_8","doi-asserted-by":"crossref","first-page":"887","DOI":"10.1038\/nmat2542","article-title":"MgZnCa glasses without clinically observable hydrogen evolution for biodegradable implants","volume":"8","author":"Zberg","year":"2009","journal-title":"Nat. Mater."},{"key":"ref_9","doi-asserted-by":"crossref","first-page":"1766","DOI":"10.1016\/j.corsci.2008.03.003","article-title":"The relation between microstructure and corrosion behavior of AZ80 Mg alloy following different extrusion temperatures","volume":"50","author":"Eliezer","year":"2008","journal-title":"Corros. Sci."},{"key":"ref_10","doi-asserted-by":"crossref","first-page":"362","DOI":"10.1016\/j.corsci.2010.09.044","article-title":"Corrosion behaviour of bulk ultra-fine grained AZ91D magnesium alloy fabricated by equal-channel angular pressing","volume":"53","author":"Song","year":"2011","journal-title":"Corros. Sci."},{"key":"ref_11","first-page":"19","article-title":"Effect of heat treatment on mechanical and biodegradable properties of an extruded ZK60 alloy","volume":"2","author":"Chen","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_12","doi-asserted-by":"crossref","first-page":"962","DOI":"10.1007\/s12613-020-2053-9","article-title":"Developing Mg-Zn surface alloy by friction surface allosying: In vitro degradation studies in simulated body fluids","volume":"27","author":"Badisha","year":"2020","journal-title":"Int. J. Miner. Metall. Mater."},{"key":"ref_13","doi-asserted-by":"crossref","first-page":"242","DOI":"10.1002\/mawe.200900434","article-title":"Influence of grain size on mechanical and corrosion properties of magnesium alloy for medical implants","volume":"40","author":"Kutniy","year":"2009","journal-title":"Mater. Werkst."},{"key":"ref_14","doi-asserted-by":"crossref","first-page":"145","DOI":"10.1016\/j.corsci.2012.01.021","article-title":"Effects of grain size on the corrosion resistance of wrought magnesium alloys containing neodymium","volume":"58","author":"Argade","year":"2012","journal-title":"Corros. Sci."},{"key":"ref_15","doi-asserted-by":"crossref","first-page":"229","DOI":"10.4028\/www.scientific.net\/KEM.384.229","article-title":"Surface Grain Size Effects on the Corrosion of Magnesium","volume":"384","author":"Birbilis","year":"2008","journal-title":"Key Eng. Mater."},{"key":"ref_16","doi-asserted-by":"crossref","first-page":"222","DOI":"10.1016\/j.jallcom.2008.01.084","article-title":"The relation between severe plastic deformation microstructure and corrosion behavior of AZ31 magnesium alloy","volume":"468","author":"Hamu","year":"2009","journal-title":"J. Alloy. Compd."},{"key":"ref_17","doi-asserted-by":"crossref","first-page":"177","DOI":"10.1016\/j.jma.2013.09.003","article-title":"Advances in Mg corrosion and research suggestions","volume":"1","author":"Atrens","year":"2013","journal-title":"J. Magnes. Alloy."},{"key":"ref_18","doi-asserted-by":"crossref","first-page":"3168","DOI":"10.1016\/j.corsci.2008.08.023","article-title":"Influence of pH and chloride ion concentration on the corrosion of Mg alloy ZE41","volume":"50","author":"Zhao","year":"2008","journal-title":"Corros. Sci."},{"key":"ref_19","unstructured":"Stanfield, C. (2017). Principles of Human Physiology, Global Edition, Pearson Education, Limited."},{"key":"ref_20","doi-asserted-by":"crossref","unstructured":"Raut, S.K., Singh, K., Sanghvi, S., Loyo-Celis, V., Varghese, L., Singh, E.R., Gururaja Rao, S., and Singh, H. (2024). Chloride ions in health and disease. Biosci. Rep., 44.","DOI":"10.1042\/BSR20240029"},{"key":"ref_21","doi-asserted-by":"crossref","first-page":"347","DOI":"10.1016\/j.apsusc.2005.01.169","article-title":"Corrosion behaviour of laser-melted magnesium alloys","volume":"247","author":"Abbas","year":"2005","journal-title":"Appl. Surf. Sci."