{"status":"ok","message-type":"work","message-version":"1.0.0","message":{"indexed":{"date-parts":[[2026,8,18]],"date-time":"2026-08-18T04:54:07Z","timestamp":1787028847367,"version":"build-2736575974"},"reference-count":62,"publisher":"MDPI AG","issue":"15","license":[{"start":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T00:00:00Z","timestamp":1721865600000},"content-version":"vor","delay-in-days":0,"URL":"https:\/\/creativecommons.org\/licenses\/by\/4.0\/"}],"funder":[{"name":"AMED","award":["JP18hk0102055"],"award-info":[{"award-number":["JP18hk0102055"]}]},{"name":"AMED","award":["JP22hk0102087"],"award-info":[{"award-number":["JP22hk0102087"]}]},{"name":"Suzuken Memorial Foundation","award":["JP18hk0102055"],"award-info":[{"award-number":["JP18hk0102055"]}]},{"name":"Suzuken Memorial Foundation","award":["JP22hk0102087"],"award-info":[{"award-number":["JP22hk0102087"]}]}],"content-domain":{"domain":[],"crossmark-restriction":false},"short-container-title":["Materials"],"abstract":"<jats:p>Bioabsorbable materials have a wide range of applications, such as scaffolds for regenerative medicine and cell transplantation therapy and carriers for drug delivery systems. Therefore, although many researchers are conducting their research and development, few of them have been used in clinical practice. In addition, existing bioabsorbable materials cannot bind to the body\u2019s tissues. If bioabsorbable materials with an adhesive ability to biological tissues can be made, they can ensure the mixture remains fixed to the affected area when mixed with artificial bone or other materials. In addition, if the filling material in the bone defect is soft and uncured, resorption is rapid, which is advantageous for bone regeneration. In this paper, the development and process of a new bioabsorbable material \u201cPhosphorylated pullulan\u201d and its capability as a bone replacement material were demonstrated. Phosphorylated pullulan, which was developed based on the tooth adhesion theory, is the only bioabsorbable material able to adhere to bone and teeth. The phosphorylated pullulan and \u03b2-TCP mixture is a non-hardening putty. It is useful as a new resorbable bone replacement material with an adhesive ability for bone defects around implants.<\/jats:p>","DOI":"10.3390\/ma17153671","type":"journal-article","created":{"date-parts":[[2024,7,25]],"date-time":"2024-07-25T08:40:04Z","timestamp":1721896804000},"page":"3671","update-policy":"https:\/\/doi.org\/10.3390\/mdpi_crossmark_policy","source":"Crossref","is-referenced-by-count":5,"title":["From Tooth Adhesion to Bioadhesion: Development of Bioabsorbable Putty-like Artificial Bone with Adhesive to Bone Based on the New Material \u201cPhosphorylated Pullulan\u201d"],"prefix":"10.3390","volume":"17","author":[{"given":"Ko","family":"Nakanishi","sequence":"first","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Tsukasa","family":"Akasaka","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Hiroshi","family":"Hayashi","sequence":"additional","affiliation":[{"name":"Section for Dental Innovation, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-3483-6012","authenticated-orcid":false,"given":"Kumiko","family":"Yoshihara","sequence":"additional","affiliation":[{"name":"Health and Medical Research Institute, National Institute of Advanced Industrial Science and Technology, 2217-14 Hayashi-Cho, Takamaysu 761-0395, Kagawa, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0003-3204-0245","authenticated-orcid":false,"given":"Teppei","family":"Nakamura","sequence":"additional","affiliation":[{"name":"Department of Applied Veterinary Science, Faculty of Veterinary Medicine, Hokkaido University, Kita 18, Nishi 9, Kita-ku, Sapporo 060-0818, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Mariko","family":"Nakamura","sequence":"additional","affiliation":[{"name":"School of Clinical Psychology, Kyushu University of Medical Science, 1714-1 Yoshinocho, Nobeoka 882-8508, Miyazaki, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"ORCID":"https:\/\/orcid.org\/0000-0002-4097-5836","authenticated-orcid":false,"given":"Bart Van","family":"Meerbeek","sequence":"additional","affiliation":[{"name":"KU Leuven, Department of Oral Health Sciences, BIOMAT & UZ Leuven, Dentistry, 3000 Leuven, Belgium"}],"role":[{"vocabulary":"crossref","role":"author"}]},{"given":"Yasuhiro","family":"Yoshida","sequence":"additional","affiliation":[{"name":"Department of Biomaterials and Bioengineering, Faculty of Dental Medicine, Hokkaido University, Kita 13, Nishi 7, Kita-ku, Sapporo 060-8586, Hokkaido, Japan"}],"role":[{"vocabulary":"crossref","role":"author"}]}],"member":"1968","published-online":{"date-parts":[[2024,7,25]]},"reference":[{"key":"ref_1","doi-asserted-by":"crossref","first-page":"1138","DOI":"10.1111\/clr.13660","article-title":"Peri-implant defect grafting with autogenous bone or bone graft material in immediate implant placement in molar extraction sites\u20141- to 3-year results of a prospective randomized study","volume":"31","author":"Noelken","year":"2020","journal-title":"Clin. 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