{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,9,17]],"date-time":"2026-09-17T21:53:17Z","timestamp":1789681997138,"version":"4.0.1"},"reference-count":74,"publisher":"MDPI AG","issue":"14","license":[{"start":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T00:00:00Z","timestamp":1720569600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"Romanian Ministry of Research, Innovation and Digitalization","award":["PC1-PN23080101"],"award-info":[{"award-number":["PC1-PN23080101"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Infections related to orthopedic\/stomatology surgery are widely recognized as a significant health concern. Therefore, the development of new materials with superior biological properties and good stability could represent a valuable alternative to the classical treatments. In this paper, the fluorine-substituted hydroxyapatite (FHAp) suspension, with the chemical formula Ca10(PO4)6(OH)2\u22122xF2x (where x = 0.05), was prepared using a modified coprecipitation technique. Stability studies were conducted by zeta potential and ultrasound measurements for the first time. The X-ray diffraction (XRD) patterns of FHAp powders displayed a hexagonal structure akin to that of pure hydroxyapatite (HAp). The XPS general spectrum revealed peaks corresponding to the constituent elements of fluorine-substituted hydroxyapatite such as calcium, phosphorus, oxygen, and fluorine. The purity of the obtained FHAp samples was confirmed by energy-dispersive X-ray spectroscopy (EDS) studies. The FHAp morphology was evaluated by scanning electron microscopy (SEM) measurements. Fourier-transform infrared spectroscopy (FTIR) studies were performed in order to study the vibrational properties of the FHAp samples. The FHAp suspensions were tested for antibacterial activity against reference strains such as Staphylococcus aureus 25923 ATCC, Escherichia coli ATCC 25922, and Candida albicans ATCC 10231. Additionally, the biocompatibility of the FHAp suspensions was assessed using human fetal osteoblastic cells (hFOB 1.19 cell line). The results of our biological tests suggest that FHAp suspensions are promising candidates for the future development of new biocompatible and antimicrobial agents for use in the biomedical field.<\/jats:p>","DOI":"10.3390\/ma17143404","type":"journal-article","created":{"date-parts":[[2024,7,10]],"date-time":"2024-07-10T13:34:38Z","timestamp":1720618478000},"page":"3404","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":20,"title":["Physico-Chemical and Biological Features of Fluorine-Substituted Hydroxyapatite Suspensions"],"prefix":"10.3390","volume":"17","author":[{"ORCID":"https:\/\/orcid.org\/0000-0002-6044-4311","authenticated-orcid":false,"given":"Carmen Steluta","family":"Ciobanu","sequence":"first","affiliation":[{"name":"National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Daniela","family":"Predoi","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-9139-5903","authenticated-orcid":false,"given":"Simona Liliana","family":"Iconaru","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mihai Valentin","family":"Predoi","sequence":"additional","affiliation":[{"name":"Department of Mechanics, University Politehnica of Bucharest, BN 002, 313 Splaiul Independentei, Sector 6, 060042 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-1040-7213","authenticated-orcid":false,"given":"Krzysztof","family":"Rokosz","sequence":"additional","affiliation":[{"name":"Faculty of Electronics and Computer Science, Koszalin University of Technology, Sniadeckich 2, PL 75-453 Koszalin, Poland"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Steinar","family":"Raaen","sequence":"additional","affiliation":[{"name":"Department of Physics, Norwegian University of Science and Technology (NTNU), Realfagbygget E3-124 H\u00f8gskoleringen 5, NO 7491 Trondheim, Norway"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Catalin Constantin","family":"Negrila","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Nicolas","family":"Buton","sequence":"additional","affiliation":[{"name":"HORIBA Jobin Yvon S.A.S., 6\u201318, Rue du Canal, 91165 Longjumeau CEDEX, France"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Liliana","family":"Ghegoiu","sequence":"additional","affiliation":[{"name":"National Institute of Materials Physics, Atomistilor Street, No. 405A, 077125 Magurele, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Monica Luminita","family":"Badea","sequence":"additional","affiliation":[{"name":"Faculty of Horticulture, University of Agronomic Sciences and Veterinary Medicine, 59 Marasti Blvd., 011464 Bucharest, Romania"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,10]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1487","DOI":"10.1111\/j.1151-2916.1991.tb07132.x","article-title":"Bioceramics: From concept to clinic","volume":"74","author":"Hench","year":"1991","journal-title":"J. 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