},{"key":"ref_22","doi-asserted-by":"crossref","first-page":"247","DOI":"10.1016\/j.msea.2016.04.008","article-title":"High Pressure Torsion Extrusion as a new severe plastic deformation process","volume":"664","author":"Ivanisenko","year":"2016","journal-title":"Mater. Sci. Eng. A"},{"key":"ref_23","doi-asserted-by":"crossref","first-page":"893","DOI":"10.1016\/j.pmatsci.2008.03.002","article-title":"Using high-pressure torsion for metal processing: Fundamentals and applications","volume":"53","author":"Zhilyaev","year":"2008","journal-title":"Prog. Mater. Sci."},{"key":"ref_24","doi-asserted-by":"crossref","first-page":"1147","DOI":"10.1016\/j.scriptamat.2004.08.018","article-title":"Production of submicrocrystalline structure in large-scale Ti\u20136Al\u20134V billet by warm severe deformation processing","volume":"51","author":"Zherebtsov","year":"2004","journal-title":"Scr. Mater."},{"key":"ref_25","doi-asserted-by":"crossref","first-page":"373","DOI":"10.1016\/j.jmapro.2020.04.052","article-title":"Finite element modeling of Conform-HPTE process for a continuous severe plastic deformation path","volume":"55","author":"Hu","year":"2020","journal-title":"J. Manuf. Process."},{"key":"ref_26","unstructured":"Friedrich, H.E., and Mordike, B.L. (2006). Magnesium Technology: Metallurgy, Design Data, Applications, Springer."},{"key":"ref_27","doi-asserted-by":"crossref","first-page":"84","DOI":"10.1016\/j.ultramic.2016.07.007","article-title":"Challenges in quantitative crystallographic characterization of 3D thin films by ACOM-TEM","volume":"173","author":"Kobler","year":"2017","journal-title":"Ultramicroscopy"},{"key":"ref_28","doi-asserted-by":"crossref","first-page":"589","DOI":"10.1016\/j.corsci.2009.10.018","article-title":"Effect of grain size and twins on corrosion behaviour of AZ31B magnesium alloy","volume":"52","author":"Aung","year":"2010","journal-title":"Corros. Sci."},{"key":"ref_29","doi-asserted-by":"crossref","first-page":"634","DOI":"10.1007\/BF02669156","article-title":"The Mg-Zn-Zr system (magnesium-zinc-zirconium)","volume":"14","author":"Bhan","year":"1993","journal-title":"J. Phase Equilibria"},{"key":"ref_30","doi-asserted-by":"crossref","first-page":"3891","DOI":"10.1007\/s11661-012-1217-2","article-title":"Precipitation and Hardening in Magnesium Alloys","volume":"43","author":"Nie","year":"2012","journal-title":"Metall. Mater. Trans. A"},{"key":"ref_31","doi-asserted-by":"crossref","first-page":"10","DOI":"10.1016\/j.actamat.2015.05.012","article-title":"The interaction of grain refinement and ageing in magnesium\u2013zinc\u2013zirconium (ZK) alloys","volume":"95","author":"Robson","year":"2015","journal-title":"Acta Mater."},{"key":"ref_32","doi-asserted-by":"crossref","first-page":"1087","DOI":"10.1007\/s11661-012-1438-4","article-title":"Ultrafine-Grain Structure Formation in an Al-Mg-Sc Alloy During Warm ECAP","volume":"44","author":"Sitdikov","year":"2013","journal-title":"Metall. Mater. Trans. A"},{"key":"ref_33","doi-asserted-by":"crossref","first-page":"330","DOI":"10.1016\/j.msea.2017.10.008","article-title":"Structure, texture and strength of Mg-5.8Zn-0.65Zr alloy after hot-to-warm multi-step isothermal forging and isothermal rolling to large strains","volume":"709","author":"Markushev","year":"2018","journal-title":"Mater. Sci. Eng. A"},{"key":"ref_34","doi-asserted-by":"crossref","first-page":"81","DOI":"10.1016\/j.msea.2017.12.045","article-title":"Origin of plastic anisotropy in (ultra)-fine-grained Mg\u2013Zn\u2013Zr alloy processed by isothermal multi-step forging and rolling: Experiments and modeling","volume":"713","author":"Nugmanov","year":"2018","journal-title":"Mater. Sci. Eng. A"},{"key":"ref_35","doi-asserted-by":"crossref","first-page":"588","DOI":"10.1016\/S1003-6326(08)60102-8","article-title":"Corrosion behavior of Mg and Mg-Zn alloys in simulated body fluid","volume":"18","author":"Gao","year":"2008","journal-title":"Trans. Nonferrous Met. Soc. China"},{"key":"ref_36","doi-asserted-by":"crossref","first-page":"2623","DOI":"10.1007\/s10856-010-4111-8","article-title":"In vitro degradation behavior and cytocompatibility of Mg-Zn-Zr alloys","volume":"21","author":"Huan","year":"2010","journal-title":"J. Mater. Sci. Mater. Med."