{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,4,17]],"date-time":"2026-04-17T16:12:01Z","timestamp":1776442321735,"version":"3.51.2"},"reference-count":63,"publisher":"MDPI AG","issue":"11","license":[{"start":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T00:00:00Z","timestamp":1717632000000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["CNFIS-FDI-2024-F-0484"],"award-info":[{"award-number":["CNFIS-FDI-2024-F-0484"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["23020101"],"award-info":[{"award-number":["23020101"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"DOI":"10.13039\/501100006595","name":"UEFISCDI","doi-asserted-by":"publisher","award":["PN 23.06.02\u2014InteGral"],"award-info":[{"award-number":["PN 23.06.02\u2014InteGral"]}],"id":[{"id":"10.13039\/501100006595","id-type":"DOI","asserted-by":"publisher"}]},{"name":"Ministry of Research, Innovation, and Digitalization (MCID)","award":["CNFIS-FDI-2024-F-0484"],"award-info":[{"award-number":["CNFIS-FDI-2024-F-0484"]}]},{"name":"Ministry of Research, Innovation, and Digitalization (MCID)","award":["23020101"],"award-info":[{"award-number":["23020101"]}]},{"name":"Ministry of Research, Innovation, and Digitalization (MCID)","award":["PN 23.06.02\u2014InteGral"],"award-info":[{"award-number":["PN 23.06.02\u2014InteGral"]}]},{"name":"Ministry of Research, Innovation, and Digitization","award":["CNFIS-FDI-2024-F-0484"],"award-info":[{"award-number":["CNFIS-FDI-2024-F-0484"]}]},{"name":"Ministry of Research, Innovation, and Digitization","award":["23020101"],"award-info":[{"award-number":["23020101"]}]},{"name":"Ministry of Research, Innovation, and Digitization","award":["PN 23.06.02\u2014InteGral"],"award-info":[{"award-number":["PN 23.06.02\u2014InteGral"]}]}],"content-domain":{"domain":["www.mdpi.com"],"crossmark-restriction":true},"short-container-title":["Materials"],"abstract":"<jats:p>Silicon-based quantum dots (SiQDs) represent a special class of nanoparticles due to their low toxicity and easily modifiable surface properties. For this reason, they are used in applications such as bioimaging, fluorescent labeling, drug delivery, protein detection techniques, and tissue engineering despite a serious lack of information on possible in vivo effects. The present study aimed to characterize and evaluate the in vivo toxicity of SiQDs obtained by laser ablation in the lung and spleen of mice. The particles were administered in three different doses (1, 10, and 100 mg QDs\/kg of body weight) by intravenous injection into the caudal vein of Swiss mice. After 1, 6, 24, and 72 h, the animals were euthanized, and the lung and spleen tissues were harvested for the evaluation of antioxidant enzyme activity, lipid peroxidation, protein expression, and epigenetic and morphological changes. The obtained results highlighted a low toxicity in pulmonary and splenic tissues for concentrations up to 10 mg SiQDs\/kg body, demonstrated by biochemical and histopathological analysis. Therefore, our study brings new experimental evidence on the biocompatibility of this type of QD, suggesting the possibility of expanding research on the biomedical applications of SiQDs.<\/jats:p>","DOI":"10.3390\/ma17112778","type":"journal-article","created":{"date-parts":[[2024,6,6]],"date-time":"2024-06-06T12:04:28Z","timestamp":1717675468000},"page":"2778","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["Exploring In Vivo Pulmonary and Splenic Toxicity Profiles of Silicon Quantum Dots in Mice"],"prefix":"10.3390","volume":"17","author":[{"given":"Roxana-Elena","family":"Cristian","sequence":"first","affiliation":[{"name":"Department of Biochemistry and Molecular Biology, Faculty of Biology, University of Bucharest, 91-95 Splaiul Independentei, 050095 Bucharest, Romania"},{"name":"DANUBIUS Department, National Institute of Research and Development for Biological Sciences, Splaiul Independentei 296, 060031 Bucharest, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-5734-0071","authenticated-orcid":false,"given":"Cornel","family":"Balta","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"given":"Hildegard","family":"Herman","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0001-6502-2655","authenticated-orcid":false,"given":"Alina","family":"Ciceu","sequence":"additional","affiliation":[{"name":"\u201cAurel Ardelean\u201d Institute of Life Sciences, Vasile Goldis Western University of Arad, 86 Rebreanu, 310414 Arad, Romania"}],"role":[{"role":"author","vocabulary":"crossref"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9948-6914","authenticated-orcid":false,"given":"Bogdan","family":"Trica","sequence":"additional","affiliation":[{"name":"National Institute for Research & Development in Chemistry and Petrochemistry (INCDCP-ICECHIM), 202 Spl. 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