},{"key":"ref_37","first-page":"53","article-title":"Biodegradation behavior of magnesium and ZK60 alloy in artificial urine and rat models","volume":"2","author":"Zhang","year":"2017","journal-title":"Bioact. Mater."},{"key":"ref_38","doi-asserted-by":"crossref","first-page":"484","DOI":"10.1016\/j.biomaterials.2008.10.021","article-title":"In vitro corrosion and biocompatibility of binary magnesium alloys","volume":"30","author":"Gu","year":"2009","journal-title":"Biomaterials"},{"key":"ref_39","doi-asserted-by":"crossref","first-page":"291","DOI":"10.1016\/j.jallcom.2015.06.227","article-title":"Influence of zinc on the microstructure, mechanical properties and in vitro corrosion behavior of magnesium\u2013zinc binary alloys","volume":"648","author":"Kannan","year":"2015","journal-title":"J. Alloy. Compd."},{"key":"ref_40","doi-asserted-by":"crossref","first-page":"8427","DOI":"10.1039\/D2RA07829E","article-title":"Recent research advances on corrosion mechanism and protection, and novel coating materials of magnesium alloys: A review","volume":"13","author":"Wei","year":"2023","journal-title":"RSC Adv."},{"key":"ref_41","doi-asserted-by":"crossref","first-page":"36","DOI":"10.1016\/j.elecom.2017.10.001","article-title":"A kinetic model explaining the enhanced rates of hydrogen evolution on anodically polarized magnesium in aqueous environments","volume":"84","author":"Fajardo","year":"2017","journal-title":"Electrochem. Commun."},{"key":"ref_42","doi-asserted-by":"crossref","first-page":"400","DOI":"10.1002\/adem.201400434","article-title":"Review of Recent Developments in the Field of Magnesium Corrosion","volume":"17","author":"Atrens","year":"2015","journal-title":"Adv. Eng. Mater."},{"key":"ref_43","doi-asserted-by":"crossref","first-page":"90","DOI":"10.1016\/j.corsci.2012.04.040","article-title":"Grain size distribution effects on the corrosion behaviour of materials","volume":"62","author":"Gollapudi","year":"2012","journal-title":"Corros. Sci."},{"key":"ref_44","doi-asserted-by":"crossref","first-page":"481","DOI":"10.1016\/j.corsci.2009.10.004","article-title":"Corrosion behavior of equal-channel-angular-pressed pure magnesium in NaCl aqueous solution","volume":"52","author":"Song","year":"2010","journal-title":"Corros. Sci."},{"key":"ref_45","doi-asserted-by":"crossref","first-page":"113","DOI":"10.1016\/j.cirp.2007.05.029","article-title":"Biocompatible Magnesium Alloys as Absorbable Implant Materials\u2014Adjusted Surface and Subsurface Properties by Machining Processes","volume":"56","author":"Denkena","year":"2007","journal-title":"CIRP Ann."}],"container-title":["Materials"],"original-title":[],"language":"en","link":[{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/11\/2726\/pdf","content-type":"unspecified","content-version":"vor","intended-application":"similarity-checking"}],"deposited":{"date-parts":[[2025,10,10]],"date-time":"2025-10-10T14:53:20Z","timestamp":1760108000000},"score":1,"resource":{"primary":{"URL":"https:\/\/www.mdpi.com\/1996-1944\/17\/11\/2726"}},"subtitle":[],"short-title":[],"issued":{"date-parts":[[2024,6,4]]},"references-count":45,"journal-issue":{"issue":"11","published-online":{"date-parts":[[2024,6]]}},"alternative-id":["ma17112726"],"URL":"https:\/\/doi.org\/10.3390\/ma17112726","relation":{},"ISSN":["1996-1944"],"issn-type":[{"value":"1996-1944","type":"electronic"}],"subject":[],"published":{"date-parts":[[2024,6,4]]}